Acquired peripheral neuropathy

This completed Phase 3 study tested TAK-771, a combination of immune globulin and hyaluronidase, in 26 Japanese adults with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) or multifocal motor neuropathy (MMN). The main goals were to check for side effects and see…

This phase 2 trial tests an experimental drug called ARGX-117 in 54 adults with multifocal motor neuropathy (MMN), a condition that causes muscle weakness. Participants receive either ARGX-117 or a placebo by IV, and researchers check if the drug can safely delay the need for sta…

This study tested whether a diode laser can act as a biomarker to measure neuropathic pain in people with peripheral neuropathy. Researchers compared pain responses to a lidocaine patch versus a placebo patch in 75 participants. The goal was to see if the laser test could disting…

This study tested whether taking gabapentin along with oxcarbazepine works better than oxcarbazepine alone for trigeminal neuralgia, a condition causing severe facial pain. 44 adults were split into two groups and had their pain measured over 2 months. The goal was to see which a…

This completed study tested a laser device (BTL-043) on 31 adults with temporomandibular joint (TMJ) pain. Participants received four 20-minute laser sessions over a few weeks. Researchers measured pain levels, jaw movement, and daily function at 1 and 3 months after treatment to…

This study tested whether applying antibiotics directly into the tooth socket after wisdom tooth removal works as well as taking antibiotic pills. 90 adults having their lower wisdom teeth taken out were split into two groups: one got antibiotic gel at the surgery site, the other…

This study tested a new drug called SR750 in 138 people with trigeminal neuralgia, a condition that causes sudden, severe facial pain. Participants took either SR750 or a placebo for 6 weeks and recorded their daily pain levels. The goal was to see if SR750 reduces pain better th…

This study tested a minimally invasive procedure called pulsed radiofrequency on a nerve bundle in the face (the sphenopalatine ganglion) to see if it could reduce pain in 55 people with chronic headaches or facial pain who hadn't gotten relief from medication. The procedure uses…

This study tested a device called SinuSonic that combines sound vibrations with gentle pressure to help people with Eustachian tube dysfunction (ETD) and facial pain. Thirty adults used the device twice a day for six weeks. Researchers measured changes in symptoms like ear pressu…

This study tested a drug that blocks a pain-signaling protein (CGRP) in 26 adults with trigeminal or glossopharyngeal nerve pain caused by small fiber neuropathy or fibromyalgia. The goal was to see if it reduces pain and the need for other pain medications, while checking for si…

This study tested whether low-level laser therapy, combined with a self-care program, could help people with jaw joint pain (TMJ disorders). 66 adults with recent jaw muscle pain received the treatment. Researchers measured pain levels, jaw movement, and tender spots to see if th…

This study tested two different modes of transcutaneous electrical nerve stimulation (TENS) to relieve chronic pelvic pain in 60 men who had prostate surgery. Participants received TENS sessions three times a week for three months. The goal was to see which mode works better for …

This completed study tested whether botulinum toxin type-A injections relieve pain from myofascial pain syndrome better than a standard local anesthetic (prilocaine). Thirty-eight adults with long-term muscle pain were randomly assigned to receive either botulinum toxin or priloc…

This study tested whether a combination of nucleotides and B vitamins (Nucleo CMP and Neurorubine) could provide better and longer-lasting pain relief than the standard drug carbamazepine for people with trigeminal neuralgia, a severe facial pain condition. 38 adults with classic…

This completed study examined muscle cells from 8 children with obstetrical brachial plexus palsy, a birth injury that affects arm nerves. Researchers took small muscle samples during planned shoulder surgery to see if the cells can repair themselves. The goal was to understand w…

This study used a special ultrasound technique to measure stiffness in pelvic floor muscles of 94 women — some healthy and some with pudendal neuralgia, a chronic nerve pain condition. Researchers compared the muscle stiffness between the two groups to see if differences exist. T…

This study looked at 20 adults with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) or multifocal motor neuropathy (MMN) who were starting intravenous immunoglobulin (IVIg) treatment. Researchers measured changes in IgG levels in the blood after the first dose to…

This study looked at 150 patients who had surgery for trigeminal neuralgia, a condition causing severe facial pain. Surgeons used a Teflon implant to cushion a blood vessel pressing on a nerve. The study compared two ways of placing the Teflon—either directly against the nerve or…

This study looked at whether the Duruöz Hand Index, a simple questionnaire, can reliably measure hand function in children aged 6-18 with obstetric brachial plexus palsy, a nerve injury at birth. Researchers tested 21 children using various hand strength and function tests. The g…