Barrett esophagus

This early-phase trial investigates whether itraconazole, a common antifungal medication, can reduce the risk of cancer in people with high-risk Barrett's esophagus who have already undergone endoscopic ablation. Barrett's esophagus often returns after treatment, increasing the c…

This phase 2 trial tests whether taking aspirin can prevent Barrett's esophagus from returning after it has been successfully removed with radiofrequency ablation. Researchers will measure levels of a protein linked to Barrett's in tissue samples from 21 participants over 12 mont…

This study tests whether a minimally invasive procedure called Transoral Incisionless Fundoplication (TIF) can reduce acid reflux and prevent Barrett's esophagus from coming back after successful ablation. Barrett's esophagus is a precancerous condition where the lining of the es…

This study tests a freezing device (CryoBalloon) to treat Barrett's esophagus that hasn't improved after multiple standard heat treatments. About 70 adults with precancerous changes in the esophagus will receive the freezing therapy. The goal is to safely remove all abnormal tiss…

This study tests a device that freezes abnormal cells in the esophagus to treat Barrett's esophagus, a condition that can lead to cancer. About 62 adults with low- or high-grade dysplasia (precancerous changes) will receive the treatment. The goal is to see if the freezing balloo…

This study looks at whether ablation therapy (using heat or light to destroy abnormal cells) can control Barrett's esophagus, a condition that can lead to esophageal cancer. About 600 adults with high-grade dysplasia or early cancer will be treated and followed to see if the abno…

This study is testing a simple, less invasive way to detect Barrett's esophagus and esophageal cancer using a sponge on a string. Participants swallow the sponge, which collects cells from the esophagus. Researchers will analyze these cells to develop a lab test that can spot ear…

This study tests a device called Endosign, which is a sponge on a string that patients swallow to collect cells from the esophagus. The goal is to see if this simple, non-sedation method can provide good enough samples to replace regular endoscopies for monitoring Barrett's esoph…

This study looks at whether a simple, swallowable device can help screen for esophageal cancer in rural Oregon, where getting a traditional endoscopy is hard. About 110 adults with chronic heartburn and other risk factors will try the device at their local clinic. Researchers wan…

This study is testing a new, less invasive way to screen for Barrett's esophagus, a condition that can lead to esophageal cancer. Participants swallow a small capsule attached to a thin string, which takes pictures of the esophagus. The goal is to see if this method is comfortabl…

This study tests a special imaging capsule (OFDI) that patients swallow to take detailed pictures of the esophagus. The goal is to see if it can accurately detect Barrett's esophagus, a condition that can lead to cancer. Researchers will compare the capsule's images with standard…

This study collects blood and tissue samples from 1,000 adults with Barrett's esophagus or esophageal cancer during their routine endoscopy. The goal is to build a biorepository that links clinical data with specimens, enabling future research into these conditions. Participants …

This study aims to find early DNA changes in blood and esophageal tissue that could signal a higher risk of developing esophageal cancer. Researchers are studying 600 people with gastroesophageal reflux, Barrett's esophagus, or esophageal cancer who are already scheduled for an u…

This study looks at genetic changes in people with H. pylori infection or stomach cancer to understand how the infection can lead to cancer. Researchers will analyze tissue samples from 110 adults undergoing endoscopy. The goal is to find early warning signs and possible ways to …

This study looks at 200 male FDNY rescue workers who were exposed to dust and toxins after the World Trade Center attacks. Many developed acid reflux, which can lead to Barrett's esophagus and even cancer. Researchers will use simple, noninvasive tests like saliva samples and que…

This study is a registry that will review medical records of 1,000 patients treated for benign or malignant gastrointestinal diseases between 2005 and 2030. Researchers will look at survival, symptoms like heartburn and swallowing trouble, and quality of life. The goal is to lear…

This study examines tissue samples from 25 people with Barrett's esophagus (a condition where the lining of the food pipe changes) to find cell and gene changes linked to the disease. Participants provide a small tissue sample during a routine endoscopy. The goal is to better und…

This study is creating a large registry of 2,000 people with gastroesophageal reflux disease (GERD) and related conditions like Barrett's esophagus. Researchers will collect data from medical records and questionnaires over 5 years to better understand the disease and its treatme…

This study tracks 500 adults with conditions like acid reflux, achalasia, or complications after weight-loss surgery. Participants choose either a newer endoscopic procedure (done through a scope) or standard surgery. Researchers will compare how well each approach controls sympt…

This study aimed to test a special camera capsule that takes detailed images of the esophagus to diagnose eosinophilic esophagitis and Barrett esophagus. It planned to compare the capsule's images with standard biopsy results. However, the study was withdrawn before any participa…

This study follows 500 adults with Barrett's esophagus for 3 years using a tethered capsule endomicroscopy device—a pill-sized camera that patients swallow. The goal is to track how the condition changes over time without needing sedation or a traditional endoscopy. Researchers h…

This study follows 100 adults with Barrett's esophagus, a condition where the lining of the food pipe changes, to see how it naturally progresses. Participants swallow a small camera in a capsule that takes pictures of the esophagus during routine check-ups. The goal is to learn …