Cranial nerve palsy

This study is testing whether stem cells taken from a person's own bone marrow and then given back through the veins and nose can improve brain and nerve function. It includes 500 people with various conditions like stroke, Parkinson's, Alzheimer's, and nerve damage. The goal is …

This study tests an experimental drug called NIO752 in 300 people with progressive supranuclear palsy (PSP), a rare brain disorder that affects movement and balance. Participants are randomly assigned to receive either the drug or a placebo. After the main study, everyone can rec…

This early study tests a spinal cord stimulation therapy called ARC-IM in 5 people with Parkinson's disease or related conditions who experience severe drops in blood pressure when standing (orthostatic hypotension). The main goal is to check safety, and researchers will also mea…

This early-phase study tests a radioactive tracer called 11C-M503 to see if it can detect abnormal alpha-synuclein protein clumps in the brain, which are linked to Parkinson's disease and multiple system atrophy. About 70 adults aged 40-85 with Parkinson's, multiple system atroph…

This study is testing a new blood test to help doctors diagnose Parkinson's disease and similar brain disorders more accurately and earlier. Researchers will use a technique called RT-QuIC to detect misfolded proteins in blood samples from 458 participants, including healthy peop…

This study is testing whether artificial intelligence can help diagnose Parkinson's disease by analyzing facial expressions and speech patterns. Researchers will record videos of 720 participants, including people with Parkinson's and similar conditions, as well as healthy volunt…

This early-phase study tests two new imaging drugs, [18F]ABBV-964i and [18F]ABBV-965i, designed to light up tau protein buildup in the brain during a PET scan. Tau buildup is linked to Progressive Supranuclear Palsy (PSP), a rare movement and thinking disorder. The trial includes…

This early-phase study tests a new radioactive tracer called 18F-JSS20-183A to see if it can safely and accurately detect abnormal tau protein in the brain during PET scans. Researchers will study 90 adults aged 40-85 with tauopathies (like PSP, Alzheimer's, or Parkinson's) and h…

This study is testing a new, non-invasive eye scan to see if it can detect Parkinson's disease in its early stages. Researchers will compare the eye scan results with standard brain imaging in 200 participants, including people with early Parkinson's, related movement disorders, …

This early-phase study tests a new radioactive tracer called 11C-HY-2-15, designed to detect abnormal alpha-synuclein protein in the brain. Researchers will scan 70 adults with multiple system atrophy, Parkinson's disease, progressive supranuclear palsy, or healthy volunteers to …

This study tests whether a personalized form of transcranial magnetic stimulation (TMS) can improve motor and non-motor symptoms in people with Parkinson's disease, multiple system atrophy, or progressive supranuclear palsy. Fifty participants will receive 10 days of targeted TMS…

This study tests whether using virtual reality at home can help people with recent facial palsy (within the last year) reduce involuntary facial spasms called synkinesis. About 100 participants will either use a VR self-rehabilitation program or follow standard rehabilitation exe…

This early study tests a new spring made from surgical stitches to help people with facial nerve palsy close their eyelid. The spring is placed under the skin near the eyelid center, without attaching to bone. Ten adults who cannot blink due to nerve damage will try it, aiming to…

This study tests whether intradermal acupuncture (tiny needles placed under the skin) can improve eye surface symptoms like dryness and irritation in people with long-term facial paralysis. Researchers will compare the real acupuncture to a placebo needle in 78 adults aged 18-65.…

This study compares how different laser frequencies affect nerve recovery in people with Bell's palsy, a condition that causes sudden facial paralysis. Researchers will measure nerve signals in the face before and after treatment. The goal is to find which laser setting works bes…

This study tests whether doing eye exercises in virtual reality can help people with certain eye nerve palsies move their eyes more. The VR scene moves with the person's head while they do visual tasks. The goal is to see if this improves eye movement range. The study involves 40…

This study tests whether adding neuromuscular electrical stimulation (NMES) to standard facial exercises helps people who have facial paralysis after a stroke. About 130 adults with first-time stroke and central facial palsy will be randomly assigned to receive either usual train…

This study tests whether giving vitamin D3 locally and using a minor surgical technique called corticision can make orthodontic tooth movement faster. Sixteen patients aged 13-20 who need premolar extractions will be followed for 12 weeks. The goal is to see if these methods safe…

This study is testing whether Korean integrative medicine, including Chua therapy, can help people with Bell's palsy recover facial movement and emotional well-being. Researchers will follow 100 adults aged 19-69 who have had facial palsy for less than three weeks. The main goal …

