New genetic sleuthing could solve mysterious fetal swelling cases
NCT ID NCT03911531
First seen Nov 01, 2025 · Last updated Jun 23, 2026 · Updated 37 times
Summary
This study tests whether advanced genetic sequencing (whole exome and whole genome) can find the root cause of nonimmune hydrops fetalis, a serious condition where fluid builds up in a fetus or newborn. Standard tests often miss single-gene disorders. Researchers will enroll 55 families where standard genetic tests are negative, aiming to improve diagnosis and help parents understand risks for future pregnancies.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Locations
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Thomas Jefferson University
RECRUITINGPhiladelphia, Pennsylvania, 19107, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
What this could lead to
If successful, this could help identify hidden genetic causes of hydrops, giving families a diagnosis and better guidance for future pregnancies.
What could go wrong
This is a small, early-stage study (55 participants) focused on diagnosis, not treatment. It may not find new causes or benefit all families.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.