University Of California, San Diego

This early-stage study tests whether adding specially designed viruses (phages) to standard antibiotics can safely treat stubborn lung infections in adults with cystic fibrosis. About 30 participants will receive a 7-day course of both treatments. The main goal is to check safety…

This study tests whether a shorter course of hormone therapy (6 months) combined with radiation works as well as the standard longer course (18 months) for men with high-risk prostate cancer. About 150 participants will receive radiation plus either short or long hormone therapy …

This study looks at whether drugs chosen based on a patient's tumor DNA mutations can delay cancer growth longer than standard treatments. About 280 adults with metastatic or unresectable solid cancers will either receive matched drugs or standard care. Participants visit the cli…

This study tests a drug called seladelpar in 10 adults who have bile duct damage (ischemic cholangiopathy) after a liver transplant. The goal is to see if the drug can lower certain liver enzymes, which would mean less bile duct injury. Participants will take the drug for 26 week…

This study tests whether the antibiotic trimethoprim, taken daily for 3 months, can safely lower folate levels in men starting hormone therapy for advanced prostate cancer. About 50 men will participate. The goal is to see if this approach is safe and might help control the cance…

This study tests a system where doctors get easy-to-read reports from patients' wearable fitness trackers. The goal is to help doctors counsel patients with high blood pressure to increase their physical activity. About 330 patients and their doctors will take part. The study wil…

This study tests whether wearing a continuous ketone monitor alongside a continuous glucose monitor can reduce the risk of a serious side effect (high ketones) from the drug sotagliflozin in people with type 1 diabetes. About 52 adults will take two different doses of the drug wh…

This study tests whether adding mindfulness training to ketamine-assisted therapy helps people with opioid use disorder reduce drug use and cravings. About 88 adults currently on buprenorphine will be randomly assigned to receive either the combined therapy or ketamine with a sup…

This study tests two smartphone tools to help HIV-negative men who have sex with men stick to their daily PrEP medication and reduce methamphetamine use. About 100 participants will use the apps or be placed on a waiting list, and researchers will check if the approach is practic…

This study tests a program called Safe Night Out, which trains bar staff to spot and stop sexual and intimate partner violence. Researchers will compare 25 bars that use the program with 25 that don't, tracking 150 staff and 500 patrons over 18 months. The goal is to see if the p…

This study tests whether a friendly AI chatbot can help new mothers learn about pelvic floor health and feel less lonely after childbirth. About 130 first-time moms will be randomly assigned to either standard care or standard care plus the chatbot for 4 weeks. Researchers will c…

This study tests whether a non-invasive brain training technique called gamma EEG neurofeedback can improve working memory in adults with schizophrenia or schizoaffective disorder. About 104 participants will be randomly assigned to receive either real neurofeedback (learning to …

This pilot study tests whether the nutritional supplement coenzyme Q10 can reduce symptoms and improve quality of life in 20 people affected by the 2023 East Palestine, Ohio train derailment. Participants must have lived within 10 miles of the derailment and have persistent multi…

This study looks at whether a therapeutic ketogenic diet (high-fat, low-carb) can help reduce eating disorder symptoms like fear of weight gain and body image issues in people with anorexia nervosa. About 60 participants aged 16 to 45 in a partial hospital program will either fol…

This study will test a psychological treatment for chronic pain that is adapted to the culture of American Indian and Alaska Native peoples. About 30 adults with chronic pain will take part to see if the program is acceptable and practical. The goal is to gather information neede…

This study looks at how to best screen for and manage HPV in women living with HIV, who are at higher risk for cervical cancer. Researchers will test a new method that identifies specific HPV types and measures viral load. The goal is to see if this approach is practical for a la…

This study will test two new services at a large Chicago health clinic: routine substance use screening for all patients, and a program that asks people to refer friends or partners who might need HIV or addiction support. The goal is to see if these methods help more people lear…