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Can a simple tilt test guide fluid therapy in heart surgery?

NCT ID NCT06645327

Knowledge-focused Sponsor: Milton S. Hershey Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tests whether a heart ultrasound measurement called the superior vena cava collapsibility index (SVC-CI) can predict how patients will respond to fluids during coronary artery bypass surgery. Researchers will tilt the operating table (head up then head down) to mimic giving fluids and measure changes in heart output. The goal is to find a cutoff value that identifies which patients need more fluids, potentially improving care for 120 adults undergoing this surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
operating room table tilt test (head up and head down positions)
What this could lead to
If successful, this could give doctors a simple, non-invasive way to decide which heart surgery patients need more fluids, potentially improving recovery and reducing complications.
What could go wrong
This is a small, early-stage study (120 participants) focused on measurement accuracy, not treatment. The table tilt test may not work for all patients, and results may not apply to those with severe heart valve problems or arrhythmias.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 120 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2025

Expected to finish

Jan 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Participants with CAD undergoing CABG utilizing cardiopulmonary bypass

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age ≥ 18 2. Participants with CAD undergoing CABG utilizing cardiopulmonary bypass 3. Participants who are able to consent for themselves 4. Primary language is English Exclusion Criteria: 1. Age less than 18 years of age 2. Participants with CAD undergoing off-pump coronary artery bypass (OP-CAB) 3. Severe cardiac valvular pathologies or active congestive heart failure 4. Participants in active arrhythmia such as atrial fibrillation and atrial flutter at the time of data collection. 5. Participants who are unable to consent for themselves 6. Primary language is something other than English

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Conditions

The condition(s) this trial relates to.

coronary artery disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Coronary artery bypass grafting surgery (CABG)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Penn State Hershey Medical Center

    RECRUITING

    Hershey, Pennsylvania, 17033, United States

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