The University Of Texas Health Science Center At San Antonio

This study is testing whether the medication dupilumab can reduce allergy and asthma symptoms triggered by house dust mites. Researchers will expose 88 adults with dust mite allergies to controlled amounts of allergens in a special chamber, then give them either dupilumab or a pl…

This study is testing whether applying a special gel called enamel matrix derivatives (EMD) during dental implant surgery creates thicker gum tissue around the implants. Researchers will compare results between patients who receive the gel and those who don't. The goal is to see …

This study is testing a new drug called sacituzumab govitecan for adults whose aggressive brain cancer (glioblastoma) has returned after initial treatment. The drug is designed to target cancer cells that have high levels of a specific protein. Researchers will give the drug to a…

This study is checking if the weight-loss drug tirzepatide causes older adults to lose too much muscle along with fat, which could lead to weakness. Researchers will give 20 obese adults over age 50 tirzepatide for six months and measure their muscle mass, strength, and walking a…

This early-stage trial is testing whether adding an experimental drug called avasopasem to standard breast cancer therapy is safe and might help when the initial treatment stops working. The study will enroll about 35 women with metastatic, hormone receptor-positive breast cancer…

This small, early-stage study is testing whether a ketone supplement drink can improve heart function in people who have both type 2 diabetes and a specific type of heart failure. Researchers will give 10 participants the supplement and use heart scans and blood tests to see if i…

This study is testing a non-invasive brain stimulation treatment called IR-TMS to see if it can help people with alcohol use disorder reduce their drinking and cravings. Participants receive multiple magnetic stimulation sessions targeting specific brain areas, along with brain s…

This early-stage study aims to find safe and effective doses of two drugs, rapamycin and everolimus, for healthy adults aged 65-90. Researchers want to see if these drugs can safely reduce a specific cellular activity linked to aging to levels seen in young, healthy people. The s…

This study is testing a new therapy designed specifically for military veterans and service members who have both post-traumatic stress disorder (PTSD) and a traumatic brain injury. The treatment involves individual counseling sessions that focus on managing PTSD symptoms without…

This study aims to find out which of two different two-drug combinations works better for controlling blood sugar in people recently diagnosed with type 2 diabetes. It will compare a newer combination (pioglitazone + tirzepatide) against a standard one (metformin + sitagliptin) i…

This study aims to help veterans with PTSD who aren't improving with their first treatment. Researchers will test whether switching to a different therapy approach or using text message reminders for homework assignments works better. The goal is to find the right treatment combi…

This study is testing if adding a specific neck injection, called a stellate ganglion block, to an intensive two-week therapy program works better for reducing PTSD symptoms than the therapy program alone. It will involve 140 active duty or retired military service members diagno…

This study is testing if using a high-magnification digital microscope during gum surgery leads to better healing than the current standard tool, magnifying loupes. Researchers will compare healing in 25 adults who need surgery for gum disease. Each participant will have one inci…

This study is testing whether a combination of two immunotherapy drugs (tremelimumab and durvalumab) is safe and effective for people with advanced liver cancer who also have moderately impaired liver function, known as Child-Pugh B cirrhosis. It focuses on including patients fro…

This study is testing whether a drug called rapamycin, taken daily for a year, is safe and might help slow down memory and thinking problems in older adults with early-stage Alzheimer's disease or mild cognitive impairment. Researchers will enroll 40 participants to measure chang…

This study compares two different bone graft materials used after tooth extraction to help preserve jawbone for future dental implants. Researchers will measure how much new bone forms in the tooth socket after about 16 weeks of healing. The study involves 44 adults who need a si…

This study aims to find affordable ways to stop prediabetes from progressing to full diabetes and reduce heart disease risk in Hispanic adults. Researchers will test four different 6-month drug combinations, including some common diabetes medications, alongside nutritional counse…

This study is testing a special training program designed to help soldiers build mental toughness and better handle stress. It will involve 600 soldiers from a specialized Army unit at Fort Hood. The program teaches skills for managing difficult thoughts and emotions, aiming to i…

This study is testing if light leg exercises, done while wearing tight cuffs that reduce blood flow, can help improve balance, walking, and strength in people with Parkinson's disease. Researchers will compare this approach to the same exercises without the cuffs. The goal is to …

This study is testing whether a type of talk therapy, delivered either in-person or via video call, can reduce the severity and impact of chronic headaches that start after a head injury. It will involve 525 military service members and veterans at seven medical centers across th…

This study aims to find the best talk therapy for insomnia in active-duty military members who have sleep problems and other lasting symptoms after a mild brain injury. Researchers will compare two different therapy programs—one with six sessions and one with four sessions—to see…

