Could a common vitamin help fight sepsis? new trial aims to find out
NCT ID NCT07655791
First seen Jun 22, 2026 · Last updated Jun 23, 2026 · Updated 1 time
Summary
This Phase 4 trial tests whether adding nicotinamide (vitamin B3) to standard sepsis care can reduce organ failure and inflammation in ICU patients. Researchers will give 60 adults with sepsis either nicotinamide or a placebo for 7 days, measuring changes in organ function and blood markers. The goal is to see if this safe, inexpensive vitamin can improve outcomes in a life-threatening condition.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
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Locations
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El Demardash Hospital
Cairo, Egypt
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Nicotinamide (vitamin B3) 1000 mg oral tablet
What this could lead to
If it works, this could point toward a simple, safe, and cheap vitamin supplement to help control sepsis and reduce organ failure in the ICU.
What could go wrong
This is a small, early-stage trial with only 60 patients, so results may not apply broadly. Nicotinamide at high doses can cause side effects like diarrhea or stomach upset.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.