Centre Hospitalier Universitaire De Nice

This study looks at whether a drug called efgartigimod can help elderly patients (65 and older) with generalized myasthenia gravis lower their steroid doses. Steroids often cause serious side effects in older adults. The study will track 50 patients for 12 months to see if efgart…

This study looks at whether people with psoriasis who are doing very well on the drug guselkumab (Tremfya) can safely wait longer between injections. Researchers will follow 100 adults whose doctors have already extended their dosing intervals beyond the standard 9 weeks. The goa…

This study tests whether an artificial intelligence program can help doctors give the right dose of the drug rituximab to people with a kidney disease called membranous nephropathy. The disease causes the immune system to attack the kidneys, and rituximab helps calm that attack. …

This study tests whether the drug bimekizumab, given early after a psoriasis diagnosis, can prevent the disease from becoming a long-term condition. Forty adults with mild plaque psoriasis for less than 6 months or more than 2 years will receive either bimekizumab injections or a…

This study tests whether a new drug called CPX-351 works better than standard chemotherapy for adults aged 50 and older with a newly diagnosed, aggressive form of acute myeloid leukemia (AML). About 248 participants will be randomly assigned to receive either CPX-351 or standard …

This study tests whether adding narrowband UVB light therapy to the daily pill ritlecitinib works better than the pill alone for treating vitiligo. About 56 adults with non-segmental vitiligo covering 4-60% of their body will take part. The main goal is to see how much facial and…

This study looks at whether giving the drug ravulizumab early, after standard treatments, can help people with a severe myasthenia gravis crisis recover faster in the intensive care unit. About 30 adults in France will be observed for 6 months. The goal is to see if it reduces ti…

This study is developing a computer algorithm that can detect early Alzheimer's disease by analyzing a person's voice and speech patterns. Researchers will compare speech recordings from 100 adults aged 50 and older with existing brain and spinal fluid tests. If successful, this …

This study looks at whether getting a flu vaccine in the morning or evening helps people with chronic kidney disease build better protection. Researchers will compare antibody levels and flu infections between the two groups. The goal is to find the best vaccination timing for th…

This study is testing whether the drug omaveloxolone can improve swallowing difficulties in people with Friedreich's ataxia, a rare nerve disease that affects movement and coordination. About 40 French patients who have been taking the drug for at least six months will fill out a…

This study tests a new way to perform psoas tenotomy, a surgery that cuts a tendon to relieve hip pain after hip replacement. Instead of using a camera or X-ray, the surgeon uses ultrasound to guide the cut, which may be simpler and less invasive. The study will enroll 15 adults …

This study compares taking oral isotretinoin (a strong acne medicine) right away versus the usual antibiotics for moderate acne in people with darker skin (Fitzpatrick types IV-VI). The goal is to see if isotretinoin reduces acne-related dark spots better after 6 months. About 42…

This study tests whether taking L-tyrosine, a natural amino acid, can help lower stress in adults undergoing outpatient hernia surgery. About 150 participants will receive the supplement or a placebo before their operation. The goal is to see if it reduces anxiety without affecti…

This study looks at adults with advanced myelodysplastic syndromes (MDS) or acute myeloid leukemia (AML) who are receiving palliative care. Instead of giving blood transfusions based only on a fixed hemoglobin level, researchers will use a quality-of-life questionnaire to decide …

This study looks at whether a common surgery for pelvic organ prolapse can be safely performed without an overnight hospital stay. About 80 women with symptomatic prolapse will receive laparoscopic sacrocolpopexy (with or without robotic help) and be monitored to see if they can …

This study tests whether using a virtual reality headset during a scheduled cesarean section can help reduce pain and anxiety. Twenty women will use VR from admission through recovery. Researchers will measure how many accept the headset and track their pain and anxiety levels.

This study looks at how severe liver disease (cirrhosis) and liver transplant affect hardening of the arteries. Researchers will follow 95 adults who need a liver transplant. They want to see if the transplant can slow or reverse artery hardening and restore a key blood substance…

This study looks at how different types of hormone therapy (like birth control pills) affect knee looseness in healthy women aged 18 to 40. Researchers will measure knee movement using a special device to see if certain hormones make the knee more stable. The goal is to better un…

This study looks at why some older adults improve their muscle strength with exercise while others don't. Researchers will track 900 people aged 60 and older, measuring muscle power and blood markers before and after different physical activity programs. The goal is to learn how …

This study looks at sleep quality in people who had cancer between ages 15 and 24. Researchers will ask 400 survivors to fill out a detailed online questionnaire about their sleep, pain, and daily life. The goal is to find out how many have moderate to severe insomnia and what fa…

This study uses high-resolution ultrasound to look at nerves in people with Friedreich ataxia, a rare genetic disease that damages the nervous system and heart. Researchers want to see if nerve size and blood flow can help track how the disease progresses. The study involves 14 a…

This study looks at how melanoma tumors change their metabolism to resist immunotherapy drugs like anti-PD1. Researchers will compare tumor samples from 20 patients whose cancer responds to treatment versus those whose cancer does not. The goal is to find new ways to target cance…

This study tests a new way to measure blood flow in the tiny blood vessels of the brain right after a stroke is treated. Even when doctors successfully remove a clot, many patients still have disabilities—possibly because the smallest vessels aren't getting enough blood. Research…

This study looks at a common thinking trap called the 'tunnel effect,' where dentists focus so much on one detail that they miss the bigger picture, which can lead to mistakes. Researchers will survey 160 French dental professionals—from students to experienced surgeons—to find o…

This study looks at how many adults with type 2 diabetes experience severe emotional distress related to their condition. Researchers at a French hospital will ask 246 participants to fill out questionnaires about their feelings, quality of life, and diet. The goal is to understa…

This study tests whether a personalized exercise program can help older adults (70+) with cancer get stronger before surgery. Researchers will measure walking distance and quality of life to see if customizing the workout load improves results. The goal is to find better ways to …

This study looks at how GLP-1 medications change fat tissue in 40 people with obesity who are about to have weight-loss surgery. Researchers want to see if these drugs raise oxytocin levels in fat and how they affect fat scarring. The goal is to better understand how GLP-1s work …

This study talks to 10 migrants and socially vulnerable people who visit the Doctors of the World center in Nice. Researchers want to learn about their health needs and whether they would join group health programs. The goal is to find ways to overcome barriers and make health pr…

This study looks at whether the heart's pumping ability affects how well ICU patients can breathe on their own after a breathing tube. It involves 250 adults who have been on a ventilator for more than 48 hours and are ready for a breathing test. Researchers will use ultrasound t…

This study is checking if people with lymphedema (a condition causing arm or leg swelling) have higher levels of a blood fat called lipoprotein(a), which is linked to heart attacks and strokes. Researchers will test 100 adults with lymphedema to see how common high LP(a) is and h…

This study is testing whether a quick, painless finger-prick test measuring lactate levels can help predict which accident victims with serious injuries will have poor outcomes. Researchers will enroll 550 adults involved in road accidents or falls over 2 meters. The goal is to g…

This study looks at a rare but dangerous infection caused by Bacillus cereus bacteria in premature newborns. Researchers will analyze the bacteria's DNA and review medical records from 40 babies to identify which genetic features are linked to higher death risk. The goal is to be…