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Do blood thinners help or hurt when cancer meets a clot?

NCT ID NCT07748234

Knowledge-focused Sponsor: Children's Hospital Medical Center, Cincinnati Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 05, 2026 · Last updated Aug 06, 2026 · Updated 1 time

Summary

This study looks back at medical records of children and young adults with solid tumors or lymphoma who also have a tumor thrombus—a blood clot that forms in a vein due to tumor pressure or invasion. Researchers will gather data on who received blood thinners or procedures like stents, and track outcomes such as bleeding, clot growth, and survival. The goal is to better understand how these clots are managed and what approaches may be safest.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
This could clarify whether blood thinners help or harm people with tumor-related blood clots, guiding safer treatment decisions.
What could go wrong
Because this is a retrospective review, it can only show associations, not proof. Results may be limited by incomplete records or varied treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 1,900 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2026

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

All individuals evaluated by Cincinnati Children's Hospital Medical Center Oncology program with a diagnosis of solid tumor and lymphoma (including osteosarcoma, Ewing sarcoma, Wilms tumor, hepatoblastoma, neuroblastoma, Hodgkin's and non-Hodgkin's lymphoma) since the initiation of EPIC medical record at CCHMC January 01, 2010 - January 01, 2026, and who are identified radiographically as having thrombus will have further review to determine if they have tumor thrombus or vascular compression for cohort inclusion.

Ages

0 months to 40 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: All Cincinnati Children's Hospital Medical Center (CCHMC) Oncology patients in the cancer registries (ACCRN07 CCHMC IRB #2008-1609 and the COG Registry CCHMC IRB # 2019-0616) identified as having a solid tumor and lymphoma (including osteosarcoma, Ewing sarcoma, Wilms tumor, hepatoblastoma, neuroblastoma, Hodgkin's and non-Hodgkin's lymphoma) diagnosis, and who, on review of radiographic study reports, have mention of tumor thrombus or vascular compression since January 01, 2010 - January 01, 2026, between the ages of 0 and 40 years old. Exclusion Criteria: Cancer diagnosis other than a lymphoma or solid tumor Absence of tumor thrombus or vascular compression mentioned in radiographic reports stored at CCHMC (EPIC © 2020 Epic Systems Corporation). Lack of medical records available at CCHMC for review

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Conditions

The condition(s) this trial relates to.

lymphoma neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Tumor thrombus

Contacts and locations

Locations

  • Cincinnati Children's Hospital Medical Center

    Cincinnati, Ohio, 45229, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.