Ottawa Hospital Research Institute

This study tests a community-based program called the Bridge Model to help people struggling with nicotine and substance use disorders. The program focuses on social needs like housing, jobs, and connections, not just quitting. Researchers will enroll 250 people in Ottawa and Tor…

This study looks at whether taking oral antibiotics the day before planned colon surgery can lower the chance of getting an infection after the operation. About 630 adults having elective colon surgery will be randomly assigned to receive either antibiotics or no antibiotics. The…

This study looks at whether people with breast or prostate cancer that has spread to the bones can safely stop or reduce their bone-strengthening medication after taking it for at least two years. The goal is to see if this approach maintains quality of life and prevents bone com…

This study looks at whether women with early-stage HER2-positive breast cancer who have a complete response to initial chemotherapy and HER2-targeted therapy can safely receive only 6 months of further HER2-targeted treatment instead of the usual 12 months. The goal is to reduce …

This study compares two ways to help people who are homeless or at risk of homelessness quit smoking: nicotine mouth spray or a medication called Cytisine, both with counseling. About 200 adults in Ottawa and Toronto who smoke or vape will take part for six months. The goal is to…

This study tests whether a higher dose of the oral antibiotic cephalexin can better treat cellulitis, a common skin infection, in adults visiting the emergency department. About 446 participants will receive either standard or high-dose cephalexin to see if the higher dose reduce…

This study tests whether starting hormone therapy every other day for a month before switching to daily dosing helps patients tolerate it better and stay on track. About 240 adults with early-stage hormone-sensitive breast cancer will be randomly assigned to either standard daily…

This study looks at whether women aged 70 and older with a less aggressive type of breast cancer can avoid taking hormone therapy after surgery. The goal is to see if skipping this treatment reduces side effects without increasing the risk of cancer coming back. About 100 partici…

This study follows 200 adults who had minimally invasive surgery for conditions like achalasia, hernia, or GERD. Researchers will send yearly questionnaires to check quality of life and symptoms, and review medical records. The goal is to understand long-term outcomes, not to tes…

This study is a practice run for a larger trial comparing two ways to treat chronic sinusitis with nasal polyps: a small procedure done right in the doctor's clinic versus standard sinus surgery in an operating room. The clinic procedure may offer faster recovery and lower costs.…

This study looks at why homeless youth in Ottawa use tobacco, cannabis, and other substances together. Researchers will follow 520 at-risk youth aged 16 and older to understand their substance use patterns. Participants will receive a 6-month program with peer support and a menta…

This study enrolls 500 adults with neuromuscular diseases to collect blood, tissue, and imaging data. The goal is to identify genetic markers and other clues that can help doctors diagnose these rare conditions faster and better understand how the diseases progress. Participants …

This study aims to improve how doctors diagnose neuromuscular diseases (like muscular dystrophy) by using whole-body MRI scans instead of invasive muscle biopsies. Researchers will collect MRI data from 1,000 patients across 14 centers to identify patterns of muscle damage. The g…