This study tests whether a non-invasive brain stimulation technique called tDCS, applied while people walk, can improve motor skills like gait, speech, and eye movements. Twenty adults with progressive supranuclear palsy, corticobasal degeneration, or Parkinson's disease will rec…

This study tests whether a mild electrical brain stimulation technique called tDCS can improve swallowing difficulties in people with Parkinson's disease. 58 participants will receive either real or sham tDCS alongside standard swallowing therapy. Researchers will measure changes…

This study screens 360 adults with neurodegenerative disorders like ALS, frontotemporal dementia, and progressive supranuclear palsy. Researchers will use medical history, physical exams, memory tests, movement analysis, MRI scans, and other tests to find common features and diff…

This study is building a large database of health information from 5,000 people with ALS and other motor neuron diseases. Participants share details like symptoms, test results, and disease progression during regular clinic visits. The de-identified data is then shared with resea…

This study uses eye-tracking technology to see how people with facial palsy pay attention to faces with abnormal movement, compared to healthy volunteers. Researchers want to understand if patients focus differently on the affected side of the face. The goal is to learn more abou…

This study looks at whether new, quick tests that measure how fast people can move can help doctors diagnose brain diseases like Alzheimer's and predict recovery after a stroke. Researchers will test 129 adults aged 40-85 with stroke or memory problems. The goal is to see if thes…

This study uses special PET scans to measure tau protein buildup in the brains of 332 people with Progressive Supranuclear Palsy (PSP), a rare brain disorder that affects movement and balance. Researchers want to see how tau levels change over time and relate to symptoms. Partici…

This study follows nearly 3,000 people, including healthy adults and those with memory or movement problems, to learn how brain diseases like Alzheimer's and Parkinson's develop. Researchers use advanced brain scans and tests to track changes over time. The goal is to improve ear…

This study uses a new ultra-high-resolution PET scanner to take detailed pictures of the brain and spinal cord in 300 healthy volunteers and people with conditions like Alzheimer's, Parkinson's, ALS, and psychotic disorders. The goal is to understand how small brain regions chang…

This study aims to find early markers of Parkinson's disease, multiple system atrophy, and Lewy body dementia by analyzing samples from the nose, blood, and urine. Researchers will compare results from 180 people with these conditions and healthy volunteers. The goal is to improv…

This study is gathering information from 700 people with Parkinson's disease or similar conditions who experience freezing of gait—a sudden inability to move their feet while walking. Researchers will track symptoms, walking patterns, and falls over three years using questionnair…

This study aims to find genes that cause eye misalignment (strabismus) and related conditions involving the cranial nerves and brainstem. Researchers will analyze DNA from up to 20,000 participants with these disorders. The goal is to better understand the genetic causes, which c…

This study uses special brain scans to measure damage to nerve connections in people with Multiple System Atrophy (MSA) and Progressive Supranuclear Palsy (PSP). Researchers will scan 36 adults aged 45-80 to see how the disease changes over time. The goal is to better understand …

This study is testing whether artificial intelligence (AI) can analyze brain scans to help diagnose Parkinson's disease and related conditions like multiple system atrophy. Researchers will also see if the scans can predict how fast the disease will progress. The study involves 9…

This study collects information and samples from 1,000 people with or at risk for brain diseases like Alzheimer's, ALS, and frontotemporal degeneration. Researchers will track changes in thinking, language, and brain scans over time. The goal is to build a resource for future stu…

This study uses a special MRI technique called diffusion tensor imaging to map cranial nerves before skull base tumor surgery. Researchers will compare the nerve positions seen on MRI with what surgeons actually find during the operation. The goal is to see if this imaging can he…

This study collects DNA from up to 1,000 adults with progressive supranuclear palsy (PSP), corticobasal syndrome (CBS), multiple system atrophy (MSA), or related conditions, plus their family members. Researchers will sequence participants' whole genomes to find genetic variants …

This study is testing whether new brain imaging techniques can better diagnose diseases like Parkinson's, multiple system atrophy, and frontotemporal dementia. Researchers will use MRI scans and neurological exams in about 94 adults aged 40-85. The goal is to improve how doctors …

This study is looking for 500 people with early dementia or mild cognitive impairment to help develop a way to predict how their disease will progress. Researchers will use blood tests and other models to better understand each person's outlook. The goal is to give patients and d…