Can a single dose ease fragile x? new trial tests three drugs
NCT ID NCT05418049
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a single dose of baclofen, roflumilast, or memantine can improve brain activity and symptoms in adults with Fragile X syndrome. Forty-five participants aged 18 to 45 will receive each drug or a placebo in separate sessions. The main goal is to measure changes in brain waves using EEG, along with clinician and caregiver ratings of improvement.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
baclofen, roflumilast, memantine
What this could lead to
If successful, this could point toward a short-term treatment to ease certain symptoms of Fragile X syndrome.
What could go wrong
This is an early phase 2 trial with only 45 participants, testing single doses. It may not show clear benefits, and results may not apply to long-term use.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, 45229, United States