Ottawa Hospital Research Institute

This study compared two blood thinners, rivaroxaban and apixaban, to see which causes fewer bleeding problems in people with blood clots in the legs or lungs. About 2,760 adults took part, and researchers tracked serious and minor bleeding events. The goal was to help doctors cho…

This study looked at whether a single dose of the bone drug zoledronate works as well as getting it every six months for three years in people with early-stage breast cancer. The goal was to see if a simpler treatment plan could still help prevent cancer from spreading to the bon…

This study looked at whether the MyChart app can be used to track hot flash treatments in breast cancer patients. About 56 adults with breast cancer and hot flashes took part. The goal was to see if patients and doctors would use the app to report symptoms, not to test a new trea…

This pilot study tested two simple, drug-free therapies—time-restricted eating and blue-blocking glasses—for people hospitalized with mania from bipolar disorder. The goal was to see if these approaches are feasible and safe, and whether they can help calm manic symptoms and rest…

This study compared two types of skin grafts (Alloderm and Dermacell) used in immediate breast reconstruction after mastectomy for breast cancer or prevention. 62 women participated, and researchers looked at complications like infection, fluid buildup, implant loss, and the need…

This study looked at 245 women with early-stage hormone-sensitive breast cancer to see if taking their daily hormone therapy in the morning or evening made a difference in side effects and quality of life. Participants were randomly assigned to take their medication either in the…

This study looked at whether a personalized follow-up schedule is better than standard guidelines for women who finished treatment for early-stage breast cancer. 261 participants were randomly assigned to either a tailored plan or the usual every-3-to-6-month visits. The goal was…

This study tested whether a mobile app-based speech therapy program is practical for stroke survivors with mild to moderate communication problems. Twenty patients discharged from the hospital used an iPad for therapy at home while waiting for outpatient services. The main goal w…

This study tested whether a home-based exercise program, supported by an online platform, could help people get fitter before surgery. Half of the 144 participants did the program, while the other half received usual care. The main goal was to see if the program was practical and…

This study looked at 200 women with early-stage breast cancer who were taking trastuzumab, a drug that can sometimes harm the heart. Researchers compared two different schedules for checking heart function to see which one works better. The goal was to find the safest and most ef…

This study tested whether paramedics could use a simple checklist (the Canadian C-Spine Rule) to decide which low-risk trauma patients really need a neck brace and backboard during ambulance transport. Over 3,600 patients took part. The goal was to reduce unnecessary immobilizati…

This study looked at 744 people who had a blood clot before to see if doctors can better predict when another clot will happen. Researchers tested three common tools that use symptoms and medical history to decide if more tests are needed. The goal is to avoid missing dangerous c…

This study looked at whether providing doctors with a free online risk calculator (PREDICT 2.1) changes how often they order a costly genomic test (Oncotype DX) for patients with early-stage breast cancer. About 600 patients took part, and researchers tracked test orders and trea…

This study compared two common blood thinners, rivaroxaban and apixaban, to see which causes less bleeding in people with blood clots. It involved 72 adults with new clots in the legs or lungs. The main goal was to test if a larger study is possible, not to declare a winner.