Yonsei University

This study tests a chemotherapy combination (pemetrexed and cisplatin) in people with advanced or recurrent soft tissue sarcoma that has not responded well to previous treatments. The goal is to see if this drug pair can slow or stop tumor growth. About 164 adults with specific s…

This study tests whether adding the experimental drug SLC-3010 to the standard drug axitinib works better than axitinib alone for people with advanced clear cell kidney cancer that has worsened after first treatment. About 78 adults will be randomly assigned to one of the two gro…

This study looks at whether slightly raising blood pressure after a stroke clot removal procedure helps patients recover better than the usual approach. About 176 adults who had a stroke and whose blood pressure stays low after the procedure will be randomly assigned to either a …

This study tests adding the immunotherapy drug durvalumab to standard chemotherapy and radiation before surgery for people with stage III non-small cell lung cancer. The goal is to see if this combination is safe and can improve outcomes like tumor shrinkage and survival. Researc…

This study tests a new combination therapy for people with advanced head and neck cancer caused by HPV. The treatment includes a DNA vaccine (GX-188E), an immune booster (GX-I7), and an immunotherapy drug (nivolumab). The goal is to see if this combination can shrink tumors and h…

This study tests a precise type of radiation called carbon ion radiotherapy for people with liver cancer that still has active tumors after a prior treatment called TARE. The goal is to see if this approach can safely shrink or control those remaining tumors. About 48 adults with…

This study is testing whether a drug called Enavogliflozin, currently used for diabetes, can help prevent atrial fibrillation (an irregular heartbeat) from coming back after a catheter ablation procedure in people who also have heart failure. About 390 adults aged 19 to 85 will b…

This study looks at whether low or moderate doses of statins work better and cause fewer muscle problems in healthy adults aged 70 and older who have high cholesterol or heart disease risk. About 724 participants will take either a low or moderate statin and be monitored for musc…

This study tests a drug called lazertinib, given alone or with chemotherapy, before surgery for people with a specific type of lung cancer (EGFR-mutated non-small cell lung cancer). The goal is to see if the treatment shrinks the tumor enough to improve surgery results. About 160…

This study tests whether a smartphone app-based care plan helps people with atrial fibrillation (AFib) recover better after a heart ablation procedure called FARAPULSE. About 500 adults who are getting their first FARAPULSE treatment will be randomly assigned to standard care or …

This study looks at how long people with advanced chronic kidney disease should take two blood thinners (aspirin plus clopidogrel or prasugrel) after getting a heart stent. About 900 adults with severe kidney disease will be randomly assigned to either a short or long course of d…

This study tests a precise form of radiation called carbon ion radiotherapy in 33 frail adults with pancreatic cancer who cannot have surgery or standard chemotherapy. The goal is to see if this treatment can help control the tumor and improve survival with fewer side effects. Pa…

This study tests if a newer pacing method, left bundle branch area pacing (LBBAP), is better than standard right ventricular pacing (RVP) for people who need a pacemaker most of the time. The goal is to see if LBBAP reduces the risk of death, heart failure, or heart muscle damage…

This study tests whether the immunotherapy drug dostarlimab, given alone or with bevacizumab, works better than standard chemotherapy for people with recurrent gynecological clear cell carcinoma (a rare cancer of the ovary, uterus, cervix, vagina, or vulva). About 198 participant…

This study looks at whether a new acid-reducing medicine called zastaprazan works better than standard drugs (PPIs) at keeping blood thinners working properly in heart patients. About 100 adults with chronic heart disease who recently had a stent placed will take either zastapraz…

This study is for people with advanced liver cancer that cannot be removed by surgery. It combines a precise type of radiation (carbon ion radiotherapy) with two standard drugs (atezolizumab and bevacizumab) to see if the radiation helps control the tumor better. About 52 adults …

This study looks at two common blood thinners, aspirin and clopidogrel, to see which one better prevents small blood clots on the new heart valve after a TAVR procedure. About 254 people with severe aortic stenosis will take both drugs for 4 weeks after surgery, then switch to ju…

This study tests a new drug, trastuzumab deruxtecan (T-DXd), in people with recurrent ovarian cancer whose tumors have stopped responding to PARP inhibitors. T-DXd targets a protein called HER2 found on some cancer cells. The trial compares T-DXd to standard chemotherapy to see w…

This study tests whether the immunotherapy drug nivolumab can help people with advanced nasopharyngeal cancer who still have signs of cancer after standard chemotherapy and radiation. About 57 adults aged 19 and older will receive nivolumab infusions. The main goal is to see if t…

This study compares robot-assisted nipple-sparing mastectomy to the traditional open surgery for women with early-stage breast cancer (stage 0 to IIIa) who want immediate breast reconstruction. About 790 participants will be randomly assigned to one of the two surgical methods. T…

This study compares two treatments for people who have had a heart stent placed: a high-intensity statin alone versus the same statin plus ezetimibe. The goal is to see if the combination therapy better prevents death, heart attacks, strokes, or the need for additional procedures…

This study tests a new ultrasound technique called Fluctuational Imaging (FLI) to see if it can accurately diagnose hepatic hemangiomas, the most common benign liver tumor. Currently, many patients need contrast CT or MRI for a clear diagnosis, which adds cost and radiation. The …

This study tests whether a 6-week exercise program can improve exercise capacity and quality of life in people with nontuberculous mycobacterial pulmonary disease (NTM-PD), a chronic lung infection. Researchers will enroll 50 adults aged 40-80 and randomly assign them to start ex…

This study compares two methods to guide balloon treatment for blocked leg arteries in people with chronic limb-threatening ischemia (severe wounds). One method uses standard X-ray images; the other adds a pressure wire to measure blood flow. The goal is to see which approach bet…

This study tests whether a friendly chatbot app can help high-risk drinkers cut back on alcohol. About 220 adults who want to drink less will use the app for 4 weeks, and researchers will check their drinking habits after 16 weeks. The goal is to see if the app's motivational con…

This study tests whether a medicine called pegfilgrastim can prevent a dangerous drop in white blood cells (febrile neutropenia) in women with triple-negative breast cancer who are receiving a specific chemotherapy regimen. About 40 adult patients will receive pegfilgrastim after…

This study is creating a registry of 500 adults with rare cancers in Korea. Researchers will track how many patients go on to join clinical trials. No treatment or experimental drug is given—the goal is simply to collect information and improve future research.

This study looks at 25 people with Fabry disease, a rare genetic condition that can damage the heart. Participants will take a drug called agalsidase alfa for 12 months. Researchers will use special heart scans (PET-CMR) at the start and after one year to see if the drug reduces …

This study looks at whether a special map called a dynamic coronary roadmap can help doctors perform heart artery pressure tests more quickly. About 226 adults with narrowed heart arteries will be randomly assigned to get the map or not during their procedure. The main goal is to…

This study looks at how a wearable robotic hip device affects the way healthy adults walk. Researchers will measure step length, speed, muscle activity, and foot pressure under different levels of assistance from the exoskeleton. The goal is to understand how the device changes n…

This study looks at whether special insoles that measure how you walk, along with other health information, can predict how much your knee will improve after replacement surgery. About 200 adults with knee osteoarthritis scheduled for surgery will participate. The goal is to help…

This study compares two types of educational videos for people about to start radiation therapy: one made with an AI avatar and another using standard slides with voiceover. About 136 patients will watch one of the videos and answer questions about their anxiety and understanding…