University Of California, San Diego

This study is testing whether a computer-based brain-training program can improve working memory in people with mild cognitive impairment, an early stage of Alzheimer's disease. 112 participants will complete either the active brain training or a placebo version during twice-week…

This study is testing whether following a specific high-fiber, plant-based Mediterranean diet for two weeks after a colonoscopy can improve gut health and reduce inflammation. Researchers will enroll 30 people with a history of colon polyps to see if the diet helps restore health…

This study tests whether adding the experimental drug cirmtuzumab to standard venetoclax treatment can eliminate the last remaining cancer cells in patients with chronic lymphocytic leukemia (CLL). It involves 5 patients who have been on venetoclax for at least a year but still s…

This early-stage study is testing a new order for giving approved drugs to patients whose chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) has returned or stopped responding to treatment. The goal is to see if giving two drugs (rituximab and methylprednisolo…

This study tests whether giving primary care doctors better tools and training can improve care for women with urinary incontinence (bladder leakage). About 1,600 women and their doctors across Southern California will participate. Researchers will compare offices using the new s…

This study is testing if taking the drug axitinib before surgery can shrink complex kidney tumors, making a kidney-sparing operation possible for patients who otherwise couldn't have it. The goal is to see if this approach is safe and helps surgeons successfully remove tumors whi…

This study aims to improve the quality of care for women with urinary incontinence (bladder leaks) in primary care settings. It will compare two support methods for doctors: one uses electronic specialist advice, and the other uses dedicated nurse practitioners to help manage pat…

This study is testing if combining a meditation-like breathing exercise with a magnetic brain stimulation treatment (rTMS) works better for depression than the stimulation alone. It involves 50 adults with moderate to severe depression who haven't gotten enough relief from antide…

This study is testing a custom-made genetic drug for a single child with a rare, severe brain disorder called TUBB4A-related leukodystrophy. The drug is designed to target the child's specific genetic mutation, with the goal of controlling symptoms like muscle stiffness and impro…

This study is testing whether time-restricted eating (limiting all food intake to a 10-hour window each day) helps obese adults lose weight and improve how their body fat responds to natural weight-loss signals. Researchers will compare this approach to standard nutritional couns…

This study is testing whether combining two types of therapy can help older adults with schizophrenia improve their daily functioning. The program blends cognitive-behavioral social skills training with computerized brain exercises designed to boost thinking skills. Researchers a…

This study aimed to test a new parent training program designed to help children who have both ADHD and weight concerns. The program taught parents strategies to improve their child's planning and self-control skills while promoting healthy habits. Researchers wanted to see if th…

This study is testing if wearing a small electrical ear clip device for six hours each night can safely help reduce extra heartbeats called premature ventricular complexes (PVCs). Sixteen adults with a significant PVC burden will try both a real and a fake version of the device f…

This study is testing a new portable device called LiverScope that could make it easier to diagnose fatty liver disease. Researchers are comparing this new device to standard MRI and ultrasound scans to see if it works just as well. Participants will have one visit where they try…

This study compares two different stool test kits mailed to people's homes to see which one gets more adults aged 45-49 to complete colon cancer screening. Researchers will send either the Cologuard test or the FIT test to 400 participants who aren't up-to-date with their screeni…

This study is testing if a peer counseling program can help people who use drugs check their drugs for dangerous substances and adopt safer habits to prevent overdoses. It will involve 588 adults in San Diego who use opioids or methamphetamine. The goal is to see if this support …

This study is testing a year-long program to help Latina teenagers who aren't very active get more exercise. Researchers will work with 200 teens, half of whom will get a personalized plan with a counseling session, a Fitbit, text reminders, and a special website. The other half …

This study is testing whether a community-led program called 'Close to Home' can prevent sexual violence. It will compare 18 California communities, some running the program and some not, to see if the program changes social attitudes and reduces violence. The research involves a…

This study is testing a 12-week online exercise program designed to prevent falls in older adults. Researchers are enrolling about 92 participants, focusing on those at higher risk of falling and from lower-income backgrounds. The program uses video calls with small-group, person…

This pilot study aims to find out if mailing a Cologuard test kit or a simpler FIT test kit is more effective at getting people to complete colon cancer screening. It involves 100 adults aged 45-49 who are not up-to-date with their screening. Researchers will measure how many peo…

This study is testing whether watching educational videos about common labor experiences during pregnancy can help prevent traumatic stress symptoms after childbirth. Researchers are enrolling 400 first-time mothers to compare those who receive the video education with those who …

This study is testing whether a non-invasive brain stimulation technique can help people with anorexia nervosa. Researchers are using a method called transcranial magnetic stimulation (TMS) to target brain circuits involved in body image and eating behaviors. The goal is to see i…

This study is comparing two ways to control pain after ankle surgery. One method is a single, long-acting numbing shot. The other is a continuous nerve block delivered through a small pump and catheter. The goal is to see if the single shot works as well as the pump at reducing p…

