Sixth Affiliated Hospital, Sun Yat-sen University

This phase 3 trial tests whether adding immunotherapy and a targeted drug (based on tumor genetics) to standard short-course radiation and chemotherapy can improve outcomes for people with high-risk rectal cancer that is mismatch repair proficient (pMMR/MSS). About 204 adults age…

This study tests two medications, ustekinumab and upadacitinib, in people with Crohn's disease that hasn't responded to standard treatments. About 454 adults who have already failed or cannot tolerate anti-TNF therapy will receive one of the two drugs. The goal is to see which dr…

This study looks at how well IL-23 inhibitors work for people with inflammatory bowel disease (Crohn's disease or ulcerative colitis) in China. About 178 adults will receive these drugs in regular clinic settings, and researchers will check if symptoms go away and if the bowel he…

This study tests a new treatment for women who cannot get pregnant because of severe scarring inside the uterus (intrauterine adhesions). Doctors will deliver stem cells from bone marrow directly to the uterus through a small tube in the artery. The goal is to repair the uterine …

This study tests whether adding a citrus flavonoid tablet (Aimailang) to standard chemotherapy (mFOLFOX6) can shrink advanced rectal tumors more effectively before surgery. About 236 adults with a specific genetic marker (high YWHAB) will be randomly assigned to get chemo with or…

This study tests whether adding a special diet (Crohn's Disease Exclusion Diet) to standard biologic therapy helps more adults with Crohn's disease achieve complete gut healing. About 185 participants in China will be randomly assigned to receive either the diet plus biologics or…

This study tests whether a special enema, given daily during and shortly after short-course radiation, can prevent rectal injury in 40 rectal cancer patients. The goal is to reduce the high rate of radiation-induced rectal damage from an expected 80% down to 50%. It is a single-a…

This study tests a new type of nerve block (called r-PVB) to see if it can reduce pain and help people recover faster after stoma closure surgery. About 250 adults having this surgery will either get the new block or standard care. The goal is to lower pain scores and improve ove…

This study compares a new imaging technique called red dichromatic imaging (RDI) with standard white-light endoscopy during a procedure to remove early-stage cancers or precancerous growths from the digestive tract. About 158 adults will take part to see if RDI helps doctors work…

This study compares a revised nerve block method to a traditional one for pain relief after video-assisted lung surgery. About 200 adults having elective lung surgery will be randomly assigned to receive either the new or standard block. The goal is to see if the new approach pro…

This study tests a new type of nerve block (r-PVB) to see if it reduces pain and helps patients recover faster after laparoscopic gallbladder removal. The trial will involve 250 adults having planned surgery for non-cancerous gallbladder disease. The approach uses a single inject…

This study tests whether a daily enema with dexamethasone can reduce rectal injury caused by pelvic radiation in rectal cancer patients. About 40 adults aged 18-75 will be split into two groups: one starts the enema early (day 10 of radiation), the other starts only after injury …

This study tests whether a nasal spray called dexmedetomidine, used at night, can help older adults (ages 65-90) sleep better and prevent delirium (sudden confusion) after major abdominal surgery. Half of the 400 participants will receive the spray, and half will receive a placeb…

This study looks at whether the type of anesthesia given during surgery affects lung injury in patients with sepsis. About 480 adults with sepsis who need surgery will be randomly assigned to receive either inhaled or intravenous anesthesia. Researchers will track how many days t…

This study tests an AI-powered smartphone app that lets patients take a photo of their bowel movements after taking prep medicine. The app instantly tells if the bowel is clean enough for a colonoscopy. If not, the clinic can step in early to improve the prep. About 524 adults wi…

This study compares giving 30% oxygen versus the usual 100% oxygen before removing the breathing tube after abdominal surgery. The goal is to see if a lower oxygen level reduces the chance of low oxygen after extubation. About 590 adults having abdominal surgery will take part.