Thomas Jefferson University

This study tests whether giving immunotherapy drugs (cemiplimab alone or with fianlimab) before surgery can shrink advanced basal cell skin cancers on the head and neck. About 70 adults with tumors that are hard to remove without major surgery will receive 2 to 6 infusions before…

This study tests a procedure called chemoembolization for people with uveal melanoma (an eye cancer) that has spread to the liver. Doctors inject a chemotherapy drug (BCNU) mixed with an oily substance directly into the liver's blood supply, then block the artery with a sponge-li…

This early-phase trial tests whether giving higher doses of radiation, guided by special PET/MRI scans, is safe for people with high-risk meningiomas (aggressive or recurrent brain tumors). About 24 adults will receive one of four radiation dose levels to find the highest dose th…

This early-phase study tested a combination of enzalutamide (a hormone-blocking drug), radiation therapy, and standard hormone therapy in 25 men with intermediate or high-risk prostate cancer. The main goal was to check for side effects and find the best way to give the treatment…

This early-phase study tests the safety of combining three drugs—venetoclax, lenalidomide, and rituximab—in people with follicular or marginal zone lymphoma that has returned or not responded to prior treatment. The goal is to find the best dose and see if the combination is safe…

This study aimed to compare two different needles used to take tissue samples from solid masses in the pancreas and digestive tract. The goal was to see which needle provides a more accurate diagnosis. The study was planned for adults needing this procedure, but it was withdrawn …

This study tests a wearable device that listens to breathing sounds to detect and predict when opioids cause dangerously slow or stopped breathing. About 120 adults recovering from surgery will wear the device, and its accuracy will be compared to standard monitors. The goal is t…

This study tests whether a special ultrasound, using tiny gas-filled bubbles, can spot prostate cancer without a needle biopsy. About 70 men who are already scheduled for prostate removal will get this ultrasound before surgery. The goal is to see if the bubbles make cancer show …

This study compares three pain relief methods for people aged 55 and older with three or more broken ribs on one side. Participants will receive either a nerve block with a numbing medicine, a lidocaine drip, or standard pain care including opioids. The goal is to see which appro…

This study tests whether a device called transcutaneous auricular vagus nerve stimulation (TaVNS) can reduce anxiety and distress in healthcare workers. About 90 participants will use the earbud-like device, and some will also have brain scans to see how it affects brain activity…

This study looks at whether N-acetyl cysteine (NAC), an antioxidant supplement, can improve brain function in people with multiple sclerosis (MS). Researchers will use special PET-MRI scans to measure brain activity and inflammation. About 55 adults with MS who are not planning t…

This study looks at whether taking ketone or hawthorn supplements for 8 weeks can improve exercise ability and heart function in people with congestive heart failure. About 45 adults with mild to moderate heart failure will be randomly assigned to receive one of the supplements o…

This study tests whether electrical and magnetic stimulation can help people with chronic spinal cord injury move better and feel less stiffness. Ten participants will try different stimulation methods to see which works best. The goal is to improve walking, arm use, and daily li…

This study looks at whether a web-based virtual genetics board helps doctors discuss and manage prostate cancer genetics. About 118 healthcare providers, including oncologists and genetic counselors, will use the board and then give feedback through surveys and interviews. The go…

This study looks at what helps or hinders people from getting screened for colorectal cancer, focusing on African American, Latinx, and Chinese communities. Researchers will conduct interviews and focus groups to understand cultural beliefs and knowledge gaps. The goal is to crea…

This study was designed to track sleep quality in people with head and neck cancer undergoing surgery. Researchers planned to measure factors like time to fall asleep and nighttime awakenings to understand how treatment impacts sleep. The study was withdrawn before enrolling any …