Children's Hospital Medical Center, Cincinnati

This study tests whether specially designed immune cells (VSTs) can safely treat viral infections in people who have had a solid organ transplant. About 42 participants will receive VSTs made from their own blood. The goal is to find a better way to fight infections without harmi…

This study tests the safety and effectiveness of hydroxyurea, a medicine that helps manage sickle cell disease, in 811 children aged 3 to 10 in Africa. The goal is to see if the drug can reduce complications and make it more widely available. Participants take hydroxyurea long-te…

This study looks at whether giving hydroxyurea based on a child's unique body chemistry can lower the need for blood transfusions in children with sickle cell anemia. About 100 children aged 1 to 10 years will receive the drug and be monitored. The goal is to make treatment more …

This study tests whether giving monthly grocery gift cards to low-income families for one year after their child's hospital discharge reduces food insecurity and the need to return to the hospital. About 400 families with Medicaid insurance will take part. Families in the interve…

This study tests whether a drug called sodium thiosulfate can prevent hearing loss in children and young adults (ages 1 month to 39 years) who are receiving cisplatin chemotherapy for relapsed or hard-to-treat liver tumors and other embryonal cancers. Participants will get cispla…

This study tests a program called Regulating Together, designed to help youth with autism spectrum disorder who have trouble managing their emotions. About 144 children and their caregivers will take part to see if the program improves emotional control and daily skills. The goal…

This study aims to find the genetic causes of congenital heart defects, the most common birth defect. Researchers will collect DNA and health information from 32,000 participants across multiple centers. The goal is to better understand why these heart problems occur and how gene…

This study aimed to create a database of high-frequency brain signals to better understand epilepsy, migraine, and other brain conditions. Researchers planned to use advanced software to analyze these signals in healthy volunteers aged 1 day to 69 years. However, the study was wi…

This study will develop a simple screening test to find vision problems in babies caused by brain injury, not eye damage. Researchers will study 600 children to identify different types of cerebral vision impairment (CVI) and how it affects development. The goal is to catch CVI e…

This study looks at 50 children with a rare heart condition who had the Fontan operation. Researchers use ultrasound to measure liver stiffness before and after surgery. The goal is to see if liver stiffness can predict future liver disease or other complications. This is an obse…

This study uses advanced MRI scans to see how well the pancreas is working in people with pancreatitis. Researchers will compare MRI results with other tests to find early signs of diabetes or digestive issues. About 195 children and young adults will take part, helping doctors p…

This study looks at how cholestatic liver disease affects red blood cells in children over age one. Researchers will measure red blood cell fragility and flexibility in 40 children with liver disease and compare them to healthy children. The goal is to understand the connection b…

This study follows 420 children in the pediatric ICU who are at risk for acute kidney injury. Researchers use a biomarker test (NGAL) and other assessments to predict which children will develop fluid overload and need dialysis. The goal is to improve timing of treatments and avo…

This study creates a registry for people with TFE renal cell carcinoma, a rare kidney cancer. Researchers will collect medical information, tumor samples, and images from up to 28 participants. The goal is to better understand the disease and help develop new treatments in the fu…

This study aims to understand how cystic fibrosis (CF) damages small blood vessels in the lungs. Researchers will use imaging to measure blood vessel changes in 86 people with CF, ages 5 to 21, and compare them to lung function. The goal is to learn more about the disease, not to…

This study looks at how single doses of baclofen, roflumilast, and memantine affect brain activity and behavior in 45 adults with Fragile X Syndrome. Participants take each drug or a placebo on separate days, and researchers measure changes in brain waves and clinical symptoms. T…

This study uses a new, contrast-free MRI technique to measure blood flow in the lungs of 26 children with cystic fibrosis (ages 6-21). Researchers want to see if blood vessel damage happens before or alongside the more commonly measured airway damage. The goal is to better unders…

This study tests whether a special communication technology can help deaf or hard-of-hearing children improve their language skills. About 114 children aged 3 to 10 with moderate to profound hearing loss and language delays will be randomly assigned to use the technology or conti…

This study aims to make a special type of MRI (using xenon gas) better at detecting changes in lung disease called interstitial lung disease. Researchers will test the method in 78 adults across multiple hospitals to ensure it is reliable and can be used widely. The goal is to he…