Children's Hospital Medical Center, Cincinnati

This pilot study tests whether a cream containing ruxolitinib, a drug that blocks certain immune signals, is safe and helpful for people who develop acute skin graft-versus-host disease (GVHD) after a stem cell transplant. Participants aged 2 to 35 with a malignancy and skin GVHD…

This pilot study tests whether putting back a child's own thymus tissue during heart surgery is safe and helps support the immune system. In some congenital heart disease surgeries, the thymus is removed to reach the heart, which may weaken immunity. Researchers will compare chil…

This trial investigates whether semaglutide, a medication used for diabetes and obesity, can help adolescents aged 12-18 with autism spectrum disorder (ASD) and obesity reduce their body mass index (BMI). Participants will receive either semaglutide injections or lifestyle counse…

This study tests whether community health workers (CHWs) can help people with rheumatic heart disease (RHD) take their monthly antibiotic shots consistently. The trial will enroll about 308 participants in Brazil and Timor-Leste, including adults and children with RHD and their c…

This study tests whether text-message reminders and coaching can help 389 teens (ages 12-18) with moderate to severe asthma take their daily inhaled steroids as prescribed. Participants will be split into three groups: one gets a basic asthma app, another adds personalized text r…

This early study tests whether semaglutide, a drug already used for type 2 diabetes, can protect the body's insulin-producing cells in people with stage 1 type 1 diabetes. The goal is to see if it can delay or prevent the disease from progressing to the next stage. Fifteen adults…

This study tests whether an AI tool called RADAR can help nurses in low-resource settings detect rheumatic heart disease more accurately using echocardiography. The goal is to make screening easier to scale up worldwide. The trial will enroll 62 nurse screeners at participating f…

This trial tests whether giving children aged 5 to 8 a twice-daily penicillin pill can prevent rheumatic heart disease, a serious condition that can damage heart valves. Researchers will compare children who take the antibiotic with those who do not, following them for three year…

This study follows 7,500 children aged 5 to 8 who live in areas where rheumatic heart disease is common. Each child gets a heart ultrasound once a year for three years to check for early signs of the disease. Researchers will count how many children develop rheumatic heart diseas…

This observational study aims to understand how daily factors like food intake and medication adherence affect the levels of immunosuppressant drugs (tacrolimus and mycophenolate) in children who have received a kidney transplant. By tracking drug exposure over a year, researcher…

This study tests a cloud-based tool called ACT+ to help people in Uganda get follow-up care after a positive screening for rheumatic heart disease. Researchers will work with local providers to improve the tool and then see if it increases the number of people who complete a conf…

This study tests a virtual reality training program for pediatric doctors and nurses. The goal is to help them learn how to talk with parents about safely storing firearms at home. Thirty clinicians will complete the training and provide feedback on how useful and practical it is…