Thomas Jefferson University

This study tests whether a continuous glucose monitor (CGM) helps pregnant women with type 2 diabetes track their blood sugar better than traditional finger-stick testing. Seventy participants will be randomly assigned to use either a CGM or a glucometer from enrollment until del…

This phase 2 trial tests a two-step stem cell transplant using lower doses of radiation and chemotherapy before the transplant. The goal is to reduce treatment-related deaths in people with various blood cancers like leukemia, lymphoma, and myeloma. About 63 participants will rec…

This early-phase trial tests two different drug combinations for people whose acute myeloid leukemia (AML) has returned or not responded to prior treatment. In Part 1, participants receive tazemetostat plus a standard chemotherapy called CPX-351. In Part 2, they get palbociclib b…

This study tests a drug called tebentafusp combined with treatments directed at the liver (like embolization or chemo-embolization) for people with a rare eye cancer (uveal melanoma) that has spread to the liver. About 109 adults with a specific immune type (HLA-A*0201) will part…

This study tests two non-invasive techniques to improve breathing in people with chronic spinal cord injury. Participants will receive spinal cord stimulation and breathe special air mixtures to strengthen breathing muscles. The study involves 20 adults with incomplete spinal cor…

This study tests whether high-dose radiotherapy can provide lasting relief for people with moderate to severe hidradenitis suppurativa (HS) that hasn't improved with standard treatments. Ten adults with HS in both armpits will receive radiation to one armpit only, while the other…

This early-phase trial tests a two-step vaccine strategy in adults with advanced colorectal or small bowel cancer that has stopped responding to standard treatments. Participants first receive one vaccine injection, followed by two doses of a second vaccine four weeks apart. The …

This study tests whether giving iron through a vein (IV) early in the second trimester works better than iron pills for treating anemia in pregnancy. About 80 pregnant women with mild iron deficiency will be randomly assigned to one of the two treatments. The goal is to see which…

This study tests whether placing a stitch (cerclage) in the cervix can lower the chance of preterm birth in pregnant people with a short cervix (≤25mm) detected between 24-26 weeks. About 329 participants will be randomly assigned to receive the stitch or standard care. The main …

This study tests a drug called tebentafusp in 19 people with a rare eye cancer (uveal melanoma) that is too large to remove without taking the whole eye. The goal is to see if the drug can shrink the tumor by at least 20% so that less invasive surgery might be possible. Participa…

This early-phase trial tests whether using ultrasound and microbubbles can help the immunotherapy drug pembrolizumab reach tumors better in people with recurrent or metastatic head and neck cancer. Only 6 participants will be enrolled to see if the approach is feasible and safe. …

This study tests a new approach to collecting stem cells for people with multiple myeloma, Hodgkin lymphoma, or non-Hodgkin lymphoma who need a stem cell transplant. The goal is to see if using a standard drug alone, and adding another drug only when needed, can collect enough st…

This study looks at whether cutting calories while getting focused radiation (SABR) before surgery can shrink breast tumors more than radiation alone. About 80 adults with early-stage breast cancer will be randomly assigned to one of two groups. The goal is to see if the diet hel…

This study tests whether advanced genetic sequencing (whole exome and whole genome) can find the root cause of nonimmune hydrops fetalis, a serious condition where fluid builds up in a fetus or newborn. Standard tests often miss single-gene disorders. Researchers will enroll 55 f…

This study is testing a new way to detect prostate cancer by looking at cells in a urine sample using a special optical imaging method. Researchers will collect urine from 675 men aged 50-75, including those with and without prostate cancer, to see how accurate the test is. If it…

This study explores whether women can accurately collect their own samples for HPV testing, which could make cervical cancer screening easier and more accessible. The research focuses on minority women who are often under-screened, using community health workers to help with the …

This study tests whether a self-help version of Acceptance and Commitment Therapy (ACT), delivered via smartphone, can reduce anxiety and depression in adults with cystic fibrosis. About 60 participants will use the toolkit and report their symptoms. The goal is to improve mental…

