Milton S. Hershey Medical Center

This study tests whether a short video of cancer survivors sharing their stories can encourage parents to get their 9- to 12-year-old children the HPV vaccine, which prevents certain cancers. About 200 parents of unvaccinated children will be randomly assigned to watch either the…

This study is testing an investigational drug called angiotensin-(1-7) to see if it can improve cardiovascular health in people who have both obesity and high blood pressure. Researchers will measure nerve activity and artery function during a short infusion of the drug compared …

This study tests whether strictly avoiding low blood sugar (hypoglycemia) can help adults with type 1 diabetes regain the ability to feel symptoms of low blood sugar. About 324 participants with impaired awareness of hypoglycemia will use a closed-loop insulin system and educatio…

This study looks at how much exercise works best to lower liver fat in people with nonalcoholic fatty liver disease (NAFLD) and its more serious form, NASH. There is no approved drug for this condition, so exercise is a key treatment. The trial will enroll 45 sedentary adults age…

This study tests a new treatment called Phase-Based Treatment (PBT) for preteen children with problematic sexual behavior. About 42 children aged 4 to 12 and their caregivers will take part. The goal is to see if PBT works better than the usual care currently offered.

This study tests an herbal supplement called INM176 in 45 men with prostate cancer whose PSA levels are rising after prior treatment or who are on active surveillance. The goal is to find a safe dose and see if the supplement can stabilize or lower PSA levels over six months. Par…

This study tests whether giving low-income adults with type 2 diabetes vouchers to buy fruits and vegetables helps them attend diabetes education classes and improves their blood sugar control. About 120 participants will be randomly assigned to receive different levels of suppor…

This study tests a new oral drug, AMXT 1501, combined with another drug called DFMO for children and young adults (up to age 21) with certain cancers like neuroblastoma, brain tumors, and sarcomas. The first part finds the safest dose, and the second part checks if the combo help…

This study tests a transitional care program for adults with cirrhosis and severe swelling (fluid overload) who are being discharged from the hospital. Participants get a digital scale, educational materials, weekly check-in calls, and a follow-up appointment within 4 weeks. Rese…

This study tests an experimental pill called silmitasertib combined with standard chemotherapy in children and young adults (under 30) whose solid tumors (like neuroblastoma or sarcoma) have come back or not responded to treatment. The goal is to find a safe dose and see if the c…

This study is for people with blood cancers who are getting a stem cell transplant from a donor. It tests whether a lower dose of a drug called cyclophosphamide can prevent a serious side effect called graft-versus-host disease (GVHD), where donor cells attack the body. The goal …

This study looks at whether nicotine pouches can help people who smoke at least 5 cigarettes a day reduce their smoking by 75% over 16 weeks. Participants will be assigned to different nicotine strengths and flavors of pouches. Researchers will measure changes in harmful chemical…

This study is testing a new, low-cost skin sensor that measures salt in sweat to diagnose cystic fibrosis. Researchers will compare the sensor's results to standard lab tests in 30 adults—some with CF and some healthy. The goal is to see if this wearable device can make diagnosis…

This study tests whether sending information and making two phone calls can encourage older adults with osteoarthritis to join SilverSneakers exercise programs. About 1,454 seniors across the U.S. who have free access but haven't used it will be followed for two years. The goal i…

This study looks at whether practicing yoga can reduce pain in women with endometriosis. About 30 women aged 18 to 45 who have moderate pain and a confirmed diagnosis will take part. They will do yoga sessions and report their pain levels using questionnaires. The goal is to see …

This study looks at whether a parent's ability to manage their own emotions can change how well parent training works for children with ADHD. Researchers will work with 65 parents of children ages 5-12 who have ADHD and mild oppositional behavior. The goal is to see if parents wi…

This early study is testing whether a commercially available oil made from two cannabis compounds (CBG and CBD) is safe and can help reduce nerve pain, numbness, and tingling caused by chemotherapy. About 12 adults who finished platinum-based chemo for stomach or bowel cancers wi…

This pilot study tests a virtual exposure therapy for 16 teens aged 14-17 with anorexia nervosa. The therapy helps them face fears about weight gain through exercises like weighing themselves and creating meal plans. Parents are involved as supporters. The goal is to reduce anxie…

