Children's Hospital Medical Center, Cincinnati

This study tests whether adding sodium thiosulfate, with or without the drug vorinostat, can protect hearing when children and young adults with relapsed cancers need cisplatin chemotherapy again. It focuses on patients with specific childhood cancers like hepatoblastoma, Wilms t…

This study is developing and testing a program called I2-ART, which uses trained 'family navigators' to help Latinx and African American families follow through with ADHD treatments for their children. The goal is to improve how consistently kids receive recommended medications o…

This study is testing if adding the drug ruxolitinib to standard steroid treatment can reverse early signs of lung damage in children and adults who have had a stem cell transplant. The goal is to stop the progression to a severe, often fatal lung condition called bronchiolitis o…

This study is testing whether specially designed immune cells, grown from a patient's own blood, can safely and effectively fight serious viral infections that occur after organ transplants. It involves 42 children and adults who have developed specific viral infections after rec…

This study is testing single doses of three existing medications—baclofen, roflumilast, and memantine—to see if they can improve brain activity and behavior in adults with Fragile X Syndrome. Researchers will measure changes in brain waves and ask caregivers about symptoms after …

This study is testing whether weight-loss surgery is better than intensive medical therapy for long-term blood sugar control in teenagers with type 2 diabetes. It will involve about 90 teens, comparing the effects of a specific surgery (vertical sleeve gastrectomy) against the be…

This study is testing if providing monthly grocery gift cards to low-income families for one year helps children recover better after leaving the hospital. Researchers want to see if this support reduces families' struggles to afford food and lowers the child's need for unplanned…

This program provides expanded access to the medication stiripentol for patients with Dravet syndrome, a rare and severe form of childhood epilepsy. It allows patients aged 6 months and older who have hard-to-control seizures to receive this treatment outside of regular clinical …

This study aimed to test a new method for predicting which critically ill children and newborns are most likely to develop serious kidney injury. Researchers planned to use a urine test (NGAL) and a risk-scoring tool to identify at-risk patients earlier. The goal was to help doct…

This study aims to create a simple screening tool to identify cerebral vision impairment (CVI) in infants as young as 4-12 months old. Researchers will enroll 600 children, including those at risk for CVI and those with a confirmed diagnosis, to test various vision and developmen…

This study is testing a new three-part tool to help doctors better predict which critically ill children are most likely to develop serious kidney injury. The tool combines a risk score, a urine test, and a simple medication challenge. The goal is to identify kids who will need d…

This study is testing a new computer modeling tool to help doctors predict whether surgery will successfully treat obstructive sleep apnea in children and young adults with Down Syndrome. Researchers will use MRI scans taken during sleep to create personalized computer models of …

This study aimed to use advanced brain scanning to find the exact spots in the brain that cause seizures in people with hard-to-treat epilepsy. The goal was to create a better, non-invasive map to guide surgeons, potentially helping more people become seizure-free after surgery. …

This study aims to find out if taking penicillin by mouth twice daily is as effective as getting a monthly penicillin injection at preventing latent rheumatic heart disease from getting worse. It involves about 1,000 children and teenagers, aged 5 to 17, who have been diagnosed w…

This study compares two behavioral programs designed to help children with autism better manage their emotions and daily routines. 144 children ages 8-12 will participate in either an emotion regulation program or a school skills program, attending sessions twice a week for 5 wee…

This study is testing whether a special communication technology can help deaf or hard-of-hearing children improve their language skills. It involves 114 children aged 3 to 10 who already receive speech therapy. The children are randomly assigned to either use the new technology …

This study is testing whether adding special communication technology to regular speech therapy helps children who are deaf or hard of hearing develop better language skills. About 150 children with hearing loss and a language gap are participating. Half will use the technology a…

This study is testing whether a non-invasive brain stimulation technique can help reduce depression in teens and young adults with autism. Researchers are comparing a real stimulation treatment to a fake (sham) treatment in 24 participants aged 13-26 who have both autism and depr…

This study aims to understand how a baby's first encounter with the flu—whether through infection or vaccination—shapes their immune system's response to future flu exposures. Researchers will follow 1,500 mother-infant pairs from pregnancy through early childhood, tracking illne…

This study aims to understand the genetic causes of congenital heart defects (CHD), which are common and serious birth abnormalities. Researchers are collecting DNA samples and detailed health information from 32,000 participants, including children with CHD and their families. T…

This study aims to understand how cystic fibrosis affects the small blood vessels in the lungs. Researchers will compare lung scans from 86 children and young adults with cystic fibrosis to scans from people without lung disease. They will also track changes in some participants …

This study aims to collect information on how a specialized dialysis machine (CARPEDIEM) works for critically ill infants with severe kidney problems. Researchers will observe about 1000 infants across multiple hospitals who are already receiving this treatment as part of their s…

This study aims to see if special MRI scans can help doctors better understand and predict complications from pancreatitis in children. Researchers will compare MRI results with other tests to see if the scans can spot early signs of diabetes or digestive problems. The goal is to…

This study aims to create a better, standardized way to use a special type of MRI scan to see how interstitial lung disease (ILD) changes over time or responds to treatment. Participants will breathe in a safe, non-radioactive gas (xenon) during the scan, which helps create a det…

This study aims to understand how cystic fibrosis (CF) affects blood flow in the lungs. Researchers are using a new, safe MRI method that doesn't require injection dye to map blood flow in children with CF. They will compare these blood flow maps to breathing tests and blood mark…

This study aims to understand why some children experience more pain, side effects, or long-term discomfort after major spine surgery. Researchers are following 880 adolescents to see if their genes, stress levels, or other personal factors can predict their recovery. The goal is…

This study aims to understand if a type of childhood liver disease, which blocks bile flow, makes red blood cells weaker or less flexible. Researchers will compare blood samples from about 20 children with the liver disease to 20 healthy children. The goal is to gather knowledge …

This study is creating a registry to collect medical information, tissue samples, and images from people with a rare type of kidney cancer called TFE Renal Cell Carcinoma. The goal is to gather data to help scientists understand the biology of this cancer better. This knowledge i…

This study is testing a special, radiation-free MRI scan that uses a safe inhaled gas to create detailed pictures of the lungs. The goal is to see if this scan can detect very early changes in lung health in children with cystic fibrosis, especially as they start new, highly effe…