Hearing loss disorder

This trial tests a gene therapy called SENS-501 for children aged 6 to 31 months who are severely or profoundly deaf due to mutations in the otoferlin gene. The therapy is injected directly into one inner ear to deliver a working copy of the gene. The goal is to restore natural h…

This study tests a new type of cochlear implant that is completely hidden under the skin, with no external processor. It is designed for adults with severe hearing loss who do not get enough benefit from hearing aids. The implant picks up sound through a microphone under the skin…

This study tests the Sentio bone-anchored hearing system in 50 children aged 3 to 11 with hearing loss or single-sided deafness. The device is already approved for older kids and adults. Researchers want to see if it safely improves hearing compared to no aid. The trial is happen…

This study follows 629 older adults for 3 years to see if using hearing aids and getting hearing rehab can slow down memory loss and lower the risk of dementia. Participants were already in an earlier trial and now continue with hearing care or a delayed treatment. The goal is to…

This early-stage trial tests whether a substance called VSF1.01, made from stem cell secretions, can safely reduce trauma to the inner ear during cochlear implant surgery. Eleven adults with severe hearing loss will receive the treatment directly into the cochlea before the impla…

This study follows 100 people with vestibular schwannoma (a non-cancerous ear tumor) who previously received a gene therapy called AAVAnc80-antiVEGF. Researchers will monitor for late side effects and measure tumor size changes over time using MRI scans. The goal is to understand…

This study tests a drug called SPI-1005 in 200 adults with Meniere's disease, a condition that causes hearing loss, ringing in the ears, and dizziness. Participants will take the drug twice a day for 6 or 12 months to see if it is safe and tolerable. The goal is to find a treatme…

This study tests a new totally implantable cochlear implant system (TICI G2) that has a microphone under the skin, so you can hear without any external devices. Researchers will enroll 18 adults with sensorineural hearing loss to see how well the internal microphone works over ti…

This study follows 30 people who previously received a gene therapy (AAVAnc80-hOTOF) for hearing loss caused by otoferlin gene mutations. Researchers will monitor safety over the long term, checking for late side effects, and measure hearing improvements using brain response test…

This early-phase study is testing whether stem cell therapies and experimental drugs can help repair inner ear damage in people with hearing loss or tinnitus. Researchers will monitor 120 adults over time using hearing tests and symptom surveys. The goal is to see if these regene…

This study compares cochlear implants to hearing aids in 80 children aged 4 to 14 with hearing loss in one ear. Researchers measure how well kids understand speech and hear in noise before and after getting an implant. The goal is to see if the implant provides better hearing tha…

This study tests whether a personalized, data-driven hearing rehabilitation program can improve hearing, thinking, and quality of life in older adults with mild to moderate hearing loss. Two hundred first-time hearing aid users will be randomly assigned to either the new personal…

This study tests a single injection of a new drug called AC102 into the ear, comparing it to standard steroid pills for sudden hearing loss. About 210 adults with hearing loss in one ear will take part. The goal is to see if the injection improves hearing better than steroids, wi…

This study was designed to see if a small device placed in the inner ear during acoustic neuroma surgery can keep the cochlea from filling with scar tissue. If successful, patients who lose hearing from the surgery could still get a cochlear implant later. The study was withdrawn…

This study tests an advanced ultrasound otoscope, a device that uses sound waves to look inside the ear and detect fluid behind the eardrum. Researchers will compare its readings to the surgeon's findings during ear tube surgery in 300 children up to 12 years old. The goal is to …

This study was designed to test whether an oral drug called SPI-1005 could prevent hearing loss and ringing in the ears caused by platinum-based chemotherapy. It was planned for adults with advanced lung or head and neck cancer. The study was withdrawn before enrolling any partic…

This study tests whether sodium thiosulfate can prevent hearing loss in children and young adults (ages 1 month to 39 years) who are receiving cisplatin chemotherapy for relapsed or hard-to-treat liver tumors and other embryonal cancers. Some participants also get vorinostat. The…

This study looks at how different types of follow-up support affect new hearing aid users. Participants can choose an online program, a clinic visit, or no follow-up. The goal is to see if the online option helps reduce the emotional and social impact of hearing loss as much as a…

This study looks at whether cochlear implants are safe and effective for adults with severe hearing loss in both ears who currently don't meet standard implant criteria. Fifty participants will receive an implant and be followed for 6 months to measure improvements in word recogn…

This study tests whether motivational interviewing, a counseling style that encourages behavior change, can help new hearing aid users wear their devices more often and feel better about their hearing. Researchers will enroll 180 adults who are new to hearing aids and compare tho…

This study tests a mobile app called iPREPARED that helps patients and their caregivers prepare for a hospital stay. The app provides videos and tips to prevent or reduce delirium, a sudden confused state common in older adults. Researchers want to see if the app is easy to use a…

This study tests whether an 8-week auditory-cognitive training program can improve speech recognition and cognitive function in older adults (60+) who have had a cochlear implant for 3 months to 3 years. Participants will do computer-based listening and thinking exercises at home…