This study is testing whether a purified CBD oral solution can reduce severe behavior problems in children with autism. Forty-two boys aged 7-14 with severe aggression, self-harm, or hyperactivity will receive either CBD or a placebo for 8 weeks, then switch treatments. Researche…

This study is testing if a special, week-long numbing technique can prevent chronic phantom limb pain after a leg amputation. Researchers are comparing a strong, 7-day nerve block to a weaker, 1-day block to see which better reduces long-term pain and opioid use. The goal is to h…

This study is testing a single, 5-minute procedure that freezes nerves near broken ribs to provide pain relief for up to 2-3 months. The goal is to see if this freezing method, called cryoneurolysis, can effectively control pain and reduce the need for opioid painkillers like oxy…

This study is testing a new medical device called RELAY that aims to better control pain after shoulder or foot surgery. The device combines a standard local anesthetic injection with a small electrical current delivered through the same tiny tube, potentially providing pain reli…

This study aimed to test a new device called RELAY for managing pain after knee surgery. The device combines a local anesthetic injection with electrical nerve stimulation, potentially providing pain relief for up to 28 days. The goal was to see if this approach could reduce the …

This study is testing whether a combination treatment works better than medication alone for quickly reducing suicidal thoughts. Researchers are comparing a nasal spray medication (esketamine) plus a brief talk therapy to the nasal spray by itself. They are enrolling adults aged …

This study is testing two different ways to deliver numbing medicine through a small tube placed near nerves after arm or leg surgery. Researchers want to see if a newer method, where the pump gives automatic, adjustable doses, works as well for pain and lasts longer than the sta…

This early-stage study is testing whether cannabidiol (CBD) can help reduce the anxiety people with anorexia often feel around meals. Researchers will give CBD to 40 participants to check for side effects, see how their bodies process it, and measure any changes in eating disorde…

This small pilot study is testing whether inhaling cannabis can quickly stop migraine pain and other symptoms like light sensitivity. Twenty adults with migraines will try three different strengths of cannabis and a placebo during separate attacks to see which works best. The goa…

This small pilot study is testing whether a ketone supplement drink can help people with anorexia or bulimia. Researchers want to see if the drink reduces the urge to binge eat or restrict food, and improves mood and anxiety. Participants will try the drink or a placebo while hav…

This study is testing if temporarily freezing specific nerves near the ribs can provide long-lasting pain relief after breast removal surgery (mastectomy). The goal is to see if this single, non-addictive procedure can reduce both short-term pain and the need for opioid painkille…

This study aims to understand if using cannabis changes the levels of HIV medications in the body and brain, and if it affects mood and thinking. Researchers will observe 120 people who already use cannabis and also give cannabis or a placebo to 40 people to measure immediate eff…

This study aims to find a brain test that can predict which Alzheimer's patients will respond best to the medication memantine. Researchers will measure brain activity after a test dose in 53 patients with mild-to-moderate Alzheimer's. The goal is to match patients with the treat…

This study aims to develop a simpler, cheaper method to study the brain in anorexia nervosa. Researchers are testing if a brainwave recording (EEG) can detect the same brain signals as a complex MRI scan when teens receive unexpected rewards. The goal is to create a practical res…

This study aims to better understand blood pressure changes in the 6 weeks after childbirth. Researchers will give 300 new mothers a special smartwatch that continuously monitors blood pressure to see how patterns differ between low-risk, medium-risk, and high-risk women. The goa…

This study aims to understand how negative emotions like stress or sadness affect the brain's reward system and food choices in people with binge eating disorders and obesity. Researchers will use brain scans (fMRI) to compare brain activity in four groups of adults: those with b…

This study aimed to check if a new type of ureteral stent, placed after kidney stone procedures, causes urine to flow backward from the bladder. Researchers planned to use imaging to grade this backflow in adult patients with kidney stones. The trial was withdrawn before any part…

This study aimed to understand if there is a connection between non-alcoholic fatty liver disease (NAFLD) and active psoriatic disease (skin/joint inflammation). Researchers wanted to see if a medication called Guselkumab, already approved for psoriasis, could also improve fatty …

This study aimed to test a new way to measure what people eat by analyzing tiny natural markers in blood, hair, and fingernails. Researchers wanted to see if these markers were more accurate than traditional food surveys. The goal was to improve diet tracking to help prevent hear…

This study is testing a new team-based strategy to improve how a large children's hospital screens for depression. It involves 40 doctors and staff members. The goal is to make the screening process smoother and faster so children who need help get connected to mental health serv…

This study is testing whether a special type of MRI scan can predict how well treatment will work for men with high-risk prostate cancer. One hundred men who are scheduled to receive standard radiation and hormone therapy will get this advanced scan before, during, and after trea…

This study aims to understand if checking brain function every hour versus every two hours affects sleep quality for patients in the intensive care unit (ICU). Researchers are observing 30 adults who had a procedure to treat a brain aneurysm. They will measure sleep using brain w…