Children's Hospital Medical Center, Cincinnati

This study aimed to measure how well the Rotarix vaccine prevents severe rotavirus infections in young children. Researchers compared children hospitalized or visiting the emergency room with rotavirus (cases) to similar children without rotavirus (controls). They looked at vacci…

This study tested a smartphone-based support program designed to help teenagers with moderate to severe asthma remember to take their daily controller medications. 72 teens aged 12-18 used a special inhaler cap that tracked their doses and received reminders and coaching via text…

This study tested whether personalized coaching could help teenagers and young adults with cancer take their oral medications as prescribed. Researchers compared a tailored coaching program against standard weekly feedback messages. The goal was to see if the coaching approach wa…

This study tested a telehealth support program called GET2HOME for children with complex chronic conditions and their families after hospital discharge. The goal was to see if virtual check-ins and support could help these children avoid urgent return visits to the hospital or em…

This study aimed to find the best dose of the antibiotic ceftaroline for children and teens with cystic fibrosis who have a history of a specific hard-to-treat lung infection (MRSA). Researchers measured how the drug moved through the bodies of 8 young patients to see if standard…

This study tested if a drug called tofacitinib, which is used for arthritis, could help control moderate to severe skin rashes caused by lupus. It involved 13 young adults and primarily aimed to see if the drug was safe and how it behaved in their bodies over 76 weeks. The resear…

This study tested whether a quick, non-invasive brain stimulation technique could improve the brain's ability to control unwanted movements in people with Tourette Syndrome. Researchers worked with 16 children and teens, using a special magnetic pulse on a specific brain area tho…

This study tested a smartphone-based program to help children with epilepsy take their medication more consistently. It involved 268 children, aged 2-12, who were newly diagnosed. The program provided families with education, digital reminders, and personalized feedback to help t…

This small, early-stage study tested a new combination of three treatments—an immunotherapy drug, a chemotherapy drug, and targeted radiation—in children and young adults (ages 1-40) whose cancers had returned or stopped responding to standard treatments. The main goals were to s…

This study tested if a special sugar called 2'-fucosyllactose (2FL), given as an oral supplement, could help protect the gut in children and young adults receiving a bone marrow transplant. The goal was to see if the supplement could reduce harmful gut bacteria, lower inflammatio…

This study tested whether dupilumab, an injectable medication, could reduce harmful inflammation in the stomachs of people with eosinophilic gastritis. Forty-one participants aged 12-70 received either the drug or a placebo injection every two weeks for 12 weeks. The main goal wa…

This study tested a new type of MRI scan using a special gas to see if it can detect early signs of a serious complication called BOS in people who have had a lung transplant. BOS is a form of chronic rejection that affects over half of transplant recipients who survive five year…

This study aimed to find the best and most affordable way to screen teenagers for gonorrhea and chlamydia when they visit a pediatric emergency room. Researchers tested two methods across a national network of hospitals: one that offered testing to all teens and another that targ…

This study tested whether the timing of extra sleep affects what teenagers eat. Researchers worked with 190 healthy teens, comparing 'Morning Larks' and 'Night Owls,' to see if aligning longer sleep with their natural body clock reduces calorie intake and unhealthy foods. The goa…

This study tested a family-focused program designed to prevent childhood obesity. It worked with mothers in the first year after weight loss surgery and their children aged 6-12 who were at risk for obesity. The program taught healthy eating and activity habits for the whole fami…

This small pilot study tested whether custom 3D-printed masks could make sleep apnea treatment more comfortable for children. Researchers scanned children's faces to create perfectly fitted masks for their CPAP machines. The study measured if the custom masks were used more often…

This study tested a virtual group program called 'Tuning in to Kids' for parents of young children with congenital heart disease. The program taught parents skills to help their children understand and manage emotions, aiming to improve the children's emotional and behavioral wel…

This small, early-stage study tested a new toothpaste containing the medication tacrolimus. It was given to a few children and young adults who developed painful mouth sores after a stem cell transplant, a condition called oral graft-versus-host disease. The goal was to see if ap…

This was a small, completed pilot study to gather information for designing a future, larger trial. It tested a method to see which premature babies with a chronic lung disease (BPD) have a short-term positive response to a water pill called furosemide. The study also checked if …

This large international study aimed to better understand and predict acute kidney injury (AKI) in children who are critically ill. Researchers observed over 5,000 children in intensive care units worldwide to see if a scoring system called 'renal angina' and certain urine tests …

This study tested a new MRI technique to take clearer pictures of lungs without using radiation. Researchers compared images from healthy people and those with lung diseases to understand differences. The goal was to develop better imaging methods that could eventually help docto…

This study tested a new way to train emergency medical workers on life-saving procedures for children. Instead of bringing in outside experts, local trainers used head-mounted cameras to record themselves practicing. Remote pediatric experts then watched the videos and gave feedb…