The University Of Hong Kong

This study looks at how getting the flu vaccine year after year changes your body's immune response. Researchers are testing two types of flu vaccines—a nasal spray (FluMist) and a shot (Flublok)—in 600 adults aged 22 to 50 in Hong Kong. They will measure antibodies and immune ce…

This study tests whether placing vancomycin powder directly into the surgical wound before closing it can prevent infections after open spine surgery. The trial includes 76 adults at high risk for infection due to spinal deformity, trauma, or tumor. Half receive the powder plus s…

This study tests whether a gel made with silver diamine fluoride can stop cavities in preschool children as well as the liquid version. About 630 healthy kids with at least one cavity will get the gel or solution every six months for 30 months. Researchers will check if the cavit…

This study tests whether mobile health support (text messages and chat-based coaching) and financial incentives (up to HK$500) can help 1200 older, low-income smokers in Hong Kong quit. Participants are aged 60+ and smoke daily. The main goal is to see if these approaches lead to…

This study tests whether empagliflozin, a diabetes drug, can prevent liver scarring (fibrosis) from getting worse in people with chronic hepatitis B. About 106 participants with moderate to severe liver scarring will take either empagliflozin or a placebo daily for three years. T…

This study tests whether taking teriparatide (a bone-building drug) for one month before lumbar fusion surgery helps surgeons place screws more securely in patients with osteoporosis. About 192 participants will be randomly assigned to receive either the drug or no pretreatment. …

This study tests whether artificial intelligence (AI) can design dental crowns as well as a human technician. Forty adults with a damaged back tooth will receive either an AI-designed crown or a standard computer-designed one. Researchers will check for cracks, loosening, and ove…

This study tests a new, non-invasive treatment called histotripsy that uses high-intensity ultrasound waves to destroy liver tumours without cutting the skin. It works by creating tiny bubbles inside the tumour that rapidly expand and collapse, breaking apart the cancer cells whi…

This study tests whether a smartphone app can help Chinese adults with non-alcoholic fatty liver disease (NAFLD) lose weight over 12 months. Weight loss is currently the only proven way to reduce liver fat and prevent serious liver damage. The app provides health tips and trackin…

This study tests whether the blood thinner dabigatran is as safe and effective as warfarin for preventing strokes in people with atrial fibrillation (irregular heartbeat) and moderate to severe mitral stenosis (narrowed heart valve). About 370 adults will take either dabigatran o…

This study tests whether an AI-powered mobile app can help older adults in Hong Kong improve their gum health. 88 participants aged 60 and older will receive personalized oral hygiene instructions based on photos of their gums analyzed by the app. Trained volunteers will provide …

This study tests a program called De-HF that helps heart failure patients and their family caregivers work together to manage the condition. The program includes both in-person and online support to improve quality of life and reduce hospital stays. About 232 patient-caregiver pa…

This study tests a smartphone app called ausculto™ that records and analyzes heart sounds to detect congenital heart disease. Researchers will record heart sounds from 220 people aged 6 and older who have had recent echocardiograms. The goal is to see if the app can accurately te…

This study tests whether smartphones can accurately detect atrial fibrillation (AF), a common heart rhythm problem, using built-in microphones, cameras, and small external sensors. About 209 adults with or without AF will have their heart sounds, electrical activity, and blood fl…

This study tests a silver diamine fluoride (SDF) gel to prevent cavities in 1,500 healthy preschool children. The gel is applied every six months for two years and compared to standard fluoride varnish. The goal is to see if the SDF gel better protects teeth from decay.

This study tests whether adding a special glass material to standard fluoride varnish can better prevent root cavities in adults over 60. Researchers will compare the two varnishes in 540 older adults over 36 months. The goal is to see which one reduces new cavities and helps sto…

This study tests whether reading comics about tobacco can help primary school students learn about the dangers of smoking and develop anti-smoking attitudes. About 1,000 students in Hong Kong will either read comics or information sheets. Researchers will compare their knowledge,…

This study tests an 8-week program that helps people with mild dementia and their caregivers identify and use their strengths. The program includes workshops and a biography activity led by trained volunteers. Researchers will measure changes in thinking skills and caregiver conf…