This study is testing whether taking amino acid supplements during dialysis treatments can help reduce severe fatigue and improve strength and thinking skills in people with kidney failure. Researchers will compare two different supplement formulas in about 28 patients who receiv…

This study is testing whether using the Calm meditation app for 10 minutes a day can help people with blood cancers who have trouble sleeping. Researchers will enroll 276 patients to see if the app improves sleep quality, reduces fatigue and anxiety, and lowers body inflammation …

This study aims to find out which of two existing medications works better for reducing distressing hallucinations and delusions in people with Parkinson's disease or Lewy body dementia. It will compare pimavanserin and quetiapine in about 94 patients who need to start treatment …

This study is testing whether sitting in a special bathtub that uses low-frequency ultrasound waves can help older adults age more healthily. Twenty participants aged 70 and older will either sit in the ultrasound bath or a regular bath three times a week for eight weeks. Researc…

This small study is testing whether a daily, at-home brain stimulation treatment is safe and practical for people with Huntington's disease. Researchers want to see if this non-invasive therapy can help improve thinking skills and mood-related symptoms. Participants will use a de…

This study is testing whether a home-based brain stimulation device can help improve mood, anxiety, and apathy in people with Alzheimer's disease. Researchers are enrolling 24 older adults with Alzheimer's and their caregivers to use the device at home for 30-minute sessions. The…

This study is testing special listening exercises to help people with mild brain injuries hear better. Many people struggle to understand speech in noisy places or locate where sounds are coming from after such injuries. Researchers want to see if computer-based hearing training …

This study aims to discover new genetic causes of rare tumors called pheochromocytomas and paragangliomas. Researchers will analyze DNA from up to 2,000 patients and family members to find genes linked to these tumors. The goal is to improve genetic testing and help guide screeni…

This study aims to understand why gastric bypass surgery helps control blood sugar and promotes weight loss. Researchers will measure gut hormones in 80 people, including those who have had the surgery and some who experience low blood sugar afterward. The goal is to learn how th…

This study aims to understand how the hormone glucagon controls blood sugar in people who have had weight-loss surgery compared to those who haven't. Researchers will give participants an experimental drug that blocks glucagon's effects and measure their blood sugar response to m…

This study aims to understand how gastric bypass surgery affects the body's insulin production and blood sugar control. Researchers are recruiting people who have had the surgery—some with and some without low blood sugar problems—as well as healthy people who haven't had surgery…

This study aims to better understand how liver cancer affects older adults and how they respond to treatments. Researchers will observe 84 participants with advanced liver cancer, focusing on those aged 65 and older. The goal is to identify treatment patterns and side effects to …

This study aims to understand how adding two specific fatty acids (DHA and ARA) to the diet of very premature infants affects their body's internal processes. Researchers will enroll 328 babies born very early and measure changes in blood fats and other biological markers related…

This study aims to understand how the diabetes drug pioglitazone affects energy production inside liver cells in people with Type 2 diabetes and fatty liver disease (NAFLD or NASH). Researchers will measure chemical processes in the liver before and after 16 weeks of treatment. T…

This early-phase study aims to understand how a common diabetes medication (empagliflozin) affects muscle energy production and heart function in people who have both type 2 diabetes and heart failure. Researchers will measure changes in muscle chemicals and heart performance ove…

This research center aims to understand and eventually treat chromosome 18 abnormalities by collecting detailed medical information over time. The study will enroll up to 4,000 individuals with these genetic conditions and their families. Researchers will perform various tests an…

This study aims to see if 3D x-rays can help doctors determine when dental implants are ready to be placed after sinus surgery. Researchers will take 3D x-rays right after surgery and again six months later to measure bone changes. The study involves 25 adults who need sinus surg…

This research study aims to understand how middle-aged men and women's muscles recover after a period of not being used. Healthy participants aged 50-65 will have one leg immobilized for a week, followed by a week of rehabilitation exercise. Researchers will measure muscle change…

This study is looking at how well 'smart' medication pumps work when they are connected to a patient's electronic health record in eight adult intensive care units. Researchers will survey and interview nurses, watch them use the pumps in practice, and review past patient records…

This early-stage study aims to understand how two common type 2 diabetes medications, empagliflozin and pioglitazone, interact in the body. Researchers will measure how they affect the body's production of sugar, fat breakdown, and ketones in 64 participants. The goal is to gathe…

This study aims to understand how trauma therapy helps teens with PTSD by looking at brain changes. Researchers will scan the brains of 180 teens before and after each phase of therapy to see which parts of the brain change during treatment. The goal is to learn how therapy works…

This study aims to understand how two common weight-loss surgeries—gastric bypass and sleeve gastrectomy—affect the body's blood sugar control after eating. Researchers will compare 200 participants, including people who have had surgery, those with low blood sugar after surgery,…