Hypothyroidism
MONDO:0005420Abnormally low levels of thyroid hormone.
Also known as: hypothyroidism, underactive thyroid, hypothyroid
54 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsSub-types
Broader categories
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Can a simple education program boost vitamin d in hypothyroid patients?
Disease control CompletedThis study tests whether a pharmacist-led education program can help women with hypothyroidism and low vitamin D levels improve their vitamin D levels and medication habits. Sixty women will be split into two groups: one receives standard care, the other gets counseling, brochure…
Phase: NA • Sponsor: Karadeniz Technical University • Aim: Disease control
Last updated Aug 18, 2026 03:00 UTC
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Can a higher starting dose of thyroid hormone speed up recovery in newborns?
Disease control CompletedThis trial tests whether a higher starting dose of levothyroxine, a thyroid hormone replacement, helps newborns with congenital hypothyroidism reach normal thyroid function faster than a moderate dose. About 100 full-term infants diagnosed at birth are randomly assigned to one of…
Phase: PHASE4 • Sponsor: Menoufia University • Aim: Disease control
Last updated Aug 12, 2026 00:00 UTC
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Foot flex could tame cholesterol and blood sugar
Disease control CompletedThis study tests whether a simple foot exercise called the soleus pushup can improve cholesterol, blood sugar, and hormone levels in people with thyroid problems, high blood pressure, or diabetes. Participants will perform the exercise, and researchers will measure changes in blo…
Phase: NA • Sponsor: King Abdullah University Hospital • Aim: Disease control
Last updated Jul 09, 2026 00:00 UTC
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Video tool boosts thyroid pill adherence in new study
Disease control CompletedThis study tested a patient decision aid—a short video—to help adults with hypothyroidism who were not getting enough thyroid hormone. The video explains the condition, the role of thyroxine, and factors that affect absorption. Researchers randomly assigned 236 patients to watch …
Phase: NA • Sponsor: SingHealth Polyclinics • Aim: Disease control
Last updated Jun 27, 2026 12:10 UTC
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New thyroid drug shows promise in phase 2 trial
Disease control CompletedThis study tested a new hormone replacement therapy called North Star against the standard drug levothyroxine in 303 adults with hypothyroidism. The goal was to find the right dose of North Star to keep thyroid hormone levels normal. Participants were already stable on levothyrox…
Phase: PHASE2 • Sponsor: Neuvosyn Laboratories, LLC • Aim: Disease control
Last updated Jun 27, 2026 09:06 UTC
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Thyroid treatment may not fully restore metabolic health, study finds
Knowledge-focused CompletedThis study looked at 88 women newly diagnosed with primary hypothyroidism (underactive thyroid) to see if taking levothyroxine to normalize thyroid hormones also improves metabolic health. Researchers measured special proteins called adipokines, which are linked to fat tissue and…
Sponsor: Başakşehir Çam & Sakura City Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:01 UTC
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New 3D scan could improve thyroid testing
Knowledge-focused CompletedThis study tested whether a newer 3D imaging method (SPECT/CT) is as accurate as the standard 2D method for measuring how much the thyroid gland takes up a radioactive tracer. 27 people with underactive or overactive thyroids were scanned with both methods. The goal was to see if…
Sponsor: Centre Hospitalier Princesse Grace • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:39 UTC
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Thyroid thickness may predict breathing tube challenges in hypothyroidism patients
Knowledge-focused CompletedThis study looked at 220 adults with treated hypothyroidism to see if a thinner thyroid gland makes it harder to place a breathing tube during general anesthesia. Researchers measured thyroid thickness with ultrasound before surgery and recorded intubation difficulty. The goal is…
Sponsor: Konya City Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:06 UTC
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Breast cancer radiation may harm thyroid, study warns
Knowledge-focused CompletedThis study looked at 729 breast cancer patients who had surgery followed by radiation. Researchers checked their thyroid function before and after treatment to see how many developed an underactive thyroid (hypothyroidism). The goal was to find out which patients are at higher ri…
Sponsor: Cancer Institute and Hospital, Chinese Academy of Medical Sciences • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:10 UTC
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Gene hunt aims to unlock mysteries of thyroid disorder in newborns
Knowledge-focused CompletedThis study looked at 558 people with congenital hypothyroidism, a rare thyroid condition found in newborns. Researchers examined their genes, medical images, and health records to find links between genetic changes and the type or severity of the disease. The goal is to improve e…
Phase: NA • Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 26, 2026 14:58 UTC