Children's Hospital Medical Center, Cincinnati

This early-phase trial tests whether a combination of three drugs (inotuzumab ozogamicin, venetoclax, and dexamethasone) is safe for people whose B-cell acute lymphoblastic leukemia has returned. About 28 children and adults will receive the treatment over one or two 28-day cycle…

This study tests whether Zemaira, a drug that blocks certain enzymes, can help adults with eosinophilic esophagitis (EoE), a condition where immune cells build up in the esophagus and cause trouble swallowing. Fifteen participants will receive Zemaira infusions weekly for 4 weeks…

This early-stage study tests the safety of combining two drugs, venetoclax and Vyxeos, in children, teens, and young adults (ages 1 to 39) with acute leukemia that has come back or not responded to prior therapy. The goal is to find a safe dose and see if the combination helps co…

This study aims to improve how hydroxyurea is dosed for people with sickle cell anemia. Instead of using only weight, the new method considers how each person absorbs the drug. Researchers hope this will reduce damage to the brain, kidneys, heart, and spleen. The study enrolls 50…

This early study tests whether giving zoledronate soon after a stem cell transplant can safely prevent bone loss and fractures in children. About 20 children aged 5 to 18 who are at high risk for bone problems will receive the drug. The main goals are to check safety and see if i…

This study tests whether specially trained immune cells from a half-matched donor can safely treat acute myeloid leukemia (AML) that has come back or not responded to standard treatment. About 20 people aged 2 and older will receive an infusion of these cells. The goal is to see …

This study tests a new gene therapy for hereditary pulmonary alveolar proteinosis (hPAP), a rare lung disease that makes breathing difficult. Doctors will take a patient's own lung cells, fix a faulty gene, and transplant them back into the lungs. Only 3 adults with confirmed hPA…

This study tests whether a simple xylitol wipe applied inside the mouth twice a day can reduce dangerous bloodstream infections in children receiving stem cell transplants. These infections often start from mouth bacteria and can be life-threatening. The trial involves 419 childr…

This study tests whether specially grown immune cells from a donor can safely treat viral infections that often occur after a stem cell transplant. These infections can be serious and sometimes don't respond to standard medicines. The approach aims to boost the patient's weakened…

This study tests a drug called mirdametinib in people aged 2 and older with certain rare immune cell diseases (like Langerhans cell histiocytosis). The goal is to see if it works better and causes fewer side effects than current treatments. About 40 participants will take the dru…

This study tests a procedure called FETO (fetal endoscopic tracheal occlusion) in pregnant women whose babies have a severe form of congenital diaphragmatic hernia (CDH), where the diaphragm has a hole and the lungs are too small. The surgery places a tiny balloon in the baby's w…

This study tests a stem cell transplant method for people with Fanconi anemia who don't have a perfectly matched donor. The goal is to see if using lower doses of certain chemotherapy drugs can reduce serious side effects while still helping the transplant succeed. About 70 parti…

This study tests whether romiplostim, a drug that helps the body make more platelets, can prevent dangerously low platelet counts caused by chemotherapy in children and young adults with newly diagnosed Ewing sarcoma. About 26 participants will receive romiplostim alongside their…

This study tests whether specially trained immune cells from a healthy donor can safely treat viral infections in people whose immune systems are weak, such as after a stem cell transplant. The cells are grown in a lab and then given to the patient. The main goals are to see if t…

This early-stage study tests whether quercetin, a natural antioxidant found in foods, is safe and can reduce inflammation in male patients with XIAP deficiency, a rare genetic immune disorder. The trial will enroll 12 participants aged 2 and older. Researchers will monitor side e…

This study tests a group training program for foster and kinship caregivers to help prevent behavior problems in young children (ages 2-9) in foster care. About 300 caregivers in Ohio will be randomly assigned to either the training program or standard support. The goal is to see…

This study tests whether adding a daily pill (amitriptyline) to online cognitive behavioral therapy (CBT) helps prevent migraines in children better than online CBT alone. About 400 kids with frequent migraines will participate. The goal is to see which approach reduces headache …

This study tests an online program called "Survivors Journey" that teaches problem-solving and coping skills to teens and young adults (ages 15-25) who have survived a pediatric brain tumor. The program also involves their caregivers. The goal is to see if the program is easy to …

This study tests a nurse-led mind-body program to reduce headache days in children with migraine. 260 kids with migraine will try different combinations of three treatment parts to find the best approach. The goal is to see if this program can lower the number of headache days an…

This study tests whether deep transcranial magnetic stimulation (dTMS) is safe and helpful for teenagers (ages 14-18) hospitalized with major depression and suicidal thoughts. Participants receive either real or sham dTMS alongside their usual care. The goal is to see if this non…

This study compares two group interventions for middle-school children with autism. One program teaches social skills, the other focuses on organization and planning. 224 kids will be randomly assigned to one of the two programs. The goal is to see which approach better improves …

