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New pain cocktail could ease recovery after chest surgery

NCT ID NCT07424599

Symptom relief Sponsor: Ain Shams University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether adding dexmedetomidine or dexamethasone to a standard numbing drug (bupivacaine) can provide longer pain relief after thoracoscopic thymectomy in people with myasthenia gravis. Sixty patients will be randomly assigned to one of three groups. The main goal is to see how long it takes before they need extra pain medication.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
bupivacaine with either dexmedetomidine or dexamethasone
What this could lead to
If it works, this could point toward a better way to manage pain after thymectomy, reducing the need for additional painkillers.
What could go wrong
This is a small, early-phase study with only 60 participants, so results may not apply to all patients. There is also a risk of side effects from the added medications.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Mar 2026

An estimate. Start dates often move.

Expected to finish

Sep 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * myasthenic patients * American Society of Anesthesiologists (ASA) physical grade of 2-3) * who underwent video assisted thoracoscopic thymectomy Exclusion Criteria: * Refused participation in the study, * known allergy for this study drugs , * Contraindication to the ESPB as infection at block site \& marked chest cage deformity, * significant bleeding disorders , * patients with significant renal or liver dysfunction, * heart block , * poor ventilatory function, * severe chronic obstructive pulmonary disease, * morbid obesity, * mental disability, or communication difficulties that hindered effective pain assessment, * Individuals who was converted to open thoracotomy or those re-explorated for surgical related issues.

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Conditions

The condition(s) this trial relates to.

myasthenia gravis Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Postoperative pain, acute

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

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