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New combo aims to reduce dangerous side effect in blood cancer treatment

NCT ID NCT04981912

First seen Nov 01, 2025 · Last updated May 25, 2026 · Updated 30 times

Summary

This early-phase study tests whether giving rituximab and high-dose steroids before venetoclax can safely lower the number of cancer cells in people with relapsed or refractory chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). The goal is to reduce the risk of tumor lysis syndrome, a potentially serious side effect from rapid cancer cell breakdown. About 4 adults who have already tried at least one prior treatment will participate, and the approach is considered experimental.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • UCSD Moores Cancer Center

    La Jolla, California, 92093, United States

Conditions

Explore the condition pages connected to this study.