Thomas Jefferson University

After lung surgery, some patients have a persistent air leak that requires a chest tube for days. This study tests whether injecting a sugar water solution (dextrose) through the tube can seal the leak faster than standard drainage alone. About 80 adults with a stubborn air leak …

This study tests a new two-drug combination (pacritinib plus azacitidine) for people with moderate to very high risk myelodysplastic syndrome (MDS), a bone marrow disorder. The first part finds the safest dose of pacritinib, and the second part checks how well the combination wor…

This study tests a new way to treat infected knee replacements. About 100 adults having surgery for an infected knee will be randomly assigned to receive either standard care or standard care plus an extra treatment. The extra treatment involves injecting antibiotics along with s…

This study compares a special ultrasound (mp-US) with contrast dye to standard MRI for finding prostate cancer. About 300 men scheduled for a biopsy will get both scans to see if the ultrasound can guide biopsies just as well as MRI. The goal is to offer a simpler, cheaper option…

This study looks at whether giving the drug ketamine earlier, along with standard midazolam, can stop seizures faster in adults with refractory status epilepticus (seizures that don't stop with usual medicines). The trial will involve 50 adults who have not responded to first- an…

This study tests if a personalized physical therapy program helps people recover better after ventral hernia repair. About 100 adults aged 18-75 will be randomly assigned to either standard care or a tailored 10-week PT plan. Researchers will measure pain, quality of life, compli…

This study tests a program called BEST4Baby, which uses trained peer counselors and a mobile health app to support new mothers in India with breastfeeding. About 336 pregnant women will be split into two groups: one gets the extra support, the other gets usual care. Researchers w…

This study tests a program called Improving Dementia Care (IDC) to help primary care doctors identify dementia in patients who have memory concerns but no prior diagnosis. About 80 adults with mild cognitive issues will take part. The goal is to see if the program leads to more d…