Milton S. Hershey Medical Center

Researchers are testing whether adding tirzepatide, a weekly drug that treats obesity and diabetes, to a standard levonorgestrel-releasing intrauterine device can help clear early endometrial cancer or a precancerous condition called endometrial intraepithelial neoplasia. The stu…

This study tests whether a program that teaches gardening, cooking, and nutrition can improve heart health in adults at risk for cardiovascular disease and their children. Participants will be randomly assigned to the program or a waitlist. The researchers will measure fruit and …

This trial tests whether a single dose of 4-aminopyridine (dalfampridine) can help diagnose recurrent laryngeal nerve paralysis after trauma, surgery, or intubation. Adults with recent nerve injury receive one oral dose before a flexible laryngoscopy exam. Doctors then check for …

This study tests if giving a simple amino acid infusion during heart surgery can prevent acute kidney injury, a common complication. Researchers will measure kidney damage markers in the urine of 130 adults before and after surgery. Half will receive standard care, and the other …

This study tests whether a procedure called dermabrasion, which sands the skin, can improve the appearance of scars from free flap reconstruction in the head and neck. Forty adults who had flap surgery at least three months ago will have half their scar treated and half left alon…

This pilot trial tests whether messages that focus on losing the benefits of exercise can help older adults with walking difficulty stick to a daily 5-minute home exercise program. 148 participants will receive either loss aversion messages or standard reminders and complete surv…

This study tests whether a six-week program of automated text or email messages can help reduce stress and burden for people caring for a loved one with dementia. Twenty care partners who previously took part in an observational study will receive educational tips, stress managem…

This study tests two different methods of radiofrequency ablation (a procedure that uses heat to calm pain nerves) for people with long-term low back pain. The standard method uses a slight angle, while the new method places the needle more straight in from the back. Researchers …

This study tests whether a special collagen shield placed on the eye can reduce pain from a scratched cornea (corneal abrasion) in adults visiting the emergency department. Sixty participants will be randomly assigned to receive either the collagen shield or a fake shield, along …

This study tests two simple ways to help nurses and healthcare staff feel less stressed at work: a relaxing 'Zen Den' room with soft lighting and calming scents, and short music therapy sessions. About 300 employees and students at Penn State Health will try these options and rep…

This study will test a behavioral program to improve sleep and daily rhythms in autistic teenagers aged 13-17 who have sleep problems. The goal is to see if the program is practical and helps teens sleep better, which may also improve their mood and thinking. The study involves 1…

This early-phase study tests whether taking vitamin B6 for up to 31 days can reduce the sharp rise in blood pressure that happens during exercise after a temporary lack of blood flow (like a leg injury). Researchers will measure blood pressure, heart rate, nerve activity, and wal…

This study tests a behavioral program called TranS-C to help autistic adults with sleep and circadian problems. The program teaches regular sleep routines, daytime habits, and helpful sleep beliefs. Researchers will enroll 24 autistic adults to see if the treatment improves overa…

This study looks at how changing the temperature and liquid in e-cigarettes affects the amount of harmful chemicals (oxidants) users breathe in. Researchers will measure markers of cell damage in breath, cheek cells, and blood from 50 adult e-cigarette users. The goal is to under…

This study explores whether a culturally adapted conversation game, called the Hello game, can help members of the Washoe Tribe engage in advance care planning (ACP). Researchers will first hold talking circles to understand tribal beliefs and then test the game in group settings…

This study looks at how the loss of estrogen after menopause may raise the risk of heart problems by increasing blood pressure, nerve activity, and inflammation. Researchers will measure these factors in 20 healthy postmenopausal women aged 54-75. The goal is to better understand…