Ottawa Hospital Research Institute

This study tests whether adding rosuvastatin (a cholesterol-lowering drug) to standard blood thinners can lower the risk of another blood clot in people who recently had a deep vein thrombosis or pulmonary embolism. About 2700 adults will receive either rosuvastatin or a placebo …

This study tests whether omeprazole, a common stomach acid drug, can reduce gastrointestinal bleeding in adults aged 65 and older who are taking blood thinners for a blood clot. The trial will enroll 360 participants to see if enough people are willing to join and follow the stud…

This study tests whether a low dose of colchicine, a medicine usually used for gout, can reduce the risk of post-thrombotic syndrome (PTS) after a deep vein thrombosis (DVT) in the leg. PTS can cause pain, swelling, and skin changes long after the clot resolves. The trial will en…

This study tests whether a shorter, lower-dose steroid treatment (4 weeks) combined with standard medications works as well as the usual longer steroid course for people with ANCA vasculitis and severe kidney disease. About 36 adults with a new or returning flare of this conditio…

This study compares two common blood thinners, rivaroxaban and apixaban, to see which causes less bleeding in people with atrial fibrillation (an irregular heartbeat). About 3,000 adults with newly diagnosed AF will be randomly assigned one of the two drugs and monitored for blee…

This study tests whether giving a drug called tranexamic acid (TXA) along with platelet transfusions only when needed is safer and works better than giving platelet transfusions preventively. About 662 adults with blood cancers who are getting their own stem cells transplanted wi…

This study tests if removing nasal polyps in a doctor's office works as well as surgery in a hospital operating room for people with chronic sinusitis. About 140 adults with nasal polyps will be randomly assigned to one of the two treatments. The goal is to see if the cheaper, fa…

This study tests if doing a home-based exercise program before surgery can reduce disability 90 days after the operation. About 902 adults scheduled for major surgery will be split into two groups: one that follows the online exercise program and one that receives usual care. The…

This study looks at whether breast cancer patients can safely skip a medication called G-CSF during one part of their chemotherapy to reduce bone pain. About 242 people with early-stage breast cancer will either take G-CSF as usual or skip it while receiving paclitaxel. The main …

This study looks at whether taking endocrine therapy in the morning or evening makes a difference for people with metastatic breast or prostate cancer. About 50 participants will be randomly assigned to take their medication at one of these times. The main goal is to see if a lar…

This small study tests whether using a vacuum erection device every day for six months can help men who have lost sensation in their penis. Eight adult men will use the device at home and report their experiences through questionnaires. The goal is to see if this approach is prac…

This study tests whether adding personalized integrative care—like naturopathic support, a Mediterranean diet, and physical activity—before and after surgery can improve quality of life and reduce complications for people with lung, stomach, or esophageal cancer. About 20 adults …

This study looks at whether taking the chemotherapy drug temozolomide at a specific time of day (morning vs evening) helps people with a type of brain cancer called glioblastoma. About 50 adults who have already had surgery and radiation will be randomly assigned to take their ch…

This early-stage study tests whether a fractional CO2 laser can safely reduce the scar tissue that causes penile curvature in Peyronie's disease. About 60 men with stable disease for at least a year will receive three laser sessions over 18 weeks. The main goal is to check for si…

This study tests whether modafinil, a drug that promotes wakefulness, can reduce severe fatigue and thinking problems in people with advanced cancer. About 40 adults with stage III or IV cancer will receive either modafinil or a placebo for a short time. The goal is to see if the…

This study looks at whether a quick test of heart and breathing patterns before major chest surgery can help predict which patients will have complications afterward. Researchers will enroll 130 adults undergoing surgery for lung, esophageal, or stomach cancer. The goal is to see…

This study looks at how well people with type 2 diabetes can produce insulin after drinking a meal replacement shake. Researchers will take blood samples over two hours to measure insulin and blood sugar levels. The goal is to understand how recent weight gain might affect the bo…

This study looks at whether adding a hip arthroscopy (a minimally invasive procedure) to a standard PAO surgery improves recovery and quality of life for people with hip dysplasia. About 204 participants aged 16–50 will be randomly assigned to receive either PAO alone or PAO plus…

This study tests a decision-support tool called the Extubation Advisor (EA) that helps doctors decide when to safely remove a breathing tube from critically ill patients. About 200 adults on ventilators for more than 48 hours will take part. The tool combines patient data with ri…

This study aims to find people who have asthma or COPD but don't know it yet. Participants will complete an online questionnaire to see if they are at risk. Those at risk will be randomly assigned to receive early diagnosis and treatment from their doctor or usual care. The goal …

This study looks at whether a brain MRI can predict if someone will be satisfied after knee replacement surgery. About 1 in 5 patients still have pain or trouble moving after surgery, and doctors can't predict who. Researchers will scan the brains of 50 adults before and after su…

This study tests whether using a remote heart monitor for 15 days after leaving the emergency room can find dangerous heart rhythms in people who fainted. About 580 adults at medium or high risk for heart problems will be randomly assigned to either standard care or extended moni…

This pilot study is checking if it's possible to run a larger trial comparing inducing labor at 38 weeks versus waiting for labor to start naturally in pregnant people with gestational diabetes. About 260 participants will be randomly assigned to one of two groups. The main goal …