This study tests a hearing care program for older Korean Americans (age 60+) who have hearing loss but do not use hearing aids. The program includes a low-cost sound amplifier and communication training, delivered in the community. Researchers will compare participants who get th…

This study tests experimental sound coding strategies that may improve hearing for adult cochlear implant users. About 120 participants will compare the new strategies to their current settings, focusing on understanding speech in noisy environments. The goal is to find ways to m…

This study tests a new cochlear implant that slowly releases a drug called dexamethasone to reduce swelling and tissue damage after surgery. The goal is to see if this helps the implant work better and improve hearing in adults with severe hearing loss. About 56 adults will recei…

This study tests an 8-week exercise program designed for deaf adults aged 60 and older. The classes are taught in American Sign Language and meet twice a week. Researchers will measure balance, leg strength, walking speed, and confidence to see if the program helps reduce fall ri…

This study is testing whether hearing aids alone or hearing aids with a tinnitus masker can improve hearing and reduce tinnitus symptoms in adults with hearing loss and tinnitus. One hundred participants will wear hearing aids for 6 months, with the masker turned on after 3 month…

This study tests whether using special communication technology (AAC) alongside speech therapy helps children who are deaf or hard of hearing develop language faster. Half of the 154 children will use AAC tools, while the other half continue their usual therapy. Researchers will …

This study looks at whether traditional exercises like Tai Chi and Baduanjin can help people with hearing loss feel better physically and mentally. About 90 adults with severe hearing loss will be split into three groups: one doing Tai Chi, one doing Baduanjin, and one doing regu…

This study aimed to compare two over-the-counter hearing aids—the Lexie B3 Pro and a competitor—in adults with mild to moderate hearing loss. Participants would have tested each device and reported their experiences. However, the trial was withdrawn before any participants were e…

This study aims to see if a self-fitting over-the-counter (OTC) hearing aid works as well as a professionally fitted prescription device for adults with mild-moderate hearing loss. The research involves three phases: validating a hearing test, checking user experience, and a rand…

Researchers at Ohio State University are studying how background noise affects speech understanding in adults with normal hearing. About 200 native English speakers aged 18 to 70 will listen to filtered speech in different frequency ranges while noise is added at various levels. …

This study looks at whether a special training program for teachers can help deaf children learn sign language better. About 150 teachers and their deaf students (ages 4-12) are taking part. Teachers are split into two groups: one gets the new training, the other continues as usu…

This study tests a patient navigation program to help rural adults in Kentucky get hearing tests. 500 participants from primary care clinics will receive guidance every two weeks to overcome barriers like travel and cost. The goal is to see if more people complete diagnostic hear…

This study looks at whether a special parent training program can help families with deaf or hard of hearing children aged 3 to 6. The program teaches positive parenting strategies to prevent behavior problems. About 295 parents will take part, and researchers will measure change…

This study looks at whether spinal anesthesia used during planned cesarean deliveries can cause temporary hearing loss. Researchers will test women's hearing before and after the procedure using a standard hearing test. They will also track headaches that can occur after spinal a…

This study follows 88 deaf or hard-of-hearing children who, as toddlers, were randomly assigned to receive a 6-month parent coaching program or standard care. Researchers want to see if the early coaching leads to better language, reading, and social skills when the children reac…

This study tests a new type of cochlear implant that uses light instead of electricity to stimulate the hearing nerve. Researchers hope light can target smaller nerve groups, leading to clearer sound. The trial involves 30 adults who are already having ear surgery for tumor remov…

This study follows 100 people aged 60-85 with mild memory or movement problems to see if losing smell, hearing, or balance speeds up cognitive decline. Researchers will test these senses and track thinking skills and quality of life for 5 years. The goal is to understand which se…

This study aimed to understand how exposure to HIV and antiretroviral therapy in the womb might affect hearing in children who are HIV-free. Researchers planned to test hearing abilities in healthy infants born full-term. However, the study was withdrawn before enrolling any part…

This study, run by Apple and the University of Michigan, tracks headphone and environmental sound exposure in 300,000 US adults using iPhones and Apple Watches. Participants answer surveys and take hearing tests through the Research app. The goal is to understand how everyday sou…

This study looks at how stimulating a nerve in the ear affects pupil size during cochlear implant surgery. Researchers will measure pupil dilation in 30 adults to learn more about the vagus nerve's role in hearing. The goal is to gather knowledge, not to treat hearing loss direct…

This study looks at whether managing cochlear implant care remotely (via phone or app) works as well as going to the clinic. About 148 adults with hearing loss will be followed for a year after their implant is activated. The goal is to see if remote care saves time and money whi…

This study tests a hearing program for older adults who don't have easy access to hearing care. During a primary care visit, participants are screened for hearing loss and then randomly assigned to either get counseling on affordable listening devices or be referred to standard a…

This study looks at how deaf children in kindergarten through 3rd grade develop sign language skills. Eight children from a school for the deaf will receive special sign instruction and have their language progress tracked daily. The goal is to understand how teaching methods aff…

This study follows 39 adults with severe hearing loss who are getting a cochlear implant. Researchers will test their hearing and balance at several points over two years, using both objective tests and patient questionnaires. The goal is to better understand how the implant affe…