New MRI technique could reveal how well lung treatments are working
NCT ID NCT06012500
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study is testing a special MRI technique using inhaled xenon gas to better see changes in the lungs of people with interstitial lung disease. Researchers want to make the method consistent across different hospitals and MRI machines. The goal is to help doctors quickly tell if a treatment is working, without invasive procedures.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Xenon-129 (inhaled contrast for MRI)
- What this could lead to
- If successful, this could make 129Xe MRI a reliable tool to see how well lung treatments are working, helping doctors personalize care for interstitial lung disease.
- What could go wrong
- This is an early-phase study focused on imaging methods, not a treatment. It may not lead to direct patient benefits, and results may vary across different MRI machines.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 1/2
Runs two stages together: safety and dose first, then whether the treatment works.
- Participants
-
78 people
The number who actually took part.
- Started
-
Apr 2022
- Expected to finish
-
Dec 2027
An estimate. End dates often move.
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 90 years
- Sex
-
Anyone
- Healthy volunteers
-
Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Outpatients age 18 - 90 years old. 2. Subject has no diagnosed pulmonary conditions 3. Subject has not smoked in the previous 5 years 4. Smoking history, if any, is less than or equal to 5 pack-years Additional inclusion criteria for menstruation sub-study in healthy volunteers 1. Subject has a regular 26-30-day menstrual cycle 2. Subject is taking prescribed hormonal contraceptives that preserve a regular menstrual cycle. Exclusion Criteria: 1. MRI is contraindicated based on responses to MRI screening questionnaire 2. Subject is pregnant or lactating 3. Resting oxygen saturation on room air \<90% 4. Respiratory illness of a bacterial or viral etiology within 30 days of MRI 5. Subject has history of any known severe ventricular cardiac arrhythmia, as determined by the study physician. 6. Subject has history of cardiac arrest within the last year 7. Subject cannot hold their breath for 16 seconds
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, 45229, United States
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