This study looks at whether adding cognitive behavioral therapy (CBT) to standard education helps people who take opioids for chronic pain taper off them before spine surgery. About 45 adults scheduled for major spine surgery at least four weeks ahead will be split into two group…

This study looks at whether placing a small tube (stent) in the urinary tract after bladder removal surgery affects recovery. About 70 adults with bladder or pelvic cancers will be randomly assigned to get a stent or not. The main goal is to see if avoiding stents lowers the risk…

This study tests whether giving blood transfusions at home is practical and acceptable for cancer patients who need regular transfusions. About 30 adults with blood cancers or bone marrow failure will receive 1-5 blood product units at home. Researchers will track how often trans…

This study tests whether taking two common pain relievers (acetaminophen and NSAIDs) at different times works better than taking them together after a cesarean delivery. About 825 women who have a C-section will be randomly assigned to one of the two schedules. The goal is to fin…

This study tests whether a 14-day mobile diary is a practical way to measure daily stress and thinking (cognitive) changes in breast cancer survivors. Researchers will enroll 30 racially diverse women aged 40 and older who are at least five years past diagnosis. Participants comp…

This study looks at whether PET/CT scans can detect heart damage caused by radiation therapy in people with lung or esophageal cancer. About 20 participants will get special heart scans before, during, and after their radiation treatment. The goal is to see if the scans can pick …

This study looks at why cancer patients who have needs like help with transportation, food, or housing choose not to accept support services. Researchers will survey 500 adults and interview a smaller group to understand their reasons. The goal is to improve how hospitals offer h…

This study tests whether contrast-enhanced ultrasound (CEUS) can more accurately show if liver cancer (HCC) has been killed by a treatment called radioembolization (TARE). Standard CT or MRI scans often take months to give a clear answer, which can delay needed retreatment. Resea…

This study looks at how to help cancer patients from low-income and low-literacy backgrounds take their oral chemotherapy pills correctly. Researchers will test different support strategies to see which ones work best. The goal is to reduce missed doses and improve overall care f…

This study watches 20 adults in cardiogenic shock who need a temporary heart pump (IABC). Researchers want to see if the stiffness of the arteries changes how well the pump works. They will measure blood flow and other vital signs before, during, and after the pump is used. The g…

This study is a worldwide registry that collects information from people with a rare spinal blood vessel condition called spinal dural arteriovenous fistula. The goal is to gather enough data to better understand the disease and improve future treatments. Participants must have b…

This study looks at whether a network of peer genetic coaches can help African American men with metastatic prostate cancer overcome barriers to genetic testing. The coaches will provide support and navigation to increase awareness and access. The study involves 30 participants a…

This study explores whether virtual reality and 3D models can help surgeons plan head and neck cancer operations more accurately. About 160 adults with head and neck cancer will take part. The goal is to see if this technology reduces the chance of leftover cancer cells and impro…

This study collects leftover tumor tissue and a one-time blood sample from 200 adults with breast cancer or precancerous breast conditions. Researchers will analyze the samples to identify cancer biomarkers and understand how genes interact with tumors. Participants do not receiv…

This early study tests whether contrast-enhanced ultrasound (CEUS) can help doctors see how soft tissue sarcoma responds to radiation therapy given before surgery. Ten adults with sarcoma will get CEUS scans at three points during treatment. The goal is to see if combining ultras…

This study looks at whether having a trained peer navigator—someone who guides patients through the process—helps African American men with advanced prostate cancer better understand and complete genetic testing. Genetic testing is important for treatment decisions, but many pati…

This study looks at how social factors like stress and support relate to inflammation in women newly diagnosed with breast cancer. About 200 participants will fill out questionnaires and give one blood sample. The goal is to understand these links, not to provide treatment.

This study looks at two different ways surgeons cut blood vessels during lung cancer surgery. The goal is to see if tying off the vein first (instead of the artery) reduces the amount of tumor DNA released into the bloodstream. About 100 adults with early-stage lung cancer will h…