The University Of Hong Kong

This study tests whether giving pembrolizumab (an immunotherapy) with chemotherapy before surgery can eliminate all cancer cells in people whose nasopharyngeal cancer has come back. After surgery, patients continue pembrolizumab for a while to prevent return. The goal is a cure, …

This study tests a volunteer-led lifestyle program for older adults (60+) with sarcopenia, a condition causing muscle loss and weakness. The program includes workshops on nutrition and exercise, supported by nurses and trained volunteers. Researchers will measure changes in muscl…

This study tests whether a smart chatbot can help adults quit smoking as effectively as human support. About 1,000 smokers in Hong Kong will use a WhatsApp chatbot for 12 weeks, receiving personalized advice and encouragement. The goal is to see if the chatbot can boost quit rate…

This early-stage study tests whether a probiotic supplement containing Bifidobacterium can help lower blood pressure in 30 middle-aged Chinese adults with untreated hypertension. Participants will take the probiotic for 12 weeks, and researchers will measure changes in blood pres…

This study tests whether dapagliflozin, a drug already approved for diabetes and heart failure, can improve exercise ability and heart function in people who have had the Fontan procedure. About 30 participants aged 12 and older will take the drug daily for 3 months. The goal is …

This study tests whether adding asciminib to standard therapy after a stem cell transplant can help prevent leukemia from returning in people with certain types of blood cancer (Ph+ B-ALL or blastic phase CML). About 45 adults will be randomly assigned to receive either the stand…

This study tests a traditional Chinese medicine called Yulinzhu in 60 women aged 18-40 with diminished ovarian reserve (low egg supply). Participants take the herbal therapy for 12 weeks, and researchers measure changes in hormone levels and egg count. The goal is to see if the t…

This study tests whether taking folic acid (vitamin B9) daily for 90 days can lower the risk of death within one year for adults with acute kidney injury caused by infections. About 382 participants will either receive folic acid plus standard care or standard care alone. Researc…

This study tests whether taking capsules containing healthy donor stool (fecal transplant) can help clear a dangerous, antibiotic-resistant bacteria called CRE from the gut. About 80 hospitalized adults with CRE will receive either the capsules or a placebo. The goal is to see if…

This study is testing whether a blood test that looks for genetic changes (ctDNA mutations and methylation) can help detect lung cancer early in people who have suspicious lung nodules found on CT scans. Researchers will collect blood samples from 200 participants in Hong Kong an…

This study tests whether a structured exercise program, combined with an AI chatbot and incentives, can prevent osteoporosis and sarcopenia in adults aged 40-60. Over 8,300 participants will be randomly assigned to either the active program or standard advice. The trial will trac…

This study will test whether low-dose CT scans can help find lung cancer early and save lives in heavy smokers aged 50 to 79. About 15,000 people in Hong Kong will take part, with half getting regular scans and half getting usual care. The goal is to see if screening reduces deat…

This pilot study tests a new program for young adults (25 or under) in Hong Kong who recently quit smoking. The program combines personalized counseling with an AI chatbot that sends supportive messages for 30 days. Researchers want to see if this approach is practical and accept…

This study tests if a type of talking therapy called Cognitive Behavioral Therapy for Insomnia (CBTi) can improve sleep and reduce mental distress in young people aged 12 to 24 in Hong Kong. Participants have moderate mental health concerns and trouble sleeping. They will attend …

This study compares three sizes of small chest tubes (8, 12, and 14 French) for talc pleurodesis in people with malignant pleural effusion—fluid buildup caused by cancer. The goal is to see if the smallest tubes work as well as slightly larger ones while causing less pain. Sixty …

This study tests whether an AI-powered app can replace in-person physiotherapy for knee osteoarthritis. 176 adults aged 50+ with knee pain will either follow exercise videos with real-time feedback from the app or attend traditional physiotherapy sessions. The goal is to see if t…

This small pilot study will test whether an 8-week group mindfulness program can reduce stress, anxiety, depression, and insomnia in parents caring for children with autism or ADHD. Thirty Chinese caregivers will attend weekly sessions and complete surveys before and after the pr…

This study tests whether a non-invasive brain stimulation technique called rTMS can improve movement and balance in children with cerebellar ataxia, a condition that causes coordination problems. Twenty children aged 4 to 18 will receive either real or sham (fake) rTMS to see if …

This study tests a brief mindfulness-based lifestyle program for caregivers of people with neurodegenerative disorders like Alzheimer's or Parkinson's. Many caregivers are not physically active, raising their risk for heart disease. The program combines in-person group sessions w…

This study tests a 12-week program called EXCITE-PAC for family members caring for someone with dementia. The program combines counseling, group meetings, and phone support to help caregivers find more meaning and positivity in their role. Researchers will measure changes in care…

This study tests a special dental glue (adhesive) to see if it can reduce tooth sensitivity. 142 adults with sensitive teeth will get one application of either the new glue or a standard glue. Their pain levels will be checked right after and again at 1, 3, and 6 months.

