Ain Shams University

This study compares two ways to treat a severely damaged upper molar: root amputation (removing only the bad root and keeping the rest of the tooth) versus pulling the tooth and placing a dental implant. Over 12 months, researchers will track pain, bone healing, and implant stabi…

This study compares two different antibiotic combinations to see which works better at wiping out multi-drug resistant bacteria in adults. Sixty hospitalized patients will receive either meropenem plus colistin or imipenem/cilastatin plus tigecycline. Researchers will track lab r…

This Phase 4 trial tests whether adding nicotinamide (vitamin B3) to standard sepsis care can reduce organ failure and inflammation in ICU patients. Researchers will give 60 adults with sepsis either nicotinamide or a placebo for 7 days, measuring changes in organ function and bl…

This study compares two treatments for stress urinary incontinence (leaking urine when you cough, sneeze, or exercise). One group gets a shot of platelet-rich plasma (PRP) made from their own blood, while the other gets a standard surgical sling. The trial will enroll 42 women an…

This study tests whether the antioxidant alpha-lipoic acid can help people recover from sudden worsening of COPD (called exacerbations). 75 adults will receive either a low dose (600 mg), a high dose (1200 mg), or a placebo pill for 10 days, alongside standard hospital care. Rese…

This study tests whether tributyrin, a dietary supplement that turns into butyrate in the body, can improve blood sugar control, reduce inflammation, and lower heart disease risk in people with type 2 diabetes. Sixty participants at high risk for heart problems will receive eithe…

This phase 2 trial tests whether taking rutin and vitamin C together can reduce inflammation and oxidative stress in people with fatty liver disease (MASLD). 120 participants will take either the combination or vitamin C alone for 12 weeks, alongside diet and exercise advice. The…

This study tests whether taking a daily probiotic capsule for 12 weeks can reduce the chance of atrial fibrillation (AF) returning in people who have just had a cardioversion (a procedure to restore normal heart rhythm). Fifty-six adults aged 40 and older with persistent AF will …

This study compares two dental procedures—functional crown lengthening and deep margin elevation—for treating cavities on the sides of back teeth that extend close to the bone. Twenty adults aged 20-50 with healthy gums will be randomly assigned to one procedure. Researchers will…

This study tests whether adding erythropoietin gel to a standard bone graft helps preserve bone and gum tissue around dental implants placed right after a tooth is pulled. About 26 adults aged 20–50 with a non-restorable front tooth will receive either the gel-plus-graft or graft…

This study compares two suction-assisted techniques used during kidney stone surgery: Direct In-Scope Suction (DISS) and Flexible and Navigable Suction Ureteric Access Sheath (FANS). The goal is to see which method better clears stones and reduces infections after surgery. About …

This study tests whether adding a liquid called Theravex to a bone graft helps improve bone growth and implant stability during sinus lifts. Sixteen adults with low bone height in the upper jaw will receive either the graft alone or a graft mixed with Theravex. Researchers will m…

This study tests whether adding N-acetylcysteine (NAC) to standard care helps newborns with sepsis. Sepsis causes dangerous inflammation and cell damage. NAC may reduce this damage by boosting the body's defenses. The trial will enroll 50 near-term and term infants to see if NAC …

This study tests whether adding alpha lipoic acid (a strong antioxidant) to standard chemotherapy helps people with advanced non-small cell lung cancer. About 60 adults with stage III or IV lung cancer will take 600 mg of alpha lipoic acid daily alongside their chemo. Researchers…

This study tests whether giving tranexamic acid (TXA) through a vein during weight-loss surgery can reduce blood loss in patients with a very high body mass index (BMI over 45). About 128 high-risk adults will receive TXA or a placebo to see if it lowers the need for blood transf…

This study tests whether a supplement called palmitoylethanolamide (PEA) can help people with mild-to-moderate ulcerative colitis. Researchers will measure changes in disease activity, quality of life, and inflammation markers in 60 participants. The goal is to see if adding PEA …

This study tests whether adding venlafaxine, a common antidepressant, to standard rheumatoid arthritis (RA) treatment can better control disease activity. About 70 adults with moderate to severe RA who are already on stable medication will receive either venlafaxine or a placebo …

This study tests whether taking vitamin C and coenzyme Q10 can prevent kidney damage in cancer patients receiving cisplatin chemotherapy. About 75 adults with various cancers who have not had chemo before will take these supplements alongside their treatment. The goal is to see i…

This study tests whether using a special ventilator mode called APRV before removing the breathing tube can improve lung function in severely obese patients after elective heart surgery. About 180 adults with a BMI of 40 or higher will be randomly assigned to receive either APRV …

This study compares two treatments for severely damaged lower molars: a tooth-saving surgery called hemisection (removing the damaged root) versus replacing the whole tooth with a dental implant. Researchers will track 28 participants over 12 months to see which option leads to b…

This study tests whether adding melatonin, a natural hormone, to the strong antibiotic colistin helps adults with hard-to-treat bacterial infections. These infections are resistant to many drugs and can be life-threatening. The study will compare patients who get melatonin versus…

This study will see if artificial intelligence can accurately identify and assess the risk of oral lesions that might turn into cancer. Researchers will take photos and cell samples from 120 people with suspicious mouth sores, then train an AI model to compare its findings with e…

This study looks at 115 children aged 6 months to 5 years who have a hole in the heart (VSD) and need surgery. Doctors want to see if an ultrasound probe placed in the food pipe (TEE) can measure heart pressure as accurately as the standard method using a thin tube (catheter) ins…

This study tests whether the sedative drug dexmedetomidine can prevent new-onset atrial fibrillation (a fast, irregular heartbeat) in the days after mitral valve surgery. Researchers will randomly give 140 adults either the drug or a placebo during and after surgery. The goal is …

This study tests whether the supplement glutamine can prevent nerve damage caused by the chemotherapy drug vincristine in children and teens with cancer. About 70 participants, aged 6 to 18, will take glutamine twice daily for 14 days during their treatment. Researchers will trac…

This study tests whether lactoferrin, a natural protein found in milk, can help manage pain after a cesarean section. Ninety women having planned C-sections will receive either lactoferrin or a placebo before and after surgery, alongside standard painkillers. The goal is to see i…

This study tests whether adding dexamethasone to the standard painkiller bupivacaine improves pain relief for newborns undergoing inguinal hernia repair. 150 full-term infants will be randomly assigned to receive either the combination or bupivacaine alone via a caudal injection.…

This study compares opioid-free anesthesia using dexmedetomidine and ketamine to standard opioid-based anesthesia in 60 elderly patients undergoing elective coronary artery bypass surgery. The goal is to see if avoiding opioids leads to faster recovery, less confusion, and fewer …

This trial will test whether giving a single dose of gabapentin before weight-loss surgery can reduce pain and the need for painkillers in the first 24 hours after the operation. About 102 people with severe obesity scheduled for bariatric surgery will receive either gabapentin o…

This study compares two common drugs, silodosin and tamsulosin, to see which one better relieves moderate to severe urinary symptoms caused by an enlarged prostate. About 140 men aged 50 and older will take each medication for four weeks in a crossover design, with no washout per…

This study looks at whether a combination of non-opioid pain medicines works as well as fentanyl for children aged 5-10 with mild to moderate sleep apnea who are having their tonsils removed. The goal is to control pain with fewer breathing problems and side effects. About 64 chi…

This study tests whether two common antioxidants, N-Acetylcysteine (NAC) and Alpha-Lipoic Acid (ALA), can improve pain control and reduce the need for strong painkillers after laparoscopic appendix removal. 180 adults aged 18-65 undergoing this surgery will receive either NAC, AL…

This study tests whether melatonin, a natural sleep hormone, works as well as midazolam (a common sedative) to reduce anxiety and confusion in 195 children before and after tonsillectomy. Melatonin may offer a safer option with fewer side effects. The goal is to find a better way…

This study looks at whether adding a nerve block to the back of the hip to two standard front-hip blocks can improve pain relief after hip surgery. About 50 adults having hip surgery will be split into two groups to compare pain scores and the need for extra pain medicine in the …

This study compares two different medicines placed inside a tooth during a root canal to see which one is better at killing bacteria and reducing pain afterward. About 52 adults with infected single-root teeth will take part. The goal is to find which treatment leads to less disc…

This study looks at 60 myasthenia patients having chest surgery to remove the thymus gland. They will get a nerve block with bupivacaine plus either dexmedetomidine or dexamethasone to see which provides longer pain relief. The goal is to reduce the need for extra pain medication…

This study compares three different surgical techniques for men with enlarged prostates (over 80 grams) who have trouble urinating. The goal is to see which method is safest and works best in the short term. About 105 men will take part and be followed for at least one year after…

This study tests whether a resilience training program can help parents of young children with Down syndrome feel more accepting and less burdened. About 50 parents will be randomly assigned to either the training or usual care. Researchers will measure changes in acceptance, rej…

This study compares two types of nerve blocks (ESPB and paravertebral) to see which provides better pain relief after a total abdominal hysterectomy. The goal is to reduce the need for morphine and improve comfort. 48 women aged 30-60 will participate.

This study tests whether a cold anti-inflammatory rinse (ketorolac tromethamine at 2-5°C) placed inside the tooth after root canal can lower post-treatment pain compared to the same rinse at room temperature. Sixty adults with painful tooth infections will rate their pain and hav…

This study looks at how cerebral small vessel disease—a common brain condition in older adults—affects walking and balance. Researchers will use brain imaging and EEG to compare brain activity in 40 people with the disease and healthy controls. The goal is to understand which bra…

This study aims to see how accurate three different face-scanning techniques are compared to traditional dental molds. Sixty volunteers will have their faces scanned using a stationary scanner, a handheld scanner, and a mobile phone app. The results will help doctors choose the b…

This study looks at whether the LASMAR score, which is based on a camera look inside the uterus, can predict how well surgery to remove fibroids will go. Researchers will follow 88 women having this surgery to see if the score relates to surgery time, complications, and the need …

This study looks at how frailty impacts the quality of life in women aged 60 and older who are newly diagnosed with breast cancer. Researchers will measure changes in well-being and frailty over six months. The goal is to help doctors make better treatment decisions that focus on…

This study looks at whether certain blood markers can predict delirium (sudden confusion) in older adults with heart failure. Researchers will compare two markers: one for inflammation (SII) and one for blood sugar and fat levels (TyG). They aim to find a simple way to identify h…

This study will check if measuring CO2 gap, lactate, and oxygen in the blood can help predict serious problems after heart bypass surgery. About 130 adults having planned bypass surgery will be followed for 7 days after their operation. The goal is to see if these simple tests ca…

This study looks at whether a weak bladder muscle affects how well prostate surgery works for men with trouble urinating. About 90 men who need a catheter will be split into two groups based on bladder strength. The goal is to see if they can urinate on their own after surgery.

This study looks at how muscle loss (sarcopenia) is related to tiredness and dizziness when standing up in people aged 65 and older. Researchers will compare 90 older adults with and without sarcopenia to see if those with muscle loss feel more tired and have more dizziness. The …