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New MRI study aims to spot pancreas trouble early

NCT ID NCT05659147

Knowledge-focused Sponsor: Children's Hospital Medical Center, Cincinnati Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing whether MRI scans can help predict pancreas health and complications like diabetes in children and young adults aged 5 to 21. Researchers will compare MRI images with standard tests like endoscopic pancreas function tests and blood work. The goal is to see if MRI can replace more invasive procedures and catch problems earlier.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could lead to a non-invasive way to predict and monitor pancreatic disease and diabetes using MRI instead of more invasive tests.
What could go wrong
This is an observational imaging study, not a treatment trial. It may not find clear links between MRI results and disease outcomes, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 195 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2023

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

5 to 21 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Aim 1- Patient Group: Inclusion Criteria: * Age 5 to \<21 years * Scheduled for clinically-indicated gastrointestinal endoscopy * Clinical diagnosis or suspicion of exocrine pancreatic insufficiency Exclusion Criteria: * Complete fatty replacement of pancreas on prior imaging * Current acute pancreatitis or acute pancreatitis less than 30 days prior to research MRI * Need for sedation for MRI * Contraindication to MRI (implanted metal hardware) * Allergy to secretin * Pregnancy Control Group: Inclusion Criteria: * Age 5 to \<21 years * Scheduled for clinically-indicated gastrointestinal endoscopy Exclusion Criteria: * Sweat chloride \>60 mmol/L * Clinical diagnosis of gastrointestinal pathology * Clinical diagnosis or history of pancreatic disease * Complete fatty replacement of pancreas on prior imaging * Current acute pancreatitis or acute pancreatitis less than 30 days prior to research MRI * Need for sedation for MRI * Contraindication to MRI (implanted metal hardware) * Allergy to secretin * Pregnancy Aim 2- Acute Pancreatitis Group: Inclusion Criteria: * Age 5 to \<21 years * Clinically documented episode of acute pancreatitis Exclusion Criteria: * More than one episode of acute pancreatitis * Current acute pancreatitis or acute pancreatitis less than 30 days prior to research MRI * Need for sedation for MRI * Contraindication to MRI (implanted metal hardware) * Pregnancy Acute Recurrent Pancreatitis Group: Inclusion Criteria: * Age 5 to \<21 years * Clinical diagnosis of acute recurrent pancreatitis Exclusion Criteria: * Current acute pancreatitis or acute pancreatitis less than 30 days prior to research MRI * Need for sedation for MRI * Contraindication to MRI (implanted metal hardware) * Pregnancy Pancreatitis-Related Diabetes Group: Inclusion Criteria: * Age 5 to \<21 years * Clinical diagnosis of pancreatitis-related diabetes Exclusion Criteria: * Current acute pancreatitis or acute pancreatitis less than 30 days prior to research MRI * Need for sedation for MRI * Contraindication to MRI (implanted metal hardware) * Pregnancy Aim 3- Control Group: Inclusion Criteria: • Age 5 to \<21 years Exclusion Criteria: * Sweat chloride \>60 mmol/L * Clinical diagnosis of gastrointestinal pathology * Clinical diagnosis or history of pancreatic disease, including acute pancreatitis * Need for sedation for MRI * Contraindication to MRI (implanted metal hardware) * Allergy to secretin * Pregnancy Acute Pancreatitis Group: Inclusion Criteria: * Age 5 to \<21 years * Clinically documented episode of acute pancreatitis Exclusion Criteria: * More than one episode of acute pancreatitis * Current acute pancreatitis or acute pancreatitis less than 30 days prior to research MRI * Need for sedation for MRI * Contraindication to MRI (implanted metal hardware) * Allergy to secretin * Pregnancy Acute Recurrent Pancreatitis Group: Inclusion Criteria: * Age 5 to \<21 years * Clinical diagnosis of acute recurrent pancreatitis with no evidence of CP or EPI Exclusion Criteria: * Current acute pancreatitis or acute pancreatitis less than 30 days prior to research MRI * Need for sedation for MRI * Contraindication to MRI (implanted metal hardware) * Allergy to secretin * Pregnancy Chronic Pancreatitis Group: Inclusion Criteria: * Age 5 to \<21 years * Clinical diagnosis of chronic pancreatitis Exclusion Criteria: * Current acute pancreatitis or acute pancreatitis less than 30 days prior to research MRI * Need for sedation for MRI * Contraindication to MRI (implanted metal hardware) * Allergy to secretin * Pregnancy Aim 4- Inclusion Criteria: * Age 5 to \<21 years * Completed research MRI under Aims 1 or 3 of this study Exclusion Criteria: * Failed/unable to complete first research MRI under Aims 1 or 3 * Episode of acute pancreatitis since first research MRI * Current acute pancreatitis * Any gastrointestinal surgery or pancreas intervention (e.g. ERCP) since first research MRI * Need for sedation for MRI * Contraindication to MRI (implanted metal hardware) * Allergy to secretin * Pregnancy Aim 5- Inclusion Criteria: • MRI performed at CCHMC Exclusion Criteria: * Severe image artifact compromising image quality (judgement of study team) * Age \>21 years

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Conditions

The condition(s) this trial relates to.

acute pancreatitis chronic pancreatitis diabetes mellitus exocrine pancreatic insufficiency pancreatitis recurrent acute pancreatitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Diabetes mellitus Pancreatitis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Cincinnati Children's Hospital Medical Center

    Cincinnati, Ohio, 45229, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.