BRONCHOPULMONARY DYSPLASIA

This study is testing the safety of an inhaled steroid called ciclesonide in premature infants who are at high risk for developing a serious chronic lung condition called bronchopulmonary dysplasia (BPD). The goal is to see if this medication, which is already approved for asthma…

This study compares two different non-invasive breathing support methods for extremely premature infants who are being taken off mechanical ventilators. Researchers want to see if a newer technology called NIV-NAVA, which syncs with the baby's own breathing efforts, works better …

This study aims to find the best oxygen level for premature babies who have developed a severe chronic lung disease (bronchopulmonary dysplasia) and high blood pressure in their lungs (pulmonary hypertension). Doctors will test two different oxygen level targets in 39 infants to …

This study is testing whether giving intravenous immunoglobulin (IVIG), a solution of antibodies, can help treat a serious lung condition called bronchopulmonary dysplasia in very premature babies. It will involve about 20 infants born between 25 and 30 weeks of pregnancy who sho…

This study is testing whether a new drug called zelpultide alfa can prevent bronchopulmonary dysplasia (BPD), a serious lung condition, in extremely premature babies. The trial will involve 366 infants born between 22 and 28 weeks of pregnancy who are on breathing machines. Babie…

This study is testing whether an investigational drug called OHB-607 can prevent a serious lung condition called bronchopulmonary dysplasia (BPD) in extremely premature infants. It will compare the drug to standard neonatal care alone in about 338 babies born between 23 and 28 we…

This study is testing a new, non-invasive device that measures lung function in premature infants with bronchopulmonary dysplasia (BPD) while they sleep normally. Researchers want to see if this device can provide useful information about how these babies' lungs are working, whic…

This study aims to better understand how lungs grow and develop in premature babies, especially those with a breathing disorder called BPD. Researchers will use MRI scans (up to three times) on 160 babies in the NICU to take detailed pictures of their lungs and airways. The goal …

This study is testing a new, radiation-free imaging system called EIT to see how well it can show lung function in people with breathing problems. Researchers will use it on children and adults with conditions like chronic lung disease or muscle weakness, as well as healthy volun…

This study is testing a special pressure-sensing mattress to see if it can accurately monitor breathing and heart rate in premature babies who need breathing machine support. Researchers will enroll 60 babies in the neonatal intensive care unit to compare the mattress sensor read…

This study aims to understand how doctors decide when to remove breathing tubes from extremely premature babies and why some babies need the tube put back in. Researchers will observe 100 babies born before 28 weeks and record doctors' daily decisions about breathing support duri…