Ain Shams University

This study tests whether adding venlafaxine, a drug typically used for depression, can improve outcomes for people with rheumatoid arthritis who still have moderate to high disease activity despite standard treatments. Researchers will enroll 70 adults and measure changes in join…

This study tests whether using a special breathing machine mode (APRV) right after heart surgery can improve lung function and oxygen levels in very obese patients. About 180 adults with severe obesity scheduled for elective heart surgery will be randomly assigned to receive eith…

This study tests whether giving tranexamic acid (TXA) during weight-loss surgery can reduce blood loss in people with a very high body mass index (BMI over 45). About 128 high-risk patients will receive TXA, and doctors will measure bleeding during and after surgery, as well as c…

This study tests whether a dietary supplement called tributyrin can help people with type 2 diabetes improve blood sugar control, reduce inflammation, and lower heart disease risk. About 60 adults with diabetes and a high risk of heart problems will receive either tributyrin plus…

This study tests whether adding erythropoietin gel to a standard bone graft helps preserve bone and gum tissue around new dental implants. About 26 adults needing a front tooth implant will be randomly assigned to receive either the gel mixture or graft alone. Researchers will me…

This study tests whether adding N-acetylcysteine (NAC) to standard care helps newborns with sepsis recover faster. Sepsis causes dangerous inflammation and cell damage, partly due to oxidative stress. NAC may reduce that damage. The trial will enroll 50 near-term and full-term in…

This study tests whether a low or high dose of alpha-lipoic acid (an antioxidant) can help people hospitalized with a COPD flare-up. Researchers will measure inflammation, oxygen levels, and recovery time. 75 adults will receive either a placebo, 600 mg, or 1200 mg of alpha-lipoi…

This study tests whether adding rutin (a plant compound) to vitamin C can lower inflammation and fat buildup in the liver better than vitamin C alone. It involves 120 adults with metabolic fatty liver disease (MASLD) and will measure changes in blood markers of inflammation and s…

This study tests whether taking vitamin C and coenzyme Q10 can prevent kidney damage in cancer patients receiving cisplatin chemotherapy. About 75 adults starting chemotherapy will receive these antioxidants alongside their treatment. The goal is to see if these supplements reduc…

This study tests whether giving a sedative called dexmedetomidine during and after mitral valve surgery can prevent a common heart rhythm problem called atrial fibrillation. About 140 adults having this surgery will be randomly assigned to receive the drug or a placebo. The goal …

This study looks at two methods to control pain after tonsil removal in children aged 5-10 who have mild to moderate sleep apnea. One method uses fentanyl (an opioid), the other uses a combination of non-opioid pain medicines. The goal is to see if the opioid-free approach works …

This study tests two different medicines placed inside infected teeth to see which one kills more bacteria and causes less pain afterward. About 52 adults with a single infected tooth will take part. The goal is to find a better way to ease discomfort and improve treatment succes…

This study looks at whether avoiding opioid painkillers during heart bypass surgery helps elderly patients recover faster. Researchers will compare opioid-free anesthesia to standard opioid-based anesthesia in 60 patients aged 65 and older. The goal is to see if it reduces time o…

This study tests if using a cold anti-inflammatory liquid (ketorolac) inside the tooth after root canal can lower pain better than the same liquid at room temperature. Sixty adults with infected teeth will be treated and asked to rate their pain. The goal is to find a simple way …

This study will test two different medicines added to a standard numbing injection for a nerve block in 60 people with myasthenia gravis undergoing chest surgery to remove the thymus gland. The goal is to see which additive—dexmedetomidine or dexamethasone—provides longer pain re…

This study compares three different drug combinations used to sedate people during an upper GI endoscopy (a camera down the throat). The goal is to see which combination helps patients wake up fastest and provides the best sedation. 75 adults aged 18-65 who need this procedure wi…

This study tests whether melatonin, a natural sleep hormone, works as well as midazolam (a common sedative) to reduce anxiety and confusion in children before tonsillectomy. About 195 children will receive one of the two medicines before surgery. The goal is to find a safer optio…

This study looks at whether lactoferrin, a protein found in milk, can improve pain control after a planned C-section. Ninety women will receive either lactoferrin or a placebo before and after surgery, along with standard pain medicine. The goal is to see if it lowers pain levels…

This study compares two suction-assisted techniques for removing medium-sized kidney stones (2-3 cm) in adults aged 18-60. The goal is to see which method better clears stones and reduces infection after surgery. Participants will be randomly assigned to one of the two techniques…

This study tests whether a resilience training program can help parents of young children with Down syndrome feel more accepting and less burdened. About 50 parents will be randomly assigned to either the training or usual care. Researchers will measure changes in acceptance, rej…

This study compares three different surgical methods for treating an enlarged prostate (over 80 grams) that causes urinary problems. The goal is to see which technique is safest and allows men to have their urinary catheter removed the soonest. About 105 men will be randomly assi…

This study looks at how two different types of anesthesia affect inflammation after inguinal hernia repair. Forty adults having elective surgery will be randomly assigned to receive either total intravenous anesthesia (TIVA) or inhaled sevoflurane. Researchers will measure inflam…

This study will check if measuring the difference between arterial and venous CO2 levels, along with lactate and oxygen saturation, can help predict serious problems after heart bypass surgery. Researchers will follow 130 adults for 7 days after surgery to see if these measuremen…

This study compares two dental treatments—functional crown lengthening and deep margin elevation—for fixing deep cavities in back teeth. Researchers will measure gum health and a chemical marker (TNF-α) in 20 adults aged 20-50 with healthy gums. The goal is to see which method be…

This observational study looks at how cerebral small vessel disease (SVD) — a common age-related brain condition — affects walking and balance. Researchers will use brain scans (MRI and EEG) to compare brain activity in 40 older adults with SVD and healthy volunteers. The goal is…