Allergic rhinitis

This early-stage study tests a new drug called cizutamig in about 20 adults with IgE-mediated allergies, including food allergies. The main goal is to see if the drug can safely lower IgE levels, which are antibodies that trigger allergic reactions. Researchers will also monitor …

This trial compares three FDA-cleared in-office procedures that treat chronic non-allergic rhinitis by targeting the posterior nasal nerve. Radiofrequency ablation (using RhinAer or Neuromark) uses heat, while cryoablation (ClariFix) uses extreme cold to reduce nerve signals that…

This study tests whether digital tools can help people with allergic rhinitis (hay fever) better control their symptoms. About 240 adults will use a smartphone platform that tracks symptoms, sends reminders, and gives personalized advice. Researchers will compare their progress t…

This 5-year study is looking at how well a year-round allergy treatment (MATA trees or MATA grass) works for children and adults with pollen allergies, including hay fever and mild asthma. Researchers want to see if the treatment is as effective in kids as it is in adults. About …

This phase 3 study tests lebrikizumab, an injectable drug, in 450 adults with perennial allergic rhinitis (year-round allergies). The goal is to see if it reduces nasal symptoms like congestion and sneezing compared to a placebo. Participants will be followed for up to 29.5 month…

This phase 3 trial tests a daily tablet that dissolves under the tongue to treat house dust mite allergies. It includes 327 Chinese participants aged 12-65 with allergic rhinitis, with or without asthma. The goal is to see if the tablet reduces allergy symptoms and the need for o…

This study tests whether adding moxibustion—a traditional heat therapy—to standard allergy medicine can safely reduce symptoms like sneezing, stuffiness, and runny nose in people with allergic rhinitis. About 60 adults with a cold-type allergy will receive either standard care al…

This early-stage trial tests a new biologic drug called ASP2390, given as a skin injection, in 28 adults with house dust mite allergies. The main goal is to check safety and how the immune system responds, not yet whether it works. If successful, it could lead to a new way to eas…

This Phase 2 trial tests whether an injection called DM-101PX can reduce nasal symptoms caused by birch pollen allergy. About 100 adults with birch pollen allergic rhinitis or rhinoconjunctivitis will receive either the drug or a placebo. The main goal is to see if the treatment …

This study tests whether taking oral probiotics can reduce symptoms of allergic rhinitis (hay fever) and improve quality of life. Researchers will give probiotics to 225 people aged 6 to 65 with diagnosed allergic rhinitis and measure changes in nasal symptoms, inflammation marke…

This study looks at whether a breathing technique used by free divers can reduce symptoms of allergic rhinitis, like nasal congestion and sneezing. Thirty adults with persistent allergies will practice the 40-minute breathing sessions. Researchers will measure symptom scores, nas…

This study compares two nasal sprays for moderate-to-severe allergic rhinitis (hay fever): fluticasone alone versus a combination of fluticasone and azelastine. Researchers will track symptom relief and quality of life in 61 adults over two months to see which spray works better …

This study tests a new injection called LP-003 in 6 teenagers aged 12 to 18 who have allergies like hay fever, asthma, or eczema. The main goal is to check if the drug is safe and how the body processes it. This is an early-stage trial, so it focuses on safety and drug levels rat…

This study tests a procedure called RhinAer that uses heat to treat the nerves in the nose for people with chronic rhinitis (long-term stuffy or runny nose). Researchers want to see if it reduces inflammation and improves symptoms like cough and post-nasal drip. About 25 adults a…

This pilot study tests whether tezepelumab, a drug already approved for severe asthma, can also reduce nasal symptoms caused by hayfever in people who have both allergic asthma and allergic rhinitis. Nineteen participants will receive monthly injections of tezepelumab for 12 mont…

This study tests an experimental injection called LP-003 in 546 adults with moderate to severe seasonal allergic rhinitis (hay fever) that standard medications don't manage well. Participants receive either the drug or a placebo, and report their nasal symptoms daily. The goal is…

This study was designed to see if a combination of levocetirizine (an allergy medicine) and pseudoephedrine (a decongestant) works better than levocetirizine alone for relieving nasal congestion in people with allergic rhinitis. It planned to enroll people aged 12 to 65 with the …

This study tests a laser procedure that targets nerves in the nose to relieve chronic rhinitis symptoms like runny nose, sneezing, and stuffiness. 120 adults who haven't gotten relief from standard medications will receive either the laser treatment or a sham procedure. Researche…

This study tests a new epinephrine nasal powder (FMXIN002) against the standard EpiPen injection in 50 healthy adults with allergies. Researchers will measure how quickly and effectively the nasal spray delivers epinephrine into the body and its effects on vital signs. The goal i…

This study tests a new treatment called GNR-127 for people with seasonal allergies to birch pollen. The treatment is a protein that aims to reduce allergy symptoms like sneezing, runny nose, and itchy eyes. The trial involves 150 adults and will check for safety and how well it w…

This study looks at how dupilumab changes the way the nose and blood respond to house dust mites in adults with allergic asthma. Participants will be exposed to dust mites in a special chamber and receive either dupilumab or a placebo. The goal is to understand the drug's effects…

This study looks at the bacteria living in the nose and sinuses of people with chronic sinusitis, allergies, and healthy individuals. By analyzing tissue samples from 285 participants, researchers hope to identify which bacteria are linked to long-term inflammation. The goal is t…

This study aims to see if a special cat allergen extract (AP Cat) can cause hay fever symptoms when sprayed into the nose of people with cat allergies. Twenty volunteers—some allergic to cats, some not—will receive the extract and have their symptoms and allergy markers measured.…