Milton S. Hershey Medical Center

This study tests whether adding the drug eflornithine (DFMO) to standard chemotherapy can help people with Ewing sarcoma or osteosarcoma live longer without their cancer returning. About 406 participants with different stages of these bone cancers will receive DFMO alongside thei…

This study tests whether giving a short infusion of amino acids during heart surgery can help prevent acute kidney injury, a common complication. Researchers will enroll 130 adults having elective heart surgery with a bypass machine. Half will receive standard care, and the other…

This study will test a behavioral program to improve sleep and daily rhythms in autistic adults aged 18-65 who have sleep problems. The goal is to see if the treatment can improve overall sleep health and be easy to use. About 24 participants will take part, and the findings may …

This study tests whether a low-intensity program of educational texts and emails can help reduce stress and burden for people caring for a loved one with dementia. About 20 caregivers who previously joined an observational study will receive automated supportive messages for six …

This study tests if doing dermabrasion (a procedure that sands the top layer of skin) several times can make surgical scars from head and neck reconstruction look better. Forty adults who had free flap surgery at least 3 months ago will take part. Half of each scar will be treate…

This study tests whether a special collagen shield placed on the eye can reduce pain and the need for painkillers in people who come to the ER with a scratched cornea (the clear front part of the eye). About 60 adults with a scratch in one eye will be randomly assigned to get eit…

This study compares two methods of radiofrequency ablation (a heat-based treatment) for chronic low back pain caused by lumbar spondylosis. 25 adults with long-term pain will be randomly assigned to one of two approaches. The goal is to see which method provides better pain relie…

This study looks at whether a specially adapted conversation game, called the Hello game, can help members of the Washoe Tribe talk about and plan for future medical care. About 108 adults from the tribe will play the game in groups and answer surveys. The goal is to see if the g…

This early-stage study tests whether vitamin B6 can reduce the sharp rise in blood pressure that happens during exercise after a temporary reduction in leg blood flow (simulating injury). Researchers will measure blood pressure, heart rate, and walking time in 30 healthy adults a…

This pilot study will test whether automated, personalized coping messages can help stroke survivors increase their physical activity. About 50 adults who had a stroke 3 months to 3 years ago and can walk independently will receive these prompts over 3 months. The main goal is to…

This study looks at how the loss of estrogen after menopause might increase the risk of heart disease. Researchers will measure blood pressure, nerve activity, and signs of inflammation in 20 healthy postmenopausal women. The goal is to understand the link between estrogen defici…

This study tests whether messages about losing the benefits of exercise can help older adults with walking difficulty stick to a daily routine. About 148 participants will do a 5-minute home exercise program for 4 months and complete online surveys. Researchers want to see if the…

This study tests whether using ultrasound guidance helps doctors place a brain drain (external ventricular drain) more accurately in adults with hydrocephalus. The goal is to reduce the number of needle passes needed and avoid complications. Ten participants will be enrolled, and…