Sixth Affiliated Hospital, Sun Yat-sen University

This study is for adults with active Crohn's disease who are not getting enough benefit from their current standard dose of ustekinumab. It will compare the safety and effectiveness of adding a second drug (upadacitinib) to the current treatment versus just giving a higher dose o…

This study aims to find out if chemotherapy is necessary for some patients with locally advanced colorectal cancer who have already responded well to pre-surgery treatments. Researchers will compare outcomes between patients who receive standard follow-up chemotherapy and those w…

This study is for people with a specific type of rectal cancer that has completely disappeared after immunotherapy. Instead of having major surgery, which can cause lasting side effects, participants will be closely monitored to see if the cancer stays away. The goal is to see if…

This study is testing whether adding a PD-1 immunotherapy drug to standard chemotherapy and radiation improves outcomes for people with a rare type of rectal cancer. It will enroll about 20 adults with newly diagnosed, non-metastatic rectal squamous cell carcinoma. The main goal …

This study looks back at medical records to compare two types of minimally invasive breast cancer surgeries: robot-assisted and endoscopic approaches. Researchers will examine 200 women with early-stage breast cancer who had one of these procedures. The goal is to understand whic…

This study is testing whether a special liquid-only diet, called exclusive enteral nutrition (EEN), can help adults with active and complicated Crohn's disease. Researchers will follow 300 participants for 12 weeks to see if the diet reduces symptoms, improves gut health, and is …

This study is testing a new three-part treatment for people with high-risk colon cancer that doesn't typically respond well to immunotherapy alone. It combines a special type of radiation designed to spare lymph nodes, followed by chemotherapy and an immunotherapy drug (PD-1 inhi…

This study looks back at the medical records of 150 adults with moderate-to-severe ulcerative colitis (UC) to see which treatment approach worked better in real life. It compares patients who took a pill called upadacitinib by itself to those who took that same pill along with an…

This study is testing whether a precise, high-dose radiation treatment can help control rectal cancer that has come back and cannot be removed by surgery. The goal is to see if this treatment can shrink tumors enough to make surgery possible or extend survival. The trial will enr…

This study is testing if adding treatment for a common stomach bacteria (H. pylori) to standard chemotherapy works better for patients with locally advanced stomach cancer. About 200 participants will receive chemotherapy before and after surgery. Half will also get the H. pylori…

This study is testing a new three-part treatment for people with high-risk colon cancer that hasn't spread. The goal is to shrink the tumor as much as possible before surgery. Patients receive a very low dose of radiation designed to spare lymph nodes, along with standard chemoth…

This study is testing a special type of MRI scan to see if it can accurately tell whether a patient's rectal cancer has been completely eliminated by their initial treatment (chemotherapy/radiation) before they have surgery. The goal is to help doctors better decide which patient…

This study is testing if carefully adjusting anesthesia medicine doses during surgery can prevent dangerous drops in blood pressure in older adults. Researchers will compare this personalized dosing method to standard fixed doses in 500 patients aged 65+ having abdominal surgery.…

This study aims to find out which of two surgical techniques for low rectal cancer leads to better bowel function and quality of life after surgery. Researchers will compare the Parks operation and the Bacon operation in 256 patients. The main goal is to see which technique resul…

This study is testing if a drug called megestrol acetate can help people with locally advanced colon or rectal cancer avoid losing weight during chemotherapy given before surgery. The trial will involve 60 patients, with half receiving the drug alongside their standard chemo and …

This study aims to understand how bacteria in the gut might influence whether colorectal cancer spreads to other parts of the body. Researchers will collect tissue and stool samples from 300 people with colorectal cancer, comparing those whose cancer has spread with those whose h…

This study aims to better predict and monitor heart problems in cancer patients receiving chemotherapy. Researchers will follow 5,000 adults, using regular blood tests and heart scans to try to spot early signs of damage. The goal is to build a system that identifies patients at …

This study aims to see if taking the diabetes medication metformin before surgery affects how often or how badly patients feel nauseous or vomit afterwards. Researchers will observe and compare 909 patients having surgery—some who already take metformin and some who do not. The g…

This study aims to test a new prediction model that uses multiple types of patient data to forecast how well someone's rectal cancer will respond to treatment given before surgery. Researchers will enroll 106 patients with locally advanced rectal cancer to see if the model can ac…

This study aims to understand how different patterns of rectal injury from radiation therapy affect a patient's long-term recovery. Researchers will observe 150 patients over time, collecting medical information and test results without changing their treatment. The goal is to fi…