Small study paves way for smarter diuretic use in preemie lungs

NCT ID NCT05898022

Completed Knowledge-focused Sponsor: Children's Hospital Medical Center, Cincinnati Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 01, 2026 · Updated 29 times

Summary

This study looked at 19 premature babies with a chronic lung condition called bronchopulmonary dysplasia (BPD). Doctors often use diuretics (water pills) to help these babies breathe, but it's unclear who truly benefits. The researchers tested a personalized approach called an N-of-1 trial, where each baby was switched between the diuretic and a placebo to see if they responded. The goal was to learn how to design a larger, more definitive study on diuretic use for BPD.

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Contacts and locations

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Locations

Case Western Reserve University, Rainbow Babies and Children's Hospital

Cleveland, Ohio, 44106, United States
Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, 45229, United States
Emory University

Atlanta, Georgia, 30303, United States
RTI International

Durham, North Carolina, 27705, United States

Conditions

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BRONCHOPULMONARY DYSPLASIA