Thomas Jefferson University

This study tests a two-step approach to bone marrow transplant using lower doses of radiation and chemotherapy before the transplant. The goal is to see if this gentler method reduces the number of patients who die from treatment side effects. The study includes adults with vario…

This study tests a drug called tebentafusp in people with a rare eye cancer (uveal melanoma) that is too large to remove with standard surgery. The goal is to see if the drug can shrink the tumor enough to allow less invasive treatment. About 19 participants will receive the drug…

This early-phase study tests an experimental daily pill, VK-2019, in 30 adults with a rare type of lymphoma (EBV-positive DLBCL) that has come back or not responded to at least two prior treatments. The main goal is to find the safest dose and see if the drug can control the canc…

This study tests a drug called tebentafusp combined with procedures that target liver tumors (like embolization or chemo-embolization) in people with a specific type of eye cancer that has spread to the liver. The goal is to see if the combination is safe and helps control the ca…

This study looks at whether reducing calories while getting focused radiation (SABR) before surgery can shrink breast tumors more than radiation alone. About 80 adults with early-stage breast cancer will be randomly assigned to one of two groups. The goal is to see if the combina…

This early-phase trial tests whether using ultrasound waves to create tiny bubbles in tumors can help the immunotherapy drug pembrolizumab work better. The study enrolls 6 adults with recurrent or metastatic head and neck cancer whose tumors are accessible by ultrasound. The main…

This early-phase study is testing two different drug combinations for people whose acute myeloid leukemia (AML) has come back or not responded to prior treatment. In one part, patients receive tazemetostat plus standard chemotherapy (CPX-351); in the other, they get palbociclib b…

This study aims to see if a new urine test can accurately detect prostate cancer. Researchers will collect urine samples from 675 men and use a special imaging method to look for cancer cells. The goal is to develop a non-invasive way to diagnose prostate cancer, potentially redu…

This study looks at whether women can accurately collect their own samples to test for HPV, the virus that can cause cervical cancer. Researchers are comparing two different self-collection kits to the standard Pap smear done in a clinic. The goal is to make cervical cancer scree…

This study looks at whether a special type of ultrasound (contrast-enhanced ultrasound) can better show if liver cancer treatment (radioembolization) is working. Standard CT or MRI scans can take months to give clear results, which may delay further treatment. The study will enro…

This study looks at whether adding cognitive behavioral therapy (CBT) to standard education helps people who take opioids for chronic pain reduce their dose before spine surgery. About 45 adults scheduled for major spine surgery at least four weeks ahead will be split into two gr…

This study looks at whether placing a small tube (stent) in the ureter during bladder removal surgery affects recovery. About 70 adults with bladder or pelvic cancer will be randomly assigned to get a stent or not. The main goal is to see if stents reduce the risk of urinary trac…

This study is testing whether giving blood transfusions at home is practical and okay for cancer patients who need transfusions often. About 30 adults with blood cancers or bone marrow problems will receive 1-5 units of blood products at home. Researchers will track how often tra…

This study looks at the best way to schedule common pain relievers (acetaminophen and NSAIDs) after a cesarean delivery. About 825 women who have a C-section will be randomly assigned to take the medicines at the same time or at different times. The goal is to see which schedule …

This study tests whether a self-help smartphone toolkit based on Acceptance and Commitment Therapy can reduce anxiety and depression in adults with cystic fibrosis. About 60 participants will use the toolkit on their phones and report changes in mood and psychological flexibility…

This early study tests if a special ultrasound with contrast dye can help doctors see how soft tissue sarcoma responds to radiation therapy before surgery. Ten adults with sarcoma will get three ultrasounds during their treatment. The goal is to see if this imaging method can pre…

This study tests whether a 14-day mobile diary is a practical way to measure daily stress and thinking skills in breast cancer survivors from diverse backgrounds. Researchers will enroll 30 women aged 40 and older who are at least five years past their diagnosis. Participants wil…

This study collects leftover tumor tissue and a one-time blood sample from 200 adults with breast cancer or precancerous breast conditions. Researchers will analyze the samples to identify biomarkers and gene patterns linked to the cancer. Participants do not receive any treatmen…

This study looks at two standard ways to remove lung cancer in early-stage patients. The goal is to see if tying off the vein before the artery during surgery reduces the amount of tumor DNA released into the bloodstream. About 100 adults with stage I-III non-small cell lung canc…

This study looks at why cancer patients who have needs like help with food, housing, or transportation choose not to accept support services. About 500 adult cancer patients will fill out a survey and some will join a video interview to share their thoughts. The goal is to learn …

This study aims to find the genetic causes of nonimmune hydrops fetalis, a serious condition where fluid builds up abnormally in a fetus or newborn. Researchers will use whole exome and whole genome sequencing on samples from 55 families when standard tests are negative. The goal…

This study looks at how social factors like stress and support might be linked to inflammation in women newly diagnosed with breast cancer. About 200 participants will fill out questionnaires and give one blood sample. The goal is to understand these connections, not to test a tr…

This study is for adults in cardiogenic shock who need a temporary heart pump called an intra-aortic balloon pump. Researchers want to see if the stiffness of a person's arteries affects how well the pump works. They will measure blood flow and other vital signs before and after …