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Can a neck injection boost PTSD therapy? new trial aims to find out.

NCT ID NCT05889741

Symptom relief Sponsor: The University of Texas Health Science Center at San Antonio Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tests whether a one-time injection of a local anesthetic into a nerve bundle in the neck (stellate ganglion block) can improve the effects of a type of talk therapy called prolonged exposure for PTSD. The trial involves 140 current or retired military members with PTSD. Half receive the real injection and half receive a placebo (saline) injection, both alongside ten 90-minute therapy sessions. The goal is to see if the combination leads to greater reductions in PTSD symptoms.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Ropivacaine injection (local anesthetic)
What this could lead to
If it works, this could offer a way to boost the effects of talk therapy for PTSD, potentially reducing symptoms faster.
What could go wrong
This is an early Phase 2 trial with only 140 participants. The nerve block may not provide added benefit over the sham injection, and there are risks like injection site pain or temporary nerve issues.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 140 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2024

Expected to finish

Aug 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Active duty and retired military service members ages 18-65 years 2. PTSD diagnosis as assessed by Clinician-Administered Posttraumatic Stress Scale 3. Able to speak and read English (due to standardization of outcome measures) 4. Defense Enrollment Eligibility Reporting System (DEERS)-eligible to receive care at a military treatment facility (MTF) where the stellate ganglion block will be placed. Exclusion Criteria: 1. Current suicidal ideation severe enough to warrant immediate attention (as determined by the Depressive Symptoms Index - Suicidality Subscale and the Self-Injurious Thoughts and Behaviors Interview short form) and corroborated by a clinical risk assessment by a credentialed provider. 2. Current manic episode or psychotic symptoms requiring immediate stabilization or hospitalization (as determined by clinical judgment) 3. Symptoms of moderate to severe substance use (to include alcohol) warranting immediate intervention based on clinical judgment. 4. Other psychiatric disorders severe enough to warrant designation as the primary disorder as determined by clinician judgment 5. Pregnancy or breastfeeding 6. Current anticoagulant use 7. History of bleeding disorder 8. Infection or mass at injection site 9. Myocardial infarction within 6 months of procedure 10. Pathologic bradycardia or irregularities of heart rate or rhythm 11. Symptomatic hypotension 12. Phrenic or laryngeal nerve palsy 13. History of glaucoma 14. Uncontrolled seizure disorder 15. History of allergy to local anesthetics 16. Current use of Class III antiarrhythmics

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Conditions

The condition(s) this trial relates to.

post-traumatic stress disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Stress disorders, post-traumatic

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Carl R. Darnall Army Medical Center

    RECRUITING

    Fort Hood, Texas, 76544, United States

  • University of Texas Health Science Center at San Antonio

    RECRUITING

    San Antonio, Texas, 78229, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.