Lower respiratory tract disorder
MONDO:0000270A disease involving the lower respiratory tract.
Also known as: disease of lower respiratory tract, disease or disorder of lower respiratory tract, disorder of lower respiratory tract, lower respiratory tract disease, lower respiratory tract disease or disorder
7952 clinical trials for this condition and its sub-types, 18 tagged with Lower respiratory tract disorder itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Lower respiratory tract disorder
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Lung disorder 251 trials · 7,091 incl. sub-types
33 sub-types
- Lung neoplasm 1,371 trials · 4,046 incl. sub-types Sub-types →
- Obstructive lung disease 36 trials · 1,074 incl. sub-types Sub-types →
- Respiratory failure 280 trials · 790 incl. sub-types Sub-types →
- Interstitial lung disease 257 trials · 729 incl. sub-types Sub-types →
- Pneumonitis 15 trials · 646 incl. sub-types Sub-types →
- Bronchiolitis 51 trials · 104 incl. sub-types Sub-types →
- Acute lung injury 90 trials
- Fungal lung infectious disease 6 trials · 57 incl. sub-types Sub-types →
- Pulmonary non-tuberculous mycobacterial infection 48 trials
- Aspiration pneumonia 33 trials
- Acute chest syndrome 30 trials
- Middle lobe syndrome 29 trials
- Pulmonary systemic sclerosis 27 trials
- Pulmonary coin lesion 24 trials
- Pulmonary alveolar proteinosis 9 trials · 13 incl. sub-types Sub-types →
- Pulmonary artery disease 12 trials
- Rheumatoid arthritis-associated interstitial lung disease 12 trials
- Occupational lung disease 4 trials · 8 incl. sub-types Sub-types →
- Restrictive pulmonary disease 8 trials
- Neonatal aspiration syndrome 1 trial · 6 incl. sub-types Sub-types →
- Lung abscess 3 trials
- Pneumonic plague 3 trials
- Hantavirus pulmonary syndrome 2 trials
- Pulmonary immaturity 2 trials
- Wilson-Mikity syndrome 0 trials
- Dystrophic pulmonary ossification 0 trials
- Pulmonary alveolar microlithiasis 0 trials
- Pulmonary embolism and infarction 0 trials
- Pulmonary plasma cell granuloma 0 trials
- Pulmonary venoocclusive disease 0 trials Sub-types →
- Shrinking lung syndrome 0 trials
- Silo filler disease 0 trials
- Vanishing lung syndrome 0 trials
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Tracheal disorder 6 trials · 1,091 incl. sub-types
8 sub-types
- Chronic obstructive pulmonary disease 937 trials · 1,054 incl. sub-types Sub-types →
- Tracheal stenosis 20 trials
- Tracheitis 2 trials · 7 incl. sub-types Sub-types →
- Congenital tracheomalacia 6 trials
- Trachea neoplasm 2 trials · 5 incl. sub-types Sub-types →
- Isolated tracheo-esophageal fistula 2 trials
- Laryngotracheoesophageal cleft 1 trial Sub-types →
- Tracheal calcification 0 trials
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Bronchial disorder 19 trials · 1,012 incl. sub-types
6 sub-types
- Asthma 725 trials · 820 incl. sub-types Sub-types →
- Bronchiectasis 119 trials · 120 incl. sub-types Sub-types →
- Bronchitis 24 trials · 50 incl. sub-types Sub-types →
- Bronchial neoplasm 20 trials · 38 incl. sub-types Sub-types →
- Non-syndromic bridging bronchus 0 trials
- Non-syndromic congenital bronchial atresia 0 trials
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Pleural disorder 15 trials · 177 incl. sub-types
5 sub-types
- Pleural neoplasm 5 trials · 97 incl. sub-types Sub-types →
- Pneumothorax 35 trials · 45 incl. sub-types Sub-types →
- Pleural empyema 20 trials Sub-types →
- Pleurisy 2 trials · 9 incl. sub-types Sub-types →
- Congenital chylothorax 0 trials
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Tracheobronchitis 5 trials · 55 incl. sub-types
2 sub-types
- Bronchitis 24 trials · 50 incl. sub-types Sub-types →
- Tracheitis 2 trials · 7 incl. sub-types Sub-types →
Most studied deeper sub-types
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Major RSV vaccine trial aims to protect seniors from severe lung infections
Vaccine CompletedThis large phase 3 study tested an experimental RSV vaccine in over 25,000 adults aged 60 and older. The goal was to see if a single shot could prevent lower respiratory tract disease caused by RSV, a common virus that can be dangerous for seniors. Participants received either th…
Phase 3 • Sponsor: Janssen Vaccines & Prevention B.V. • Aim: Vaccine
Last updated Jun 27, 2026 07:57 UTC
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Could a lower oxygen threshold get kids home sooner?
Disease control CompletedThis trial tests whether using a lower oxygen saturation threshold (88%) versus the standard (92%) to decide when to give supplemental oxygen helps children aged 6 weeks to 12 years recover faster from respiratory distress. Participants are randomly assigned to one of two groups,…
Sponsor: Spaarne Gasthuis • Aim: Disease control
Last updated Jul 16, 2026 00:00 UTC
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Could a cold virus drug prevent COPD Flare-Ups?
Disease control CompletedThis study tested whether the drug vapendavir can reduce breathing problems in people with COPD who catch a rhinovirus (common cold). Fifty-two adults with COPD were given either vapendavir or a placebo after being exposed to the virus. The main goal was to see if vapendavir lowe…
Phase 2 • Sponsor: Altesa Biosciences, Inc. • Aim: Disease control
Last updated Jun 27, 2026 07:53 UTC
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Breakthrough shot shields babies from deadly RSV
Prevention CompletedThis study tested a single dose of nirsevimab, a lab-made antibody, in 800 healthy preterm and term infants in China to see if it could prevent serious lung infections caused by RSV. The goal was to reduce doctor visits and hospital stays during the RSV season. Results showed the…
Phase 3 • Sponsor: AstraZeneca • Aim: Prevention
Last updated Jun 27, 2026 12:02 UTC
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Parent power: Family-Centered care may speed recovery for sick infants
Symptom relief CompletedThis study tested whether a family-centered care approach—where parents are trained and actively involved—improves vital signs and shortens recovery time in infants (28 days to 2 years) with lower respiratory tract infections who need high-flow nasal oxygen. Sixty infants partici…
Sponsor: Ankara Etlik City Hospital • Aim: Symptom relief
Last updated Jun 26, 2026 19:14 UTC
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Smart testing slashes antibiotic overuse in ER lung cases
Knowledge-focused CompletedThis study tested a new way to decide if patients with lower respiratory tract infections need antibiotics. Instead of relying on standard methods, doctors used a step-by-step approach: a clinical score, a lung ultrasound, and a blood test for procalcitonin. The goal was to reduc…
Sponsor: Dr Boillat-Blanco Noemie • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC