Allergic rhinitis

This early-stage study tests a new vaccine called PollenVax for people with moderate to severe mugwort pollen allergy. The main goal is to see if the vaccine is safe and tolerable in 30 adults aged 18 to 65. Participants receive four shots of either the vaccine or a placebo, and …

This study looked at whether the HPV vaccine works in girls aged 9 to 17 who are taking medicines that weaken their immune system, such as after an organ transplant or for diseases like lupus. The goal was to see if their bodies produce enough antibodies to protect against HPV. T…

This study looked at 84 people with severe allergic rhinitis (constant sneezing, runny nose, itching, stuffiness) that didn't improve with usual treatments. Researchers compared three procedures that target the nerve in the nose: surgical cutting, radiofrequency, and surface cobl…

This study tested whether analyzing a patient's DNA and RNA could help doctors pick the right drug for inflammatory diseases that don't fit standard categories. 32 adults with at least two affected organs (including skin) received one of six targeted therapies based on their mole…

This study tested a type of allergy immunotherapy (Clustoid® Max Forte) in 140 people aged 5 to 65 with dust mite allergies. The goal was to see if it reduces allergy and asthma symptoms and the need for medication over one year. Results were measured by symptom scores and medica…

This study tested a dietary supplement containing immune-supporting nutrients and postbiotics in 40 children aged 5–12 with asthma and/or allergic rhinitis. The goal was to see if the supplement could improve symptom control over 6 months. Researchers also looked at changes in im…

This study looked at how well a new, quick finger-prick test (LumiraDx CRP) measures CRP levels compared to a standard lab test. CRP is a marker of infection, inflammation, or tissue injury. 79 adults with symptoms of these conditions took part. The goal was to see if the new tes…

This early study tested a new radioactive tracer called 18F-FDS in 16 people with suspected bacterial or fungal infections. The tracer is designed to light up infection sites on PET/CT scans, helping doctors see exactly where an infection is. The goal was to check how the tracer …

This study tests whether a probiotic gummy containing Weizmannia coagulans BC99 can reduce symptoms of allergic rhinitis (hay fever) in children aged 4 to 14. Over 8 weeks, half the children receive the probiotic gummy and half receive a placebo. Researchers track changes in nasa…

This study tested whether adding thread embedding acupuncture (TEA) to standard steroid nasal spray helps people with allergic rhinitis. 64 adults took part. The goal was to see if the combination reduces symptoms like sneezing and stuffy nose better than the spray alone, and whe…

This study tested whether a home-use light device (rhinophototherapy) can reduce nasal inflammation and allergy symptoms as well as a standard steroid spray. Thirty-five adults with allergic rhinitis used either the light device for 4.5 minutes three times daily or a steroid spra…

This study tested whether adding a decongestant nasal spray for the first 5 days to standard steroid spray treatment helps children with persistent allergic rhinitis feel better faster. 76 children aged 4-18 were randomly assigned to receive either steroid spray alone for 4 weeks…

This completed trial tested whether a probiotic called Bifidobacterium longum ES1, or its heat-treated version, could reduce symptoms of allergic rhinitis (hay fever) in 72 adults with moderate-to-severe dust mite allergies. Participants took daily capsules for several weeks and …

This study tested an investigational treatment called PQ Grass 27600 SU in 119 adults with seasonal grass pollen allergies (hay fever). The goal was to see if it could reduce allergy symptoms and the need for relief medications during peak grass pollen season. Participants receiv…

This study tested an experimental nasal spray called INI-2004 in 78 adults with ragweed allergies. Participants received either the spray or a placebo once a week for four weeks, then spent time in a room filled with ragweed pollen to see if symptoms improved. The goal was to che…

This study looked at whether taking a grass pollen tablet (SLIT) together with the drug dupilumab for 2 years can help adults with moderate to severe hay fever tolerate grass pollen better, even after stopping treatment. About 199 participants were involved. The main goal was to …

This study tested a nasal spray made from pistacia lentiscus oil (Bactorinol) in 120 adults with vasomotor rhinitis, a chronic condition causing nasal congestion and runny nose. Participants used the spray or a saline placebo for 20 days. The goal was to see if the oil spray impr…

This study tested Xolair (omalizumab) in 50 teenagers aged 12 to 17 with severe seasonal allergic rhinitis (hay fever) that standard treatments couldn't control. Researchers tracked side effects and how much symptoms improved. The goal was to see if Xolair is safe and effective i…

This small study tested whether acupuncture can relieve nasal congestion in people with allergic rhinitis. Eleven adults received either acupuncture or a standard nasal spray for 6 weeks. The goal was to see if acupuncture offers a safe, side-effect-free option for stuffy noses.

This study tested whether a supplement called M-Gard can help relieve symptoms of seasonal grass pollen allergies (hay fever). Twenty healthy adults with a history of grass allergies took M-Gard or a placebo in a crossover design. Researchers measured symptom severity like nasal …

This study looked at whether giving a low dose of a muscle relaxant (rocuronium) during bronchoscopy—a procedure where a tube is inserted into the lungs—could reduce complications like throat spasms and coughing. 153 adults having elective bronchoscopy were split into two groups:…

This study tested the safety and effectiveness of Allegra D (fexofenadine plus pseudoephedrine) in 203 people aged 12 and older with allergic rhinitis. Participants took the medication for up to 13 days, and researchers tracked side effects and symptom improvement using nasal and…

This study tested a new drug called BLU-808 in 21 adults with ragweed allergies. The goal was to see if it is safe and helps reduce sneezing, runny nose, and itchy eyes caused by ragweed pollen. Participants were exposed to ragweed in a special chamber to measure the drug's effec…

This Phase 2 trial tested an injection called TQC2938, a humanized monoclonal antibody, in 136 adults with seasonal allergic rhinitis. All participants also used a standard nasal spray. The study measured how well the injection reduced nasal symptoms like sneezing and congestion …

This study tested whether apple fruit extract, which has antioxidant and anti-inflammatory properties, could improve symptoms of allergic rhinitis (hay fever). Forty adults with persistent allergies received either standard treatment plus apple extract or standard treatment alone…

This study tested whether Ectoin allergy nasal spray and eye drops can relieve symptoms of hay fever (runny nose, sneezing, itchy eyes) better than a placebo. 46 adults with ragweed allergies were exposed to pollen in a special chamber. Researchers measured symptom scores and nas…

This study tested whether an ectoine nasal spray works better than a cromoglycic acid spray for easing allergic rhinitis symptoms like a stuffy nose, runny nose, and sneezing. Fifty adults with proven allergies used one of the two sprays for 14 days. Doctors and patients rated ho…

This early-stage study tested a new drug called INI-2004 in 68 healthy people and those with ragweed allergies. The goal was to check safety and how well it reduces nasal symptoms like sneezing and congestion. Researchers gave single or multiple doses and monitored side effects a…

This early-stage trial tested the safety and tolerability of a new corticosteroid nasal spray called PA9159 in 36 healthy Chinese adults. Participants received either a single dose or seven daily doses of the spray, or a placebo. The goal was to find the maximum safe dose and see…

This study tested a drug called omalizumab in 337 adults and teens with severe Japanese cedar pollen allergy (hay fever) that standard medicines couldn't control. Participants received either omalizumab or a placebo on top of their usual allergy treatments for 12 weeks. The goal …

This study tested whether the drug TAU-284 (bepotastine besilate) can reduce sneezing, runny nose, and congestion in children aged 7 to 15 with perennial allergic rhinitis (year-round nasal allergies). In a double-blind, placebo-controlled design, 473 children took either the dru…

This study tested a medicine called TAU-284 in 490 children aged 7 to 15 who have year-round nasal allergies. The goal was to see if it reduces sneezing, runny nose, and congestion better than a placebo. The trial was completed and focused on symptom relief, not a cure.

This study tested the long-term safety and effectiveness of TAU-284 (bepotastine besilate) in 58 children aged 7 to 15 with perennial allergic rhinitis (year-round nasal allergies). Over 12 weeks, researchers tracked side effects and changes in sneezing, runny nose, and congestio…

This study tested a new drug called LP-003 in 180 adults with moderate to severe seasonal allergic rhinitis (hay fever) that wasn't well controlled by usual treatments like antihistamines or nasal sprays. LP-003 is an antibody that blocks IgE, a key driver of allergic reactions, …

This early-stage study tested a single dose of the investigational drug MT-2990 in 75 adults with seasonal allergic rhinitis triggered by Japanese cedar pollen. The main goals were to check the drug's safety, how the body processes it, and whether it can reduce allergy symptoms w…

This study tested a medication called STALORAL Birch 300 IR in 553 children aged 5 to 17 with birch pollen allergies. The goal was to see if it safely reduces symptoms like sneezing, runny nose, and itchy eyes during pollen season. Participants received the treatment or a placebo…

This study looked at whether children with year-round allergic rhinitis can use a nasal steroid spray only when symptoms bother them, instead of every day. Sixty-eight children aged 6 to 18 were randomly assigned to either daily use or as-needed use of fluticasone furoate spray. …

This completed study tested whether probiotic gummies can relieve allergic rhinitis symptoms in children aged 4 to 14. Over 56 days, 72 kids took either the probiotic or a placebo, and researchers tracked nasal symptoms, quality of life, and gut health. The goal was to see if pro…

This study tested whether a low dose of IL-2 (a protein that helps regulate the immune system) could reduce nasal symptoms in people with birch pollen allergy. Twenty-four adults with a history of seasonal allergies received either the drug or a placebo over several months. The g…

This study tested a nasal spray called AD17002 in 48 adults with house dust mite allergic rhinitis. The goal was to see if it is safe and can reduce symptoms like sneezing, runny nose, and congestion. Participants received either the spray or a placebo, and researchers monitored …

This study tested whether taking the allergy drug fexofenadine for two days before ragweed season can reduce symptoms like sneezing and runny nose. 95 adults with ragweed allergies were randomly given either fexofenadine or a placebo. Researchers measured nasal symptoms over six …

This completed study looked at how the social networks of caregivers affect their stress and health when caring for someone with an inherited disease. Researchers surveyed over 680 participants, including family members and formal caregivers, to understand caregiving burden and s…

This study investigates whether spores from birch rust fungi trigger seasonal allergies in autumn. Researchers will compare 30 people with suspected birch rust allergy to 15 non-allergic controls, tracking symptoms and spore levels. The goal is to understand a possible cause of a…

This completed study looked at whether substances in nasal fluid can help doctors objectively measure the severity of respiratory conditions like asthma, COPD, hayfever, and sinusitis. Researchers collected samples from 111 adults (including healthy volunteers) using a small nasa…

This study looked at gene activity in cells from the nose and lungs of 44 healthy and allergic adults. The goal was to understand how allergies change these cells and why the nose and lungs react differently. Researchers hope this knowledge will lead to better treatments for alle…

This study surveyed 500 parents of children with asthma or allergic rhinitis to see how much they know about air quality and pollution. The goal was to understand their awareness, knowledge, and protective behaviors. The results will help design better education and prevention pr…

This study looked at whether a home visit by an environmental counselor can improve the quality of life for children with asthma or allergic rhinitis. Researchers checked the children's health at the start and again six months after the visit using standard questionnaires. The st…

This completed Phase 1 study tested whether two substances in the blood (sST2 and miR-223) can help predict how well patients with dust mite allergies respond to a six-month course of under-the-tongue immunotherapy (SLIT). Fifty-four patients with moderate-to-severe allergic rhin…

This study looked at how the body naturally stops allergic inflammation after being exposed to grass pollen. Researchers measured specific molecules in the nose that help control and resolve the allergic response. Twenty adults with grass pollen allergies participated. The goal w…

This study collected blood, saliva, stool, urine, and skin samples from 19 people with unknown or poorly understood immune system problems. The goal was to learn how different parts of the immune system work together. No treatments or drugs were tested. Participants were followed…

This study observed how private pediatricians in France manage allergic rhinitis (hay fever) in children under 18. Over 1,000 children participated, and researchers collected data on current treatment practices, including how many kids might be eligible for allergy immunotherapy.…

This study aimed to find the right strength of two grass allergen extracts (timothy and orchard grass) to cause a skin reaction similar to histamine. Thirty-one adults with grass pollen allergies received skin prick tests with different concentrations. The goal was to improve all…

This study examined 69 children aged 6 to 14 to see if a deviated nasal septum (a crooked wall inside the nose) is linked to allergic rhinitis (hay fever). Researchers compared kids with and without the deviation using allergy tests, nasal samples, and quality-of-life questionnai…

This completed study tested whether a dissolved allergy tablet (Itulazax) can be used as a nasal spray to diagnose birch pollen allergy. 89 participants received either the dissolved tablet or a saltwater spray, and their nasal symptoms and airflow were measured. The goal was to …