Can a single dose ease fragile x? new trial tests three drugs

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Subjects ages 18-45, with FXS who completed the study entitled "Mechanisms and brain circuits underlying fragile X syndrome" (IRB # 2015-8425) or appropriate baseline measures through Biorepository (2013-7327). * FXS is defined as full FMR1 mutations (\>200 CGG repeats) confirmed by genetic testing. * General good health as determined by physical exam, medical history and laboratory work up. * Stanford Binet IQ \<85 * Stable dosing of psychotropic drugs for at least 4 weeks. Exclusion Criteria: * Subjects with a history of intolerance to baclofen, roflumilast, or memantine will be excluded. * Subjects will also be excluded if they have taken any investigational drug within 3 months, have a history of substance abuse or dependence within 6 months, or significant psychiatric or CNS neurological disease unrelated to FXS. * Uncontrolled seizures or history of epilepsy with a seizure in the past 6 months * Auditory or visual impairments that cannot be corrected based on visual and auditory screener benchmarks. * Moderate to severe renal or hepatic impairment and determined by a study physician incorporating data from exam, medical history and laboratory value evaluation among other data points. * Use of barbiturates, benzodiazepines, antiepileptics, or other GABAergic or glutamatergic modulators * Current use of: Amifampridine, Butalbital, Codeine, Doxylamine, Ethanol, Hydrocodone, Isocarboxazid, Kava, Metoclopramide, Midazolam, Oxybate, Phenelzine, Promethazine, Thalidomide, Tranylcypromine, Trimethobenzamide, Erythromycin, Ketoconazole, Fluvoxamine, Enoxacin, and Cimetidine. * Those taking other psychiatric medications must be on stable doses for 4 weeks before the baseline visit. * Pregnancy or breast-feeding. For female subjects of child bearing potential, a urine pregnancy test will be performed. * Potential subjects with a creatinine clearance \< 50 mL/min will be excluded. * Identified medical issues, inability to tolerate study procedures or study drug per the discretion of the Principal Investigator.