This study tests a 2-week treatment that combines gentle brain stimulation (tDCS) with virtual reality meditation to reduce anxiety. 52 adults with generalized anxiety disorder or similar conditions will receive either real or fake stimulation alongside VR meditation. Researchers…

This study tests if group cognitive behavioral therapy (CBT) can reduce anxiety and insomnia in teens aged 12-20. About 171 participants with both conditions will receive either CBT for anxiety or CBT for insomnia. The goal is to see which approach better improves symptoms, sleep…

This study tests a new type of brain training for children with ADHD. It uses a device that measures brain activity and gives feedback, sometimes with virtual reality goggles. The goal is to see if this training can improve attention and reduce hyperactivity. About 110 children a…

This study tests a brain training method called neurofeedback, combined with cognitive exercises, to help children aged 6-18 who had a brain tumor and now have trouble with attention or memory. Half of the 50 participants get real neurofeedback, the other half a sham version, and…

This study tests whether a mobile app called SUPPORT+ can improve quality of life for adults with advanced cancer who are receiving palliative care. The app prompts users to report symptoms weekly, offers self-care tips, and alerts nurses if symptoms are severe. Researchers will …

This study looks at whether exercising once a week or three times a week is better at reducing liver fat in adults who are centrally obese and have non-alcoholic fatty liver disease (NAFLD). Three hundred Chinese adults aged 18-69 will be assigned to either a once-weekly or thric…

This study tests whether a smartphone-based support system can help first-time mothers in Hong Kong breastfeed exclusively for longer. About 518 mothers will receive either the app-based support or standard care. The goal is to see if real-time, personalized help improves breastf…

This study tests whether automated text messages teaching acceptance and commitment therapy can help older adults with mild cognitive impairment manage mood and behavioral symptoms. Forty participants will receive the text-based program or usual care. The goal is to see if this a…

This study tests whether a personalized care plan, based on a geriatric assessment, can reduce severe side effects in older adults (65+) starting chemotherapy for common cancers. Participants are randomly assigned to receive the assessment-driven plan plus usual care, or usual ca…

This study was designed to see if cognitive behavioural therapy for insomnia (CBT-I) could help teenagers with ADHD who also have trouble sleeping. The researchers planned to measure changes in sleep, ADHD symptoms, and mood. However, the trial was withdrawn before any participan…

This study follows 54 people with chronic hepatitis B who stop taking their antiviral medication after at least three years. Researchers will closely monitor their immune system and virus levels to see what happens during a flare. The goal is to learn whether a controlled flare m…

This study tests whether a single session of a self-corrective exercise can immediately improve muscle activity and spinal alignment in 40 adolescents with idiopathic scoliosis. Participants do both a standard exercise and the self-corrective exercise, and researchers measure cha…

This study looks at whether a digital program called Digital Connect can help homebound older adults (age 65+) maintain their physical and mental health. Over 1,000 participants in Hong Kong will use the program, and researchers will measure changes in quality of life, memory, lo…

This study tests a community parenting program called 'Amazing Start' for families with young children facing challenges like low income or single parenthood. About 270 families in Hong Kong are randomly assigned to either receive the program or wait. Researchers will check if th…

This study tests whether a nurse-led health coaching program helps women aged 45 to 64 in Hong Kong manage their health better. About 1,728 women will either get the nurse-led program or general health advice. The goal is to see if the program leads to better use of medical resou…

This study tests whether 3D-printed, custom-made titanium plates help surgeons rebuild the jaw more accurately and quickly than standard plates. About 92 adults with jaw tumors, deformities, or other conditions will be randomly assigned to receive either type of plate during surg…

This study tests a short, phone-based mindfulness and lifestyle coaching program for caregivers of people with brain diseases like Alzheimer's or Parkinson's. Many caregivers are inactive, raising their risk for heart disease and shortening their lives. The program uses text mess…

This study tests whether an artificial intelligence (AI) tool can help medical students and doctors more accurately determine the stage and risk level of thyroid cancer. About 70 participants will review patient cases, some with AI help and some without. The goal is to see if the…

This study is looking at CT scans of the heart from 22,000 people who had chest pain. Researchers want to see if certain features of plaque (fatty deposits) in the heart arteries can help predict who will later have a heart attack, stroke, or die from heart disease. The goal is t…