BRONCHOPULMONARY DYSPLASIA

This study tests whether intravenous immunoglobulin (IVIG) can help preterm babies with bronchopulmonary dysplasia (BPD), a serious lung condition. Twenty infants born between 25 and 30 weeks will receive IVIG infusions over 5 days. The main goal is to see if more babies survive …

This study tests whether a medicine called IVIG can help very premature babies (born at 28 weeks or earlier) who are at risk for a serious lung condition called bronchopulmonary dysplasia (BPD). About 29 babies will receive IVIG through a vein for several days. Researchers will c…

This study tests a new type of breathing support (NIV-NAVA) for very premature babies (born at 23-28 weeks) who are being taken off a ventilator. The goal is to see if this smarter, baby-triggered support reduces the chance of needing to go back on the ventilator within 5 days, c…

This study compares two types of intravenous fat emulsions (mixed oil vs. soybean oil) in extremely preterm infants (born before 28 weeks or weighing ≤1000g). The goal is to see which one better prevents a serious lung condition called bronchopulmonary dysplasia and supports norm…

This study looks at whether different oxygen levels can help preterm infants who have both a chronic lung disease (bronchopulmonary dysplasia) and high blood pressure in the lungs (pulmonary hypertension). About 39 infants born extremely early will be enrolled. Researchers will m…

This study tests an investigational drug called OHB-607 to see if it can prevent bronchopulmonary dysplasia (BPD), a serious chronic lung disease, in extremely premature infants. About 338 babies will be randomly assigned to receive either the drug or standard care. The goal is t…

This study tests whether giving slightly less fluid (135 mL per kg per day) compared to standard amounts (165 mL per kg per day) can prevent a serious lung condition called bronchopulmonary dysplasia (BPD) in very premature babies born before 30 weeks. About 750 infants will take…

This study tests an investigational drug, zelpultide alfa, to see if it can prevent a serious lung condition called bronchopulmonary dysplasia (BPD) in extremely premature babies (born as early as 22 weeks). About 366 high-risk infants who are on breathing machines will receive e…

This early-phase study tests whether an inhaled steroid called ciclesonide is safe for preterm infants (born between 23 and 30 weeks) who are on breathing machines and at risk for a chronic lung condition called bronchopulmonary dysplasia. About 30 babies will receive the drug, a…

This study watches how doctors decide when to remove breathing tubes (extubation) in extremely preterm babies (born before 28 weeks) during their first two weeks of life. Researchers will ask doctors daily why they choose to keep or remove the tube, and track whether the baby sta…

This study aims to measure lung function in premature infants with bronchopulmonary dysplasia (BPD) and healthy term infants using a technique called forced oscillometry. Researchers will compare baseline measurements and, in some cases, measure changes after bronchodilator thera…

This study tests whether a pressure-sensing mattress can accurately monitor breathing and heart rate in 60 newborns who need breathing support. The goal is to see if this non-invasive method could help doctors decide when to safely remove a breathing tube. The research focuses on…

This study tests a new imaging device called Electrical Impedance Tomography (EIT) that uses electrodes to create lung pictures without radiation. Researchers will compare EIT images to standard tests in children with chronic lung disease, neuromuscular disease, and healthy contr…

This study looks at how to set the breathing machine (ventilator) for very premature babies (born before 34 weeks) who need help breathing. Researchers will test different pressure levels to see which one helps the heart pump blood best and improves oxygen levels. They will use s…

This study uses MRI scans to learn how the lungs grow and develop in both full-term and extremely preterm babies, especially those with a breathing problem called bronchopulmonary dysplasia (BPD). Researchers want to better understand how prematurity affects lung structure and fu…

This study looks at how certain medicines act in the bodies of children and young adults under 21. Researchers want to find the safest and most effective doses for these age groups. Participants are already receiving these drugs as part of their normal care. No new treatments are…