Lymph node disorder

This phase 3 trial is testing whether atorvastatin, a common cholesterol drug, is safe and can reduce inflammation in children with Kawasaki disease who also have coronary artery abnormalities. The study will enroll 9 children and give them different doses of atorvastatin for 6 w…

This early-phase study tests a new radioactive drug called NRT6008, given alongside standard chemotherapy, for people with advanced pancreatic cancer that cannot be removed by surgery or has spread to nearby lymph nodes. The trial will enroll 58 adults to find the safest dose and…

This study tests whether a 2-month combination of four drugs can cure drug-susceptible tuberculosis in children under 10 as safely and effectively as the standard 4- to 6-month regimen. Researchers will enroll 860 children, including those with HIV, to compare the shorter treatme…

This study tests a bone marrow transplant from a family donor for children under 21 with severe non-cancer blood disorders like sickle cell disease, bone marrow failure, or immune problems. The goal is to see if the transplant can replace the diseased cells with healthy donor cel…

This study tests a new type of radiation therapy for men with prostate cancer that has spread to lymph nodes in the abdomen or pelvis. The treatment uses daily CT scans to adjust the radiation beam precisely to the tumor and nearby at-risk areas. The goal is to control the cancer…

This study tests a way to give radiation therapy for cancer that has spread to lymph nodes in the belly or pelvis. Normally, patients need 5 sessions of a precise type of radiation called SBRT. This study uses daily scans to adjust the radiation beam, which may allow some patient…

This trial is testing a device that uses electrical pulses to destroy cancer cells in neck lymph nodes of people with thyroid cancer that has come back after surgery. About 85 participants will receive one or two treatments under ultrasound guidance. The main goal is to see how m…

This study compares two surgical approaches for papillary thyroid cancer that has spread to lymph nodes in the neck: robotic surgery through the armpit versus traditional open surgery. The goal is to see if the robotic method offers similar cancer control and survival rates while…

This pilot study tests the blood thinner Rivaroxaban in 10 Chinese children who developed giant coronary artery aneurysms after Kawasaki disease. The goal is to see if a specially adjusted dose can prevent new blood clots in the heart arteries while keeping bleeding risks low. Ch…

This study tests if a safe green dye (indocyanine green) can help surgeons find lymph nodes that might contain cancer during a mastectomy, without needing a separate cut under the arm. About 90 women with early-stage breast cancer will receive the dye and a standard radioactive t…

This study compares three methods for reading CT and MRI scans of lymph nodes to see which best detects cancer. The new method, LN-RADS, may find small metastases that current guidelines miss. Researchers will enroll 1,000 people with known or suspected cancer who need a lymph no…

This study is testing a computer tool called Kawasaki MATCH that helps doctors decide if a child with fever has Kawasaki Disease. The tool uses patient age, lab results, and symptoms to give a risk score. Researchers want to see if using this tool leads to faster treatment. About…

This study is developing an artificial intelligence (AI) model to detect whether cancer has spread to lymph nodes by analyzing digital images of tissue slides. Researchers will compare the AI's accuracy to that of pathologists using slides from 10,000 cancer patients. The goal is…

This study tests a new type of ultrasound called super-resolution ultrasound (SRUS) to see if it can better tell the difference between benign (non-cancerous) and malignant (cancerous) swollen lymph nodes. About 779 adults with abnormal lymph nodes will receive an injection of ul…

This study aims to learn more about how diseases related to blood clots, the immune system, and blood vessels start and change over time. Researchers will enroll up to 1,000 people aged 5 and older, including those with these conditions, their healthy relatives, and healthy volun…

This study asks 3000 teens and young adults (ages 15-39) with cancer, along with their caregivers, to answer survey questions about body image, fertility, and financial stress. The goal is to create better tools to measure quality of life for future patients. Participants include…

This study aims to help Dutch hospitals switch from using a radioactive tracer to a green dye called indocyanine green (ICG) to find the first lymph node that breast cancer may spread to. The dye is given during surgery, avoids radiation, and requires no extra hospital visits. Re…

This study looks for better ways to detect lung inflammation and infections early in people who have received a stem cell transplant from a donor. About 40 participants aged 5 to 70 will get regular lung scans, breathing tests, blood draws, and a procedure where a tube collects f…

This study is auditing a surgical technique called Targeted Sentinel Node Biopsy (TSNB) for breast cancer patients who have a small number of cancer cells in their lymph nodes. The goal is to see if this less invasive procedure can accurately identify cancer spread while causing …

This study is observing how doctors manage complicated infections of the ears, nose, throat, and neck in both children and adults. Researchers will track standard treatments like surgery or medication to understand current practices. No new treatments are being tested; the goal i…

This study is testing whether wearable activity trackers like Fitbits and iPhones can help predict when cancer patients undergoing radiation therapy might need emergency care or hospitalization. Researchers will collect step counts and other health data from 260 participants to b…

This study is collecting blood and other samples from 5,000 children and young adults (under 21) who are already taking certain medications as part of their regular care. The goal is to understand how these drugs move through and affect children's bodies, so doctors can prescribe…

This study is testing a tool called B-COMPASS that uses a 22-question survey to predict whether people will follow their prescribed treatments. Researchers will enroll 3100 adults with cardiovascular, endocrine, immune, nerve, cancer, or rare diseases across Europe. The goal is t…

This study tests a standardized technique for finding lymph nodes in lung tissue removed during surgery. Researchers want to see if this method finds more nodes and improves cancer staging. About 160 adults with lung cancer who are having a lobectomy will take part. The goal is t…

This study looks at whether regular groin ultrasound scans can safely replace surgery to check for cancer spread in women with early-stage vulvar cancer. About 30 women will be randomly assigned to either have groin surgery or get ultrasound checks every 2 months for a year. The …

This study is creating a large registry of 800 people receiving biologic medications for immune conditions like autoimmune diseases and primary immune deficiencies. Researchers will collect blood samples and health data to better understand how these treatments work and who respo…

This study looks at whether a blood test can find tiny bits of tumor DNA left after breast cancer surgery. It includes 100 women with early-stage breast cancer that spread to 1-3 lymph nodes. The goal is to see if this test can help predict which patients are more likely to have …

This study is creating an artificial intelligence (AI) model that uses MRI scans and tissue samples to predict whether high-risk prostate cancer has spread to nearby lymph nodes. The goal is to help doctors make better treatment decisions without needing extra invasive tests. Abo…

This study looks at two scoring tools (Kobayashi and Kawanet) to see if they can identify children with Kawasaki disease who are likely to resist standard IVIG treatment. About 10-20% of children don't respond to IVIG and face a higher risk of heart problems. Researchers will enr…