Yonsei University

This study tests whether adding bevacizumab (Onbevzi) to standard chemotherapy (gemcitabine and docetaxel) can shrink tumors better than chemo alone in people with advanced soft tissue sarcoma. About 92 adults who have had 1-2 prior treatments will be randomly assigned to one of …

This early-phase trial tests a new way to deliver carbon-ion radiation for prostate cancer, using just 6 sessions instead of the usual 12. It includes 20 men with low- or intermediate-risk prostate cancer. The main goal is to check safety, especially any serious side effects with…

This study is for people with advanced biliary tract cancer whose disease is stable after initial chemotherapy and immunotherapy. It tests whether adding different drugs (lenvatinib, venadaparib, or IL-2) to maintenance immunotherapy can keep the cancer under control longer. Abou…

This study tests whether lecanemab, a drug that clears amyloid plaques in Alzheimer's disease, can also help people with Parkinson's disease who have amyloid buildup in their brains. About 60 adults aged 50-90 with mild cognitive impairment or early dementia will receive lecanema…

This study tests whether giving a single dose of intravenous iron the day after heart surgery can reduce the chance of long-term anemia. About 180 adults with low iron or anemia before surgery will take part. Half will get the iron infusion, half a placebo, and researchers will c…

This study compares two cholesterol-lowering approaches in about 1,950 adults with chronic kidney disease and heart or blood vessel disease. One group gets a moderate statin plus ezetimibe, the other a high-dose statin alone. The goal is to see which strategy better prevents majo…

This study tests two drug combinations for people with a specific type of advanced lung cancer (EGFR-mutant NSCLC). One group gets a new drug (amivantamab) plus a targeted pill (lazertinib) as their first treatment. Another group gets amivantamab plus chemotherapy after their can…

This study tests a precise type of radiation called carbon ion radiotherapy given before surgery for soft tissue sarcoma. The goal is to better control the tumor while reducing side effects and wound healing problems after surgery. About 60 adults with sarcoma that can be removed…

This study tests a new approach for people with end-stage heart failure and permanent atrial fibrillation who are waiting for a heart transplant or a heart pump. Participants will receive a special pacemaker and a procedure to calm the heart's electrical signals, along with an im…

This study tests the drug everolimus in 67 people with certain blood vessel growths or malformations that did not improve with other treatments. The goal is to see if everolimus can shrink these growths or improve symptoms. Participants take the drug by mouth, and doctors monitor…

This study compares two approaches for treating persistent atrial fibrillation (AFib), a common heart rhythm problem. About 406 adults having their first catheter ablation will either receive standard pulmonary vein isolation (PVI) alone or PVI plus ablation of extra triggers fou…

This early-phase study tests a new treatment called AB-201 for people with advanced HER2-positive stomach or gastroesophageal junction cancer that has stopped responding to standard therapies. AB-201 uses specially designed immune cells (CAR-NK cells) to target and kill cancer ce…

This study compares a newer pacing method (left bundle branch area pacing) with the standard approach for cardiac resynchronization therapy in 44 adults who have both permanent atrial fibrillation and heart failure. The goal is to see if the newer method improves the heart's pump…

This study looks at people who had a heart attack and received a stent. It compares different combinations of blood thinners and cholesterol drugs to find the safest and most effective way to prevent future heart problems while reducing side effects like bleeding. About 4,400 adu…

This study tests whether an artificial intelligence tool (SmartECG-AFrisk) can detect atrial fibrillation (AF) earlier than standard care in 1,230 adults with symptoms like palpitations or dizziness but no prior AF diagnosis. Participants are randomly assigned to usual monitoring…

This study checks if a new skin thermometer (XST600) can accurately measure core body temperature compared to a standard device (3M SpotOn). About 117 adults who need temperature monitoring in the hospital will participate. The goal is to see if the new thermometer is a safe and …

This study will test a small, single-lead ECG patch that sticks to the chest and sends heart rhythm data to a central monitoring system. It aims to help doctors spot serious heart rhythm problems like atrial fibrillation or ventricular tachycardia faster in hospitalized patients.…

This study compares apixaban alone versus apixaban plus clopidogrel in 586 adults who recently had a stroke due to atrial fibrillation and hardened brain arteries. Participants take either one or two blood thinners for 30 days. The goal is to see if the combination better prevent…

This study compares two sedative drugs, remimazolam and midazolam, to see which one causes less confusion (delirium) after heart valve surgery in people aged 65 and older. Delirium is a common and serious problem after heart surgery, leading to longer hospital stays and memory is…

This study tests a smartphone app called One.Dr to see if it can reduce the drop in blood pressure that happens when people with orthostatic hypotension stand up. About 86 adults who feel dizzy when standing will be randomly assigned to use the real app or a sham version for 6 we…

This study compares a newer robotic surgery with fewer incisions to the standard laparoscopic surgery for people with early-stage stomach cancer. About 538 adults aged 20 to 80 will be randomly assigned to one of the two procedures. The main goal is to see if the robotic approach…

This study tests whether a surgeon can give a pain-relieving nerve block during knee replacement surgery as effectively as an anesthesiologist using ultrasound. 48 adults having both knees replaced will get one type of block on each knee. The goal is to see if the surgeon's metho…

This study tests whether listening to binaural beats—special sounds that help relax the brain—can reduce the amount of sedative medication needed during a C-section. About 100 women having a planned C-section under spinal anesthesia will either listen to these beats or not. The g…

This study looks at two methods of numbing the knee after total knee replacement: a single injection versus a continuous drip of pain medicine through a small tube. Researchers want to see which provides better pain control over 48 hours. About 78 adults having knee surgery will …

This study will create a registry of 200 adults who have had immediate allergic reactions to drugs, like hives or anaphylaxis. Researchers will analyze blood samples and medical records to understand why these reactions happen and improve diagnosis. The goal is to develop better …

This study tests whether listening to binaural beats (a type of sound therapy) can lower the amount of anxiety medication needed during a C-section done under spinal anesthesia. Researchers will compare two groups of pregnant women: one that listens to binaural beats and one that…

This study compares how much radiation doctors are exposed to during a common heart procedure (PCI) when they access the artery through the left wrist versus the right wrist. About 748 adults scheduled for PCI will take part. The goal is to see if one approach is safer for the do…

This study tests whether an artificial intelligence (AI) tool can help emergency room doctors better interpret heart CT scans for people with chest pain. About 530 adults at intermediate risk for a heart attack will be randomly assigned to have their scans read with or without AI…

This study is a large registry that will collect information from 10,000 adults who undergo exercise echocardiography (a heart ultrasound during exercise) as part of their regular care. The goal is to learn how the heart changes during exercise in people with different types of h…

This study will test a training program where new surgical residents, anesthesia nurses, and operating room nurses practice working together in simulated scenarios. The goal is to see if this team training improves their confidence in teamwork and their readiness to learn togethe…