This study aims to see if college students can effectively deliver cognitive-behavioral therapy (CBT) to high school students in rural Pennsylvania who are dealing with depression, anxiety, or stress. About 40 teens aged 13-18 will take part. The goal is to provide a low-cost, ac…

This study tests a coaching program that helps young adults who have finished cancer treatment talk more easily with their friends. The goal is to reduce feelings of anxiety, depression, and loneliness. Ten survivors will try the program, and researchers will see if it works and …

This study looks at two common treatments for chronic insomnia: cognitive behavioral therapy (CBT-I) and a low-dose medication called trazodone. Researchers want to see if these treatments work differently depending on whether a person sleeps very little or a normal amount. The g…

This study is testing a new AI-powered chatbot that helps teens and young adults with eating disorders feel less anxious about gaining weight. About 20 people will use the chatbot as an extra tool during their first six weeks in a treatment program. Researchers will check if the …

This study looks at how well different treatments work for pain after a limb is surgically removed. About 350 adults having an amputation at Penn State Hershey Medical Center will rate their pain at rest and with movement over one year. The goal is to find better ways to manage p…

This study looks at whether a technique called 'open weighing'—where patients see their weight during treatment—can help teens and young adults with eating disorders feel less anxious about gaining weight. About 70 participants aged 12 to 24 will be randomly assigned to either op…

This study tests whether a single mindfulness session before endometriosis surgery can help reduce pain and the need for painkillers afterward. About 20 adults with endometriosis will either receive the mindfulness training or standard education before their operation. Researcher…

This study aims to help people from underserved communities have important conversations about end-of-life care and complete advance directives. Researchers will use trusted community networks to test two conversation tools with 1,500 adults. The goal is to improve care quality a…

This study looks at how smoking little cigars affects levels of harmful chemicals and stress on the body compared to regular cigarettes. Fifty daily smokers will try two types of little cigars and their usual cigarette. Researchers will measure markers of oxidative stress and nic…

This study follows 800 people who recently had acute pancreatitis to see who develops diabetes and why. Participants are monitored for 3 years with tests and surveys, but no new treatments are given. The goal is to better understand the link between pancreatitis and diabetes.

This study looks at how stretching veins triggers a reflex that changes nerve activity and blood pressure. Researchers will give healthy adults an anti-inflammatory drug to see if it blocks this reflex. The goal is to better understand basic body functions, not to treat a disease…

This study looks at whether an online training module called iLookOut can help childcare workers better understand when and how to report suspected child abuse. Over 35,000 paid or volunteer staff at childcare facilities in Pennsylvania are taking part. The training aims to impro…

This study looks at whether stretching the veins in your legs can cause a rise in blood pressure when you stand up. Researchers will measure nerve activity and blood pressure in 30 adults. The goal is to better understand a condition called orthostatic hypertension.

This study looks at whether a special computer program can help doctors better manage blood sugar levels in hospitalized adults. The tool alerts care teams when a patient's blood sugar is too high or too low, so they can act quickly. Researchers will track how long patients stay …

This study looks at small molecules called microRNAs in the saliva of newborns exposed to opioids before birth. Researchers want to see if these molecules can help predict how much medicine a baby needs and how they develop over time. The goal is to find simple, non-invasive mark…

This study looks at whether a simple ultrasound measurement of the superior vena cava (a large vein near the heart) can help doctors decide if a patient needs more fluids during coronary artery bypass surgery. About 120 adults having planned bypass surgery will be enrolled. Resea…

This study aims to find brain markers that can predict whether stimulant medication will help reduce irritability and aggression in children with ADHD. About 136 children with ADHD and high levels of irritability or aggression will take part. Researchers will measure brain activi…

This early-phase study tests whether angiotensin-(1-7), a natural hormone, can improve blood vessel function and lower blood pressure in healthy adults aged 65-80. Researchers will measure nerve activity and blood vessel responses during a hormone infusion. The goal is to underst…

This study follows 800 people who recently had acute pancreatitis to see if a continuous glucose monitor (CGM) can predict who will develop diabetes or pre-diabetes. Researchers will track participants for 36 months using CGM and other tests. The goal is to improve how doctors mo…