This early-phase study tests whether giving a weight-loss medication (a GLP-1 drug) to obese patients before total knee replacement surgery can reduce pain and improve recovery. About 54 adults aged 40-80 with a BMI of 27 or higher will take the drug before their scheduled surger…

This pilot study tests a program to help construction workers in Hong Kong quit smoking. Participants will get nicotine gum, a week of nicotine replacement therapy samples, and 12 weeks of support from a chatbot via WhatsApp. The study will see if this combined approach is practi…

This study tests whether chewing xylitol gum for 4 weeks, along with text reminders, helps daily smokers cut down or quit. About 134 Hong Kong adults who smoke at least one cigarette daily will be split into two groups: one gets the gum and support, the other gets brief advice on…

This study tests a special type of acupuncture (DCEAS+BA) in 148 teens aged 15-22 who have mild to moderate anxiety or depression. Participants get either the real treatment or a sham version twice a week for 8 weeks. Researchers will measure changes in anxiety, depression, sleep…

This study tests if acupuncture can lower pain and the need for painkillers after hemorrhoid removal. About 100 adults having surgery for severe hemorrhoids will get either real acupuncture or a sham version over 5 days. Researchers will track pain levels, medication use, and rec…

This study tests a 5-week digital breathing program (heart rate variability biofeedback) to see if it improves well-being in people with first episode psychosis. 80 participants will either do the breathing exercises or listen to music. The goal is to reduce symptoms like depress…

This study tests whether a brief sleep therapy group, led by trained laypersons, can improve sleep quality in older adults in Hong Kong. Fifty participants aged 45 and older with mild depression and sleep problems will either join the group or receive a self-help booklet. The goa…

Researchers in Hong Kong are studying whether sleep patterns can help predict postpartum depression (PND). Sixty new mothers within 6 months of giving birth will wear an actigraphy watch for 14 days to track their sleep. The study aims to create a risk index for PND based on slee…

This study follows 178 people who had a first episode of psychosis to see how early medication choices and relapses affect their thinking, daily life, and mental health over 20 years. Participants will have a one-time interview with a research assistant. The goal is to learn what…

This study tests whether home visits from younger volunteers and AI-generated digital tools can encourage older adults (65+) in Hong Kong to join a District Health Centre. About 180 participants who are not yet members will be tracked for 3 months to see if these approaches work.…

This study looks at whether a simple 3-step program—assess, advise, refer—can help cancer survivors get more exercise as part of their regular care. About 1,800 patients who finished cancer treatment in the last 5 years and have a higher BMI will take part. The goal is to see if …

This study tests a program called ReFrame-R that teaches older adults in Hong Kong how to communicate better with their adult children. The goal is to see if this training can improve family relationships and give older adults a stronger sense of purpose. About 40 Cantonese-speak…

This study aims to find early signs of diseases like heart disease, diabetes, and cancer by analyzing blood samples over time. Researchers will collect health data and blood from 15,000 adults aged 40-70 to create personalized health baselines using artificial intelligence. The g…

This study aims to see if a urine test for HPV is acceptable and effective for cervical cancer screening in the community. About 8,620 women aged 26-65 will provide a urine sample at home or a clinic. If the urine HPV test is positive, a follow-up DNA test will help decide who ne…

This study tests a program called ChatACP that sends daily messages and uses a chatbot to help family members of nursing home residents prepare for advance care planning—discussions about future medical and personal care. About 60 family members will use the program for 10 days a…

This study tests whether a nurse-led discharge program helps patients become more active in managing their own health after leaving the hospital. About 120 adults in Hong Kong who are stable enough to go home will take part. Researchers will measure changes in patient activation …

This study will test if a camouflaged WeChat mini-program is a feasible and acceptable way to support Chinese immigrant women in Hong Kong who have experienced intimate partner violence. About 86 women aged 18 to 45 will use the program and provide feedback. The goal is to see if…

This study looks at kidney tissue from people with hepatorenal syndrome (HRS) who are getting a liver transplant. Researchers want to see if the kidney damage is permanent or reversible, which could change how doctors treat this condition. About 42 adults will take part, and they…