This study tests a virtual reality driving program for teens aged 16-19 with ADHD who have a driver's license. The training focuses on reducing how often they look away from the road, which is a common cause of crashes. Participants will complete simulated drives while doing task…

This study looks at how the brain handles speech when there is background noise, in people with autism, Fragile X syndrome, and those without either condition. About 60 participants will complete hearing tests, questionnaires, and brain recording tasks. The goal is to understand …

This study looks at whether a condition called eosinophilic gastritis (EG) — a type of stomach inflammation — can slow down how the stomach empties food. Researchers will use a special scan after a meal to measure stomach movement in 30 people with EG. The goal is to better under…

This study aims to learn how eosinophils (a type of white blood cell) grow, move, and cause inflammation in people with eosinophilic gastrointestinal disease, other eosinophilic inflammatory diseases, or food allergies. Researchers will also look at family members and healthy vol…

This long-term study aims to understand how the sickle cell anemia medication hydroxyurea affects growth, puberty, and the ability to have children. Researchers will follow 250 young people with sickle cell anemia over time, comparing those who take hydroxyurea to those who don't…

This study creates a national registry for people with Pulmonary Alveolar Proteinosis (PAP), a rare lung disease. It aims to improve diagnosis, track how the disease progresses, and involve patients in planning future research. Up to 500 participants will provide data and samples…

This study compares a shorter, experimental MRI scan to the standard longer scan in 300 children and adults with Crohn's disease. The goal is to see if the quick version can detect bowel inflammation and other problems just as accurately. Participants will also share which scan t…

This study looks at how the body processes venetoclax when the tablet is crushed and mixed into a liquid for children and young adults with blood cancers like leukemia or lymphoma. About 30 participants who already take venetoclax this way will have blood samples taken to measure…

This study aims to create a computer tool that predicts which surgery will work best for children with obstructive sleep apnea (OSA). About 120 children with persistent OSA after tonsil and adenoid removal will undergo MRI scans to build detailed models of their airways. The tool…

This study tests a new type of PET scan to detect scarring in the lungs of people with tuberculosis (TB). Researchers will give 30 adults with active TB an injection of a special tracer and take whole-body images. The goal is to see if this scan can spot fibrosis (scarring) in TB…

This study uses MRI scans to learn how the lungs grow and develop in premature babies, especially those with a breathing problem called BPD. Researchers will look at lung structure and function in about 160 infants during quiet breathing. The goal is to better understand prematur…

This study is testing a special MRI technique that uses xenon gas to take detailed pictures of lung function. It involves 100 healthy adults who can hold their breath for 16 seconds. The goal is to improve how we see and measure lung activity, not to treat any disease.

This study is creating a large collection of blood samples and health information from 5,000 adults with congenital heart disease and related conditions. Researchers will use this data to better understand how these diseases work and what affects patient health. Participants prov…

This study looks at how the brain controls movement in children with dystonia, a condition that causes muscle spasms and twisting. Researchers will use noninvasive tests like EEG to measure brain activity in 75 children, both with and without deep brain stimulation devices. The g…

This study tests new ways to measure lung changes in people with cystic fibrosis (CF) aged 12 to 21. Researchers will use special MRI scans with a breathable gas (Xenon) and a lung function test called LCI to see what happens when patients stop and restart their daily airway clea…

This study compares two telehealth programs for autistic adolescents in their last two years of high school. One program focuses on daily living skills like cooking and managing money, while the other focuses on social skills. Researchers want to see which program better helps te…

This study is testing a new type of MRI that uses a special gas called xenon to take detailed pictures of lung function. Researchers want to see if this method works well in healthy people and those with lung diseases. About 300 children and adults ages 6 and older will participa…

This study is a registry that collects information from people with hemophagocytic lymphohistiocytosis (HLH), a rare condition where the immune system becomes overactive and damages the body. Researchers will track how the disease develops, what treatments are used, and how patie…

This study creates a repository of blood, tissue, and other samples from up to 5,000 children and adults with or at risk for pediatric heart disease. Researchers will use these samples to study how genes and health outcomes are linked. The goal is to support future research, not …

This study looks at whether infants and young children with sickle cell disease (SCD) get enough protection from the standard measles vaccine. Researchers will measure antibody levels in 130 children with SCD after they receive their routine measles shots. The goal is to understa…

This study looks at whether playing special sounds through headphones can help children aged 5-10 with Fragile X syndrome or autism. The sounds aim to calm overactive brain activity and improve learning. Researchers will measure brain waves and learning ability to see if the appr…

This study collects blood, tissue, and medical information from up to 1,000 people with RASopathies—a group of genetic conditions that affect development and raise cancer risk. Researchers will store these samples and data in a database to help future studies. No treatments or di…

This study aims to develop and validate a urine drug test that can detect thebaine, a substance found in poppy seeds. Researchers will enroll 20 healthy adults aged 18-65 to provide urine samples after eating poppy seed products. The goal is to create a more accurate screening me…