Hypothyroidism

This Phase 3 trial is testing an experimental tablet made from desiccated porcine thyroid extract, called North Star, in people with primary hypothyroidism. The study aims to see if this treatment can bring thyroid-stimulating hormone (TSH) levels into the normal range. Participa…

This study tests whether adding a physical activity program to standard care can improve health in older women who have three conditions: underactive thyroid (hypothyroidism), glaucoma (high pressure in the eyes), and fatty liver. Researchers will measure changes in eye pressure,…

This study offers expanded access to an experimental stem cell treatment for up to 7 adults with Multiple System Atrophy (MSA), a rare and serious brain disorder. Participants will receive 12 intravenous infusions and 6 spinal injections of donor stem cells over 44 weeks. The goa…

This study tests whether adding a second thyroid hormone (liothyronine) to the standard levothyroxine treatment can improve cholesterol levels and quality of life in people with hypothyroidism. About 90 adults with hypothyroidism will be randomly assigned to receive either standa…

This study looks at three forms of levothyroxine (a thyroid hormone medicine) given to babies diagnosed with congenital hypothyroidism. Researchers will compare a new oral solution to standard liquid drops and tablets, checking how well they control hormone levels and affect deve…

This study looks at whether hypothyroidism caused by immune checkpoint inhibitors (a type of cancer immunotherapy) can go away after stopping the immunotherapy. 107 adult cancer patients who developed hypothyroidism during treatment and are now off immunotherapy will gradually re…

This study looks at whether older adults (65+) with hypothyroidism can safely take their thyroid medication (levothyroxine) with more flexible dosing. Researchers want to see if this affects quality of life, tiredness, and thinking skills. The trial involves 228 participants and …

This study tests a program to help doctors safely reduce or stop thyroid hormone medication in adults aged 65 and older who are getting too much or don't need it. The goal is to prevent harm from overtreatment while keeping thyroid levels healthy. About 900 participants will take…

This study looks at whether treating children with a mild form of underactive thyroid (subclinical hypothyroidism) using a medication called levothyroxine can improve how well their hearts pump blood. The researchers will measure heart function in 40 children aged 4 to 15 before …

This study tests whether giving levothyroxine (a thyroid hormone) to people with mild underactive thyroid before and after heart bypass surgery can lower the risk of serious heart problems like heart attack, stroke, or irregular heartbeat. About 338 adults will be randomly assign…

This study looks at whether giving levothyroxine (a thyroid hormone medication) to women with subclinical hypothyroidism (a mild underactive thyroid) can improve their chances of having a baby through IVF. About 900 women aged 18-45 will be included, and researchers will compare …

This large study compares Armour Thyroid, a natural thyroid extract, to standard synthetic T4 (levothyroxine) in adults with primary hypothyroidism. About 2,800 participants who are stable on synthetic T4 will be randomly assigned to continue their current treatment or switch to …

This study tests whether giving a thyroid hormone supplement (levothyroxine) to dialysis patients with mild hypothyroidism can improve their quality of life and heart health. About 336 adults on hemodialysis will receive either the hormone or a placebo for up to two years. The go…

This early-phase trial tests a drug called Aleeto, a nerve repair protein made from stem cells, in 20 people with Multiple System Atrophy (MSA), a rare brain disease. The study checks if Aleeto is safe and might help with symptoms. Participants receive the drug via injection into…

This study tests a computer model called OptiThyDose that helps doctors find the best dose of thyroid medication for children with congenital hypothyroidism or Graves' disease. The model uses past lab results to keep thyroid hormone levels in a healthy range. About 150 children w…

This study tests whether adding levothyroxine (a thyroid hormone) to the standard fertility drug letrozole helps women with PCOS and mild underactive thyroid ovulate and get pregnant. Two hundred women will be randomly assigned to receive either letrozole alone or letrozole plus …

This study is testing a new blood test to help doctors diagnose Parkinson's disease and similar brain disorders more accurately and earlier. Researchers will use a technique called RT-QuIC to detect misfolded proteins in blood samples from 458 participants, including healthy peop…

This study tests whether a physical activity program can improve hormone levels and body measures in 40 women with PCOS who also have fatty pancreas and mild thyroid problems. Participants will follow an exercise plan, and researchers will track changes in sex hormones, blood sug…

This study tests whether adding an Ayurvedic diet to standard thyroid medication can reduce lingering symptoms like fatigue and weight gain in people with hypothyroidism. About 88 adults with primary hypothyroidism who are already on stable levothyroxine treatment will follow a p…

This study tests a decision support tool that uses blood samples from the first two weeks after thyroid surgery to predict the best levothyroxine dose. Normally, dose adjustments take months of trial and error. The trial will enroll 240 patients and compare the tool's guidance to…

This study compares two 12-week resistance training programs—nonlinear and linear periodization—to see which better improves quality of life in women with hypothyroidism. 75 women aged 35-45 with controlled hypothyroidism will participate. The goal is to find an exercise approach…

This study follows people with SPLIS, a rare inherited metabolic condition, to map its natural history—how the disease unfolds over time. Researchers will track growth, organ function, quality of life, and survival in about 28 participants. The goal is to understand the full rang…

This study tests whether a smart wristband that records nighttime heart rate and rhythm can tell if the dose of thyroid medication (levothyroxine) is too high or too low after total thyroid removal. Forty adults will wear the wristband for the first month after surgery, and the d…

This study from the National Human Genome Research Institute aims to better understand Congenital Disorders of Glycosylation (CDG), a group of rare genetic conditions that affect how the body attaches sugars to proteins and fats. Researchers will examine up to 200 participants, i…

This study follows up to 2,500 people with thyroid problems like hyperthyroidism, hypothyroidism, or Graves' disease. Researchers will track how these conditions develop over time using standard medical tests and genetic samples. The goal is to better understand the natural histo…

This study aims to see how common fatty liver disease (MASLD) is in people with underactive thyroid (hypothyroidism) who do not have diabetes. Researchers will use blood tests, ultrasound, and a special liver scan (FibroScan) to check 200 adults. The goal is to understand if thyr…

This study is looking at the genes of 350 children born with permanent congenital hypothyroidism, even though their thyroid gland is in the right place. Researchers will use advanced genetic sequencing to find DNA changes that might explain the condition. The goal is to better un…

This study looks at how physical activity, tiredness, social support, and mental well-being are related in women with primary hypothyroidism (an underactive thyroid). Researchers will track 96 women from clinics in Asturias, Spain, using questionnaires. The goal is to understand …

This study follows 35 people with severe obesity who are having mini-gastric bypass surgery. Researchers want to see how the surgery changes body composition and improves related health issues like type 2 diabetes, sleep apnea, high blood pressure, and fatty liver disease. The go…

This study looks at how babies aged 6 to 18 months with congenital hypothyroidism (a thyroid condition present at birth) develop their motor skills, sensory processing, and neurological health. Researchers will assess 40 infants who have been on treatment since birth, using stand…

This study is checking if thyroid problems (too much or too little thyroid hormone) change results of liver function tests. Researchers will measure bilirubin levels in 100 adults aged 20-60, comparing those with thyroid disease to healthy volunteers. The goal is to better unders…

This study looks at whether measuring a different thyroid hormone (fT3) or the ratio of two hormones (fT3/fT4) can give a clearer picture of thyroid health in people taking levothyroxine. It includes 500 adults with various types of hypothyroidism who are on a stable dose of the …