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Brain scans reveal why walking gets harder with Age-Related vessel disease

NCT ID NCT07372937

Knowledge-focused Sponsor: Ain Shams University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how cerebral small vessel disease—a common brain condition in older adults—affects walking and balance. Researchers will use brain imaging and EEG to compare brain activity in 40 people with the disease and healthy controls. The goal is to understand which brain changes cause gait problems, which could lead to better therapies in the future.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could point toward better rehabilitation methods for walking problems in people with small vessel disease.
What could go wrong
This is a small, early observational study with no treatment being tested. It may not lead to direct benefits for participants or immediate clinical changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Mar 2026

An estimate. Start dates often move.

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adults aged 50 years or older attending the Neurology outpatient clinics at Ain Shams University Hospitals, including patients with small vessel disease and gait impairment, and healthy controls.

Ages

50 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 50 years or older. * Clinical and radiological diagnosis of cerebral small vessel disease (SVD), confirmed by MRI findings such as white matter hyperintensities, lacunes, or microbleeds. * Fazekas score 2 or 3 on MRI. * Presence of slowly progressive gait disturbance (e.g., slowness, imbalance, freezing) rather than acute stroke presentation. * Ability to give informed consent and cooperate with testing procedures. Exclusion Criteria: * Presence of other neurodegenerative disorders (e.g., Parkinson's disease, Alzheimer's disease). * History of large vessel stroke or intracerebral hemorrhage. * Contraindications to MRI (e.g., pacemaker, metallic implants, severe claustrophobia). * Severe cognitive impairment that prevents participation (MoCA \<10). * Musculoskeletal or orthopedic causes of gait disturbance not related to neurological dysfunction.

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Conditions

The condition(s) this trial relates to.

Cerebral Small Vessel Diseases Mobility Limitation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cerebral small vessel disease

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Ain Shams University Hospitals

    Cairo, Cairo Governorate, 11566, Egypt

More trials for these conditions

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