Sixth Affiliated Hospital, Sun Yat-sen University

This study tests a new treatment plan for people with moderate to severe ulcerative colitis (UC). It combines two drugs: upadacitinib, which works quickly to reduce symptoms, followed by vedolizumab, which is safer for long-term use. The goal is to see if this sequence can help p…

This study watches how well IL-23 inhibitors work for adults with active Crohn's disease in everyday medical practice. About 665 participants will get treatment chosen by their doctor and be checked at 12 and 52 weeks for symptom relief, healing, and side effects. The goal is to …

This study tests a cancer drug (PD-1 antibody) given before surgery to people who have two or more colorectal cancers at the same time. Some participants will also get chemotherapy. The goal is to see if the drug can shrink or eliminate the tumors, making surgery more effective. …

This study tests a new treatment for people whose rectal cancer has returned and cannot be surgically removed. The approach combines targeted radiation (SBRT) with an immunotherapy drug (PD-1 antibody) to try to shrink tumors and improve survival. About 31 participants will recei…

This study tests whether adding H. pylori bacteria treatment to standard chemotherapy before and after surgery can improve outcomes for people with stomach or gastroesophageal junction cancer. About 198 adults with H. pylori-positive, locally advanced cancer will be randomly assi…

This study looks at whether adding a second drug (vedolizumab) to the standard drug upadacitinib works better than upadacitinib alone for people with moderate-to-severe ulcerative colitis. Researchers will review medical records from 150 adults across six hospitals in China to se…

This study is testing a drug called an IL-23 monoclonal antibody in 200 people with moderate to severe Crohn's disease or ulcerative colitis. The goal is to see if it can reduce symptoms and inflammation without the need for steroids. Participants will receive the drug and be fol…

This study compares two types of surgery (Parks and Bacon) for people with very low rectal cancer. The goal is to see which method leads to better bowel function and quality of life one year after surgery. About 256 adults aged 18–75 with tumors close to the anal opening will tak…

This study tests a new approach for people with a hard-to-treat type of colon cancer (pMMR/MSS). The treatment combines low-dose radiation (sparing lymph nodes), chemotherapy, and an immunotherapy drug (PD-1 inhibitor) before surgery. The goal is to see if this combination can ma…

This study tests whether adding a low dose of upadacitinib to standard TNF inhibitor therapy works better than increasing the TNF inhibitor dose alone for people with moderate-to-severe Crohn's disease who aren't getting enough benefit from their current treatment. About 312 adul…

This study tests whether combining two drugs (upadacitinib and ustekinumab) is more effective than increasing the dose of just one drug for people with Crohn's disease who didn't get better with standard treatment. About 214 adults with active Crohn's will be randomly assigned to…

This study looks at whether a special liquid diet, called exclusive enteral nutrition (EEN), can help adults with active Crohn's disease feel better and reduce inflammation. About 300 participants will use EEN as their main treatment for 12 weeks. Researchers will track remission…

This study looks at whether people with a certain type of rectal cancer (dMMR/MSI-H) can safely avoid surgery if their tumor disappears after immunotherapy. Standard treatments like surgery or chemo can cause lasting side effects, including loss of bowel control or needing a perm…

This study tests whether adding an immunotherapy drug (PD-1 antibody) to standard chemoradiation can improve outcomes for people with newly diagnosed rectal squamous cell carcinoma that hasn't spread. About 20 participants will receive chemotherapy, radiation, and the immunothera…

This study tests a new approach for people with a common type of high-risk colon cancer that doesn't respond well to immunotherapy alone. The treatment combines a special type of radiation that spares lymph nodes, followed by chemotherapy and an immunotherapy drug. The goal is to…

This study tests a high-precision radiation treatment called SBRT for people with rectal cancer that has returned after initial treatment and cannot be removed by surgery. The goal is to see if SBRT can stop the tumor from growing for at least a year and improve survival. About 4…

This study tests whether a nerve block (superior hypogastric plexus block) can help people recover better after laparoscopic surgery for colorectal cancer. About 170 adults having this surgery will be randomly assigned to receive the nerve block or not. The main goal is to see if…

This study tests whether megestrol acetate, a drug that boosts appetite, can help prevent weight loss in people with locally advanced colorectal cancer who are receiving chemotherapy before surgery. About 60 adults will take either megestrol or a placebo during their chemo. The g…

This study tests whether giving anesthesia drugs in personalized, adjusted doses (instead of fixed doses) can reduce dangerously low blood pressure during laparoscopic abdominal surgery in people aged 65 and older. About 500 participants will receive either the adjusted or standa…

This study follows 150 people with radiation rectal injury to see how different types of the condition affect recovery. Researchers will collect medical records, test results, and follow-up data but will not change any treatments. The goal is to better understand which patients a…

This study looks at whether patients with locally advanced colorectal cancer that improved to stage II after pre-surgery chemotherapy or chemoradiotherapy still need additional chemotherapy. Researchers will follow 650 participants to compare disease-free survival and side effect…

This study observes 909 adults having surgery under general anesthesia to see if taking metformin (a diabetes medicine) changes their risk of nausea and vomiting after the operation. Researchers will compare those already on metformin with those not taking it, using surveys to tr…

This study looks at whether the bacteria in your gut can help predict if colorectal cancer will spread. Researchers will collect tumor tissue, normal tissue, and stool samples from 300 people with colorectal cancer to compare bacterial patterns between those whose cancer has spre…

This study tests whether an artificial intelligence (AI) system can analyze MRI scans to predict how well rectal cancer responds to chemotherapy and radiation before surgery. Researchers will enroll 1,700 adults with locally advanced rectal cancer. The goal is to help doctors ide…

This study looks back at the results of two types of breast-conserving surgery for breast cancer: one done with a robot and one done with an endoscope. The goal is to see which method leads to fewer complications and better cosmetic results. About 200 women aged 18 to 80 with ear…

This study aims to create a model that uses multiple types of patient data to predict whether rectal cancer will completely disappear after chemotherapy and radiation before surgery. Researchers will enroll 106 people with locally advanced rectal cancer and track their health inf…

This study tracks 5,000 cancer patients receiving chemotherapy or targeted drugs to detect heart-related side effects early. Researchers use regular heart tests and blood markers to build a system that predicts serious heart problems. The goal is to improve patient safety and qua…

This study looks at whether a special type of MRI, called amide proton transfer-weighted imaging, can accurately predict if rectal cancer has completely disappeared after chemotherapy and radiation. Researchers will scan 320 people before surgery and compare